Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: A method comprises exposing the surface of an optical microcavity characterized by at least one resonance frequency to a sample such that a single particle or molecule from the sample adsorbs onto the surface of the microcavity; evanescently coupling a probe laser beam into the microcavity, the wavelength of the probe laser beam substantially matching the at least one resonance frequency; illuminating the surface of the microcavity with a free space pump light beam and moving the focal spot of the free space pump light beam such that the focal spot substantially overlaps with the single particle/molecule; and detecting light from the probe laser beam. The wavelength of the free space pump light beam generates sufficient heat via energy absorbed by the single particle/molecule to induce a shift in the at least one resonance frequency, thereby providing a change in an optical characteristic of the detected light.

Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: Mobile platforms and methods may provide for an integrated circuit such as a system on chip (SoC), a first heat spreader thermally coupled to the integrated circuit and a phase change material configuration thermally coupled to the first heat spreader. The integrated circuit may include logic to operate the integrated circuit in a performance burst mode according to a duty cycle, wherein the performance burst mode causes a phase change material to enter a liquid state within a graphite matrix of the phase change material configuration.

Abstract: An elongate hollow tube having two or more fidgets molded onto or attached to an outside surface of said tube is described. The tube can be slipped over a smooth elongated base object, such as a pencil or similar object, to provide manipulatives for students.

Abstract: An attachable trimmer includes a trimming unit, an arm assembly, a limit switch, and a rod assembly as the attachable trimmer is mounted onto a mower deck of a lawn mower. The trimming unit is connected with the arm assembly while the limit switch is oppositely positioned of the trimming unit across the arm assembly. The rod assembly is connected with the arm assembly in between the trimming unit and the limit switch. The rod assembly moves the attachable trimmer in between an expanded position and a retracted position upon the user's discretion. The trimming unit is only operational when the attachable trimmer is at the expanded position as the limit switch completes an electrical circuitry to electrically power the trimming unit.

Abstract: A bass drum beater assembly which is to strike a bass drum face by actuation of a foot pedal. The bass drum beater assembly is capable of being quickly turned one hundred and eighty degrees to cause the back side of the beater head to strike the bass drum face rather than the front side. The bass drum beater assembly is also quickly axially adjustable to vary the striking position on the bass drum face.

Abstract: Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject. Provided also are bacterial formulations for oral or gastric administration to a mammalian subject in an effective amount for prevention or treatment of a gastrointestinal disease, disorder or condition.

Abstract: The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Abstract: The present invention is related to a handheld tethered ball device comprising a tether assembly and a ball unit coupled therewith. The tether assembly includes a cord and a handle, which can be coupled to one another by means of a swivel. The cord preferably ends in a terminal loop that attaches to a ball retention cord protruding from the ball unit. An illumination assembly is included in the ball unit to provide various light emitting patterns. The illumination assembly is powered by batteries. Batteries are concealed by a securable battery cover, which is secured by at least one screw. The illumination assembly is attached to an aperture positioned between retention apertures on the ball unit, to which the ball retention cord is coupled.

Abstract: Methods and arrangements to redirect a forward thrust generated by a propeller of a watercraft to provide a non-forward thrust are disclosed. More specifically, embodiments comprise a control surface to redirect the forward thrust from the propeller. Based upon a position (i.e., distance and orientation) of the control surface with respect to the propeller, the redirection generates the non-forward thrust or thrusts. By redirecting a component of the forward thrust back toward the bow, the net forward or reverse, port or starboard thrusts and rotational thrust can be adjusted in fine increments. For instance, by adjusting the amount of prop wash hitting the control surface, the magnitude of the redirected thrust from the control surface can be adjusted. Further, adjusting the angle of the control surfaces adjusts the direction as well as magnitude of a reverse thrust component. The net thrust can be in any direction and rotational.

Abstract: A patient interface device (8) that includes a cushion (12) structured to receive a flow of treatment gas, a frame (14) having a central portion (17) structured to couple with the cushion and a strap (18a, 18b) extending from the central portion, a headgear component (28) including at least one of a top portion (30) adapted to fit on top of a patient's head and a rear portion (32) adapted to fit behind the patient's head, and a coupling mechanism (34a, 34b) structured to couple the strap to the headgear component, wherein an end portion of the strap is structured to pass through an opening in the coupling mechanism, fold back in a direction toward the central portion of the frame, and releaseably attach to the strap, such that pulling the end portion of the strap toward the central portion of the frame tightens the patient interface device.

Abstract: A nasal prong (26) for a cushion member adapted for use with a patient interface device that includes a casing (134,136), a flap (132) extending from the casing and being adapted to be inserted into a nostril of a patient, and a bottom cap (138). The casing and the bottom cap define a space. A fill material (140) is disposed in the space defined by the casing and the bottom cap, wherein the casing is structured to deform and conform to a shape of a portion of the nostril when the nostril applies pressure to the casing.

Abstract: Methods and apparatuses for resonance tuning of microcavities are provided. An apparatus comprises a whispering gallery mode optical microcavity characterized by at least one resonance frequency; optical components configured to evanescently couple a probe laser beam into the microcavity; an absorber element in thermal contact with the microcavity; and optical components configured to illuminate the absorber element with a free space pump light beam, wherein the absorber element is configured to absorb energy from the free space pump light beam, thereby generating heat, and to transfer the heat to the microcavity, thereby inducing a shift in the at least one resonance frequency. The absorber element may be configured as a pillar forming an interfacial region with the microcavity at one of the ends of the pillar. The surface of the microcavity may be substantially free of a coating material.

Abstract: Methods and apparatuses for single particle and single molecule spectroscopy are provided.

Abstract: A patient interface device for delivering a flow of breathing gas to an airway of a patient, comprises a mask component and auto-adjusting headgear. The auto-adjusting headgear comprises one or more straps wherein the materials have elasticity characteristics such that the headgear self-adjusts. The headgear comprises two lateral strap sections, a rear strap section, and a top strap section. The strap sections are of varying materials and thicknesses to control the properties of the strap sections. In one embodiment, at least a portion of a strap includes a high friction material disposed so as to contact a portion of the user responsive to the headgear being donned by a user.

Abstract: A patient interface device for delivering a flow of breathing gas to an airway of a patient, comprises two or more headgear straps, a cushion, and a thermoplastic hub positioned in the cushion for connection to an elbow or other fluid connector. The cushion is integrally connected to the headgear straps, and the integrated cushion and strap system is overmolded onto the hub.