Abstract: An extrusion process for creating a roof ditch molding including forming a main body from a plastic material in a first stage extrusion, conveying the main body through a stacked array of die plates and into a first stage cooling tank, and communicating the main body from an outlet of the first stage cooling tank to a second stage extruder with crosshead die for applying a skim film bonding layer to the main body. Additional steps include applying a decorative layer over the skim bonding layer, communicating the main body to a third stage extruder with cross head die for applying wing portions in partially overlapping fashion along opposite side edges of the decorative layer and drawing the completed ditch molding through a second stage cooling tank prior to conducting one or more finishing operations.

Abstract: A tampon including a pledget, a wicking member disposed in direct contact with the pledget, and a withdrawal cord is disclosed. The wicking member is non-coaxially arranged with respect to the withdrawal cord.

Abstract: This disclosure provides methods of treating cancer comprising administering effector cell engaging molecules comprising one or more tumor targeting moieties and one or more effector cell engaging moieties. For example, the effector cell engaging molecules can have a greater cumulative potency for the tumor targeting moieties than the effector cell engaging moieties, the tumor targeting moieties can have greater avidity than the effector cell engaging moieties, and/or can be multimeric. The methods comprise, for example, administering different doses of effector cell engaging molecules based on the subject's symptoms and/or administering chimeric antigen receptor expressing cells.

Abstract: A method for determining a presence of arthritis in a patient, including obtaining a first image of a patient's joint, wherein the first image is a visible light image, obtaining a second image of the patient's joint, wherein the second image is a thermal light image, determining an outline of the patient's joint from the first image, determining an outline of a reference area from the first image, wherein the patient's joint is adjacent to the reference area, determining a first representative topological temperature within the outline of the patient's joint of the first image from the second image, determining a second representative topological temperature within the outline of the reference area of the first image from the second image, comparing the first representative topological temperature and the second representative topological temperature; and determining a likelihood of the presence of arthritis within the patient's joint.

Abstract: The present disclosure relates to apparatuses and methods for making tampons including primary and secondary absorbent members. During assembly, primary absorbent members, a continuous length of secondary absorbent members, and a continuous cord are advanced in a machine direction. Leading edges of the primary absorbent members are separated from each other in the machine direction by a pitch distance. Discrete secondary absorbent members are cut from the continuous length of secondary absorbent members. Leading edges of the discrete secondary absorbent members are also separated from each other in the machine direction by the pitch distance. The continuous cord is positioned on the secondary absorbent members. And a secondary absorbent member is positioned in contact with a primary absorbent member. A thread is combined with the continuous cord, the secondary absorbent member, and the primary absorbent member.

Abstract: The present invention relates to novel cGAS inhibitor compounds, to pharmaceutical compositions comprising the compounds, and to methods of using the compounds and compositions to treat certain pathological conditions.

Abstract: A suspender attachment device interconnected to an end of a suspender strap and operative to securely yet releasably attach the suspender strap to a belt loop on a pair of pants. The device includes a suspender interconnect portion having an interconnect channel dimensioned to receive the end of the suspender strap therethrough and to retain the end of the suspender strap therein. The device also includes a belt loop attachment portion having an attachment channel dimensioned and configured to receive and releasably retain the belt loop therein, the belt loop attachment portion is connected to the suspender interconnect portion. A guide portion having a guide channel is disposed in communication with the attachment channel, the guide channel dimensioned and configured to facilitate disposition of the belt loop into and out of the attachment channel by a user.

Abstract: The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.

Abstract: A method of manufacturing a catalyst article, the method comprising: providing a slurry comprising a support material, palladium ions, alkaline-earth-metal ions and an organic compound, wherein the organic compound comprises a functional group selected from a sulfo group (—SO3H), a sulfonyl group (—S(?O)2—) and a sulfinyl group (—S(?O)—); disposing the slurry on a substrate; and heating the slurry to form nanoparticles of the palladium and nanoparticles of a sulfate of the alkaline earth metal on the support material.

Abstract: The present disclosure relates to apparatuses and methods for making tampons including primary and secondary absorbent members. During assembly, primary absorbent members, a continuous length of secondary absorbent members, and a continuous cord are advanced in a machine direction. Leading edges of the primary absorbent members are separated from each other in the machine direction by a pitch distance. Discrete secondary absorbent members are cut from the continuous length of secondary absorbent members. Leading edges of the discrete secondary absorbent members are also separated from each other in the machine direction by the pitch distance. The continuous cord is positioned on a first surface of the secondary absorbent members. And a second surface of a secondary absorbent member is positioned in contact with and in a facing relationship with a primary absorbent member. A thread is sewn through the continuous cord, the secondary absorbent member, and the primary absorbent member.

Abstract: The present invention provides compounds of the formula: where R1, R2, R3, R4, R5, A, B, and Y are as described herein, pharmaceutically acceptable salts thereof, and methods of using these compounds and salts for treating patients for cancer.

Abstract: Provided herein are antibodies with conditional affinity for an antigen. The affinity of an antibody with conditional affinity for an antigen may be altered by a small molecule agent. Antibodies with conditional affinity may be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.

Abstract: A method of manufacturing a catalyst article, the method comprising: providing a slurry comprising a support material, palladium ions, alkaline-earth-metal ions and an organic compound, wherein the organic compound comprises a functional group selected from a sulfo group (—SO3H), a sulfonyl group (—S(?O)2—) and a sulfinyl group (—S(?O)—); disposing the slurry on a substrate; and heating the slurry to form nanoparticles of the palladium and nanoparticles of a sulfate of the alkaline earth metal on the support material.

Abstract: A process and related assembly for creating an extrusion molded article with a chemically applied outer film. An extruded base material is formed during a first extrusion operation, following which a multi-layer film is bonded to the base material while the base material still at an above ambient temperature. The multi-layer film further includes successive layers of each of a polypropylene (PP), an adhesive, a polyethylene terephthalate (PET), a coating and s subsequent surface PET. The step of bonding of the film further occurs during an intermediate step between the first extrusion operation for forming the base material according to a given profile section and a subsequent extrusion operation for applying additional material along an edge of the film, the additional material including profile wings as required for a given design.

Abstract: A prosthetic device includes a flexible interface configured to conform to a residual limb of a user, a prosthetic socket including an outer shell more rigid than the flexible interface and positioned external to at least a portion of the flexible interface, and one or more vibrational devices placed in connection with the flexible interface to impart vibration to the residual limb.

Abstract: The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to GDF15, as well as methods and uses for the antibodies.

Abstract: Disclosed herein is an electrolyte comprising OH? and a hydrogen evolution electrocatalyst, an oxygen evolution electrocatalyst, a bifunctional hydrogen/oxygen evolution electrocatalyst, or any combination thereof for use in in situ deposition or utilization.