Abstract: This invention relates to compounds of general Formula I in which A, R1, R2, R3 and R4 are as defined herein, and the pharmaceutically acceptable salts thereof; to pharmaceutical compositions comprising such compounds and salts; to methods of using such compounds, salts and compositions for treating pulmonary hypertension and related diseases, like pulmonary arterial hypertension; to methods of using such compounds, salts and compositions for treating abnormal cell growth, such as cancer; and to processes to make such compounds, salts and compositions.

Abstract: Systems, methods and computer-readable media are provided for receiving an indication to suspend a first event associated with a first resource indicator that is stored in a first data file associated with a first resource management software utilized by a first entity. A second indication to suspend the first event is determined to be provided by a second entity utilizing a second resource management software, the second indication to suspend the first event indicating a modification to both the first data file associated with a first resource management software and a second data file associated with the second resource management software. The first data file is reconciled by instructing the first resource management software to modify the first resource indicator in the first data file so as to correspond to a modification to a second resource indicator associated with the second data file.

Abstract: Techniques are provided for storage tier verification checks. A determination is made that a mount operation of an aggregate of a set of volumes stored within a multi-tier storage environment has completed. A first metafile and a second metafile are maintained to track information related to the storage of objects of a volume of the aggregate within a remote object store that is a tier of the multi-tier storage environment. A distributed verification is performed between the first metafile and the second metafile to identify an inconsistency. Accordingly, the first metafile and the second metafile are reconciled to address the inconsistency so that storage information within the first metafile and the second metafile are consistent.

Abstract: Systems and methods are provided for informing a user about the emotional response of the user to a presentation. Facial expressions of the user are monitored while the user is presented with the presentation. The facial expressions are analyzed to determine an emotion displayed at one or more specific times of the presentation. The user is provided with information about the emotion conveyed by the facial expressions of the user. The user is further provided with an opportunity to take a selected action that corresponds to the emotion conveyed.

Abstract: Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject. Provided also are bacterial formulations for oral or gastric administration to a mammalian subject in an effective amount for prevention or treatment of a gastrointestinal disease, disorder or condition.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: The disclosed techniques improve user engagement and promote efficient use of computing resources by providing dynamically controlled aspect ratios for communication session renderings based on a physical orientation of a device. In some configurations, a system can select a first aspect ratio for individual video streams of a communication session when a device is in a first orientation, e.g., a portrait orientation. In addition, the system can select a second aspect ratio for the individual video streams when the device is in a second orientation, e.g., a landscape orientation. In some configurations, the first aspect ratio can be greater than the second aspect ratio, or the aspect ratios can be selected based on a target aspect ratio, which can be adjusted over time. By dynamically selecting an aspect ratio for individual stream renderings, screen space of a device can be optimized while the device is held in various physical orientations.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: A heating, ventilation and air conditioning system (200) reduces energy consumption in a building (202) by turning on and off all compressors (212, 214, 216). The HVAC system (200) includes a plurality of in-flow air temperature sensors (232, 234, 236) and out-flow air temperature sensors (242, 244, 246) that respectively measure return air temperatures at inlets and supply air temperatures at outlets of fan coil units (222, 224, 226) located in rooms (203, 205, 207) of the building (202). The HVAC system (200) turns on and off all the compressor (212, 214, 216) based on the return air temperatures and the supply air temperatures.

Abstract: The disclosed techniques improve user engagement and promote efficient use of computing resources by providing dynamically controlled aspect ratios for communication session renderings based on a physical orientation of a device. In some configurations, a system can select a first aspect ratio for individual video streams of a communication session when a device is in a first orientation, e.g., a portrait orientation. In addition, the system can select a second aspect ratio for the individual video streams when the device is in a second orientation, e.g., a landscape orientation. In some configurations, the first aspect ratio can be greater than the second aspect ratio, or the aspect ratios can be selected based on a target aspect ratio, which can be adjusted over time. By dynamically selecting an aspect ratio for individual stream renderings, screen space of a device can be optimized while the device is held in various physical orientations.

Abstract: The disclosed techniques improve user engagement and promote efficient use of computing resources by providing dynamically controlled aspect ratios for communication session renderings based on a physical orientation of a device. In some configurations, a system can select a first aspect ratio for individual video streams of a communication session when a device is in a first orientation, e.g., a portrait orientation. In addition, the system can select a second aspect ratio for the individual video streams when the device is in a second orientation, e.g., a landscape orientation. In some configurations, the first aspect ratio can be greater than the second aspect ratio, or the aspect ratios can be selected based on a target aspect ratio, which can be adjusted over time. By dynamically selecting an aspect ratio for individual stream renderings, screen space of a device can be optimized while the device is held in various physical orientations.

Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.

Abstract: This invention relates to compounds of Formula (I) and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Systems and methods are provided for informing a user about the emotional response of the user to a presentation. Facial expressions of the user are monitored while the user is presented with the presentation. The facial expressions are analyzed to determine an emotion displayed at one or more specific times of the presentation. The user is provided with information about the emotion conveyed by the facial expressions of the user. The user is further provided with an opportunity to take a selected action that corresponds to the emotion conveyed.

Abstract: Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject. Provided also are bacterial formulations for oral or gastric administration to a mammalian subject in an effective amount for prevention or treatment of a gastrointestinal disease, disorder or condition.

Abstract: An elongate hollow tube having two or more fidgets molded onto or attached to an outside surface of said tube is described. The tube can be slipped over a smooth elongated base object, such as a pencil or similar object, to provide manipulatives for students.

Abstract: Techniques are provided for remote object store error handling. A storage system may store data within one or more tiers of storage, such as a local storage tier (e.g., solid state storage and disks maintained by the storage system), a remote object store (e.g., storage provided by a third party storage provider), and/or other storage tiers. Because the remote object store may not provide the same data consistency and guarantees that the storage system provides for clients such as through the local storage tier, additional validation is provided by the storage system for the remote object store. For example, when data is put into an object of the remote object store, a verification get operation is performed to read and validate information within a header of the object. Other verifications and checks are performed such as using a locally stored metafile to detect corrupt or lost metadata and/or objects.