Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK or other kinase inhibitor.

Abstract: The present invention discloses a method for processing an alcoholic beverage in a way that makes the alcohol taste better while taking a minimal amount of time to do so. The method accomplishes this by briefly subjecting the liquid in a container or a tank to a pulse-width modulated EM field having certain characteristics, such as a predetermined average voltage, a duty cycle, fundamental frequency and harmonics thereof and for a determined or certain amount of a time, often in the milliseconds to seconds range. Changing these parameters have a demonstrated greater effect on some compounds in alcoholic beverages than others.

Abstract: A control circuit is provided for a field-effect transistor with a floating source node. The control circuit includes: a charge storage device electrically connected between a gate of the field-effect transistor and a DC power supply; a gate control circuit electrically connected between the charge storage device and the gate of the field-effect transistor; and a charge control circuit electrically connected between the DC power supply and the charge storage device. The gate control circuit is configured to receive a gate control signal and operates to turn on the field-effect transistor during on time of the gate control signal and turn off the field-effect transistor during off time of the gate control signal. The charge control circuit is also configured to receive the gate control signal and operates to charge the charge storage device with power from the DC power supply during off time of the gate control signal.

Abstract: An aerosol provision device for generating aerosol for user inhalation can include a first aerosol generating area and a second aerosol generating area each for receiving an aerosol precursor material; a mouthpiece from which a user inhales generated aerosol during use, wherein the mouthpiece comprises first and second mouthpiece openings; a first pathway extending from the first aerosol generating area to the first mouthpiece opening for transporting a first aerosol generated from the aerosol precursor material in the first aerosol generating area; and a second pathway extending from the second aerosol generating area chamber to the second mouthpiece opening for transporting a second aerosol generated from the aerosol precursor material in the second aerosol generating area, wherein the first and second pathways are physically isolated from one another to prevent mixing of the first and second aerosols as the first and second aerosols are transported along the respective pathways.

Abstract: An aerosol delivery device including a power supply; a vaporizer arranged to selectively receive power from the power supply to generate an aerosol from an aerosol precursor material for user inhalation; and a first electrical interface arranged to provide an electrical connection between the aerosol delivery device and a second aerosol delivery device so as to at least one of: supply power to or receive power from the second aerosol delivery device, or supply control signals to or receive control signals from the second aerosol delivery device.

Abstract: Methods and systems for existing software applications to automatically take advantage of multicore computer systems outside of the conventional simultaneous processing of multiple applications and without performance problems from cache misses and mismatched task processing times are presented. Unlike other multicore optimization techniques, the present invention uses techniques that are applied to design graphs and work for scaled and standard speedup-based parallel processing. The methods and systems optimize software designs that are attached to code for maximum performance on multicore computer hardware by analyzing and modifying loop structures to produce a general parallel solution, not just simple loop unrolling.

Abstract: Aqueous formulations containing active pharmaceutical ingredient and cyclodextrin and their method of preparation and their uses are provided herein

Abstract: A system and method are provided for gathering image data of a surface feature. The system includes cameras and optical elements configured to receive light from an area of a surface having one or more features and to direct the light to the cameras. The system also includes a processor communicatively coupled with the cameras. A memory of the processor includes a sequence of instructions to cause the system to determine 3D calibration data of the cameras; automatically receive image data of the area in focus from the cameras over a plurality of frames; and automatically determine a 3D bitmap image for each frame based on the image data for each frame. The 3D calibration data and 3D bitmap images are stored in the processor memory. A method uses the 3D calibration data and 3D bitmap images to measure one or more parameters of the surface feature.

Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-? enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-? signaling with the compounds and compositions of the disclosure.

Abstract: A snow vehicle having a combined brake and clutch handle is herein disclosed. Further, the snow vehicle can include a controller for managing operation of the snow vehicle, including shifting and engine management regiments, which can be selected by the operator depending upon operator preferences. Additionally, the snow vehicle can include an engine cooling heat exchanger for cooling liquid which is circulated through the engine.

Abstract: Aspects of the disclosure include a 1.5 sided cooled power module for enhanced cooling and gate connections. An exemplary cooled power module can include an upside direct bond copper (DBC) having a first top copper layer, a first bottom copper layer, and a first dielectric layer between the first top copper layer and the first bottom copper layer. A downside DBC includes a second top copper layer, a second bottom copper layer, and a second dielectric layer between the second top copper layer and the second bottom copper layer. One or more dies are positioned between the upside DBC and the downside DBC. The upside DBC is sized such that a portion of an uppermost surface of the one or more dies remains exposed. Bond wires are placed on the exposed portion of the one or more dies and terminated on the first top copper layer of the upside DBC.

Abstract: An SCR catalyst for treating diesel exhaust gas has: a flow-through substrate with an inlet end, an outlet end, a substrate axial length extending from the inlet end to the outlet end and a plurality of passages defined by internal walls of the flow through substrate extending therethrough; a first coating disposed on the internal wall surface of the substrate, the surface defining the interface between the internal walls and passages, the first coating extending over 40 to 100% of the substrate axial length, the first coating having an 8-membered ring pore zeolitic material with copper and/or iron; a second coating extending over 20 to 100% of the substrate axial length, the second coating having a first oxidic material with titania, wherein at least 75 wt. % of the second coating is titania, calculated as TiO2, and 0 to 0.01 wt. % of the second coating is vanadium oxides, calculated as V2O5.

Abstract: Software systems and methods convert algorithms and software codes into time affecting linear pathways (TALPs) via decomposition and convert paired Input/Output (I/O) datasets into TALPs via Value Complexity polynomials. Generated TALPs can be enhanced through merging with other TALPs. TALPs can be grouped by matching the outputs of the TALP-associated prediction polynomials with some set of given criteria into families and cross-families that are useful in a new type of software optimization that allows for output values of grouped TALPs to be modeled, pooled, discretized and optimized to enhance goals or meet user goals.

Abstract: Systems, methods, apparatuses, and computer program products for nonintrusive scanning of objects using X-ray electromagnetic radiation. One method can include generating at least one two-dimensional X-ray radiograph image; generating synthetic flat field data using the at least one two-dimensional X-ray radiograph image, a second two-dimensional X-ray radiograph image, or both; and applying flat field image correction using the synthetic flat field data to the at least one two-dimensional X-ray radiograph image.

Abstract: A snow vehicle having a combined brake and clutch handle is herein disclosed. Further, the snow vehicle can include a controller for managing operation of the snow vehicle, including shifting and engine management regiments, which can be selected by the operator depending upon operator preferences. Additionally, the snow vehicle can include an engine cooling heat exchanger for cooling liquid which is circulated through the engine.

Abstract: Examples of synchronization of a gyroscope in a virtual-reality (VR) environment are described. In some examples, gyroscopic feedback for VR application content may be predicted. In some examples, a time shift corresponding to a physical system lag of a gyroscope may be added to synchronize the gyroscopic feedback with the VR application content. In some examples, the gyroscopic feedback may be applied based on the time shift.

Abstract: Vehicle capture assemblies and related devices, systems, and methods include one or more probe assemblies for engaging with and securing the target vehicle. The one or more probe assemblies may include one or more attenuation features or movable joints to enable and/or dampen movement of the one or more probe assemblies relative to a capture vehicle.

Abstract: Systems, methods, apparatuses, and computer program products for nonintrusive scanning of objects using x-ray electromagnetic radiation. One method may include adjusting, by a computed tomography scanning device, at least one operation parameter including a grey value threshold based upon a material composition of a scan target; and collecting, by the computed tomography scanning device, at least one x-ray frame of the scan target based upon the at least one adjusted operation parameter.

Abstract: Software systems and methods convert algorithms and software codes into time affecting linear pathways (TALPs) via decomposition and convert paired Input/Output (I/O) datasets into TALPs via Value Complexity polynomials. Generated TALPs can be enhanced through merging with other TALPs. TALPs can be grouped by matching the outputs of the TALP-associated prediction polynomials with some set of given criteria into families and cross-families that are useful in a new type of software optimization that allows for output values of grouped TALPs to be modeled, pooled, discretized and optimized to enhance goals or meet user goals.