Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an integrin inhibitor. In particular, the disclosure features the topical treatment of sections and subsections of the gastrointestinal tract by integrin inhibitors (like vedolizumab) using an ingestible device that can detect its whereabouts in the Gl tract by using reflectance and which is programmed to release the drugs at a given site or proximal thereto, to treat gastrointestinal inflammatory diseases. The device has hardware storage devices with instructions on board to determine the location and release the formulations. Combination therapies are claimed as well in which the integrin inhibitor is added systemically and another agent (e.g. JAK inhibitor, TNF-alpha inhibitor or IL-12/IL-23 inhibitor) is added topically by means of the ingestible device. The topical administration is said to reduce the side effects associated with systemic treatment.

Abstract: An aerosol provision system includes one or more receptacles each forming a respective central space, a base adapted to support the or each receptacle, the or each receptacle being removable from the base and at least a first airflow generator, operable to draw air through at least a first aerosol generator, wherein the base includes one or more outlets through which, in operation, aerosolized payload is directed to flow from the base into the central space of a respective receptacle and the or each receptacle comprises a first opening through which the user can inhale the aerosolized payload.

Abstract: This disclosure features methods and compositions for treating inflammatory disorders or conditions that arise in a tissue originating from the endoderm using an immune modulator.

Abstract: In one embodiment, a modular sensor assembly configured for mounting on a vehicle includes a first set of sensors and a second set of sensors. The modular sensor assembly includes a coordinate frame baseplate including a continuous surface, and sensor mounting elements coupled to the continuous surface for mounting the first set of sensors at a first height. The coordinate frame baseplate includes a sensor platform configured for mounting the second set of sensors at a second height. The first set of sensors and the second set of sensors are coupled to the coordinate frame baseplate so as to impart a common coordinate frame for the first set of sensors mounted at the first height and the second set of sensors mounted at the second height. The modular sensor assembly includes a bridging support structure coupled to the coordinate frame baseplate and capable of being mounted on a vehicle.

Abstract: Methods and apparatus for protecting trace data of a remote debug session for a computing system. In one embodiment, a method includes storing trace data received from one or more trace interfaces to a storage location of a target device, where the trace data is generated from execution at the target device, and where the trace data is protected from an unauthorized access. The method continues with transmitting the trace data to a debug host computer with encryption through a communication channel between the target device and the debug host computer.

Abstract: A method for preparing isotopologues and/or stereoisotopomers of cyclic and heterocyclic alkenes and dienes is described. The method provides regio- and/or stereospecific addition of hydrogen, deuterium, tritium and a variety of other substituents to arenes, heteroarenes, and alicyclic compounds that have multiple carbon-carbon double bonds, thereby providing discrete isotopologues and stereoisotopomers of cyclic and heterocyclic alkenes and dienes with high isotopic purity and in high enantiomeric excess. Also described are isotopologues and stereoisotopomers of cyclic and heterocyclic alkenes and dienes, such as isotopologues and stereoisotopomers of cyclohexene and tetrahydropyridine, as well as products thereof, such as isotopologues and stereoisotopomers of piperidines and piperidine-containing compounds, such as methylphenidate. In addition, a method of determining the absolute configuration of stereoisotopomers of cyclohexenes is described.

Abstract: The innovation disclosed and claimed herein, in one aspect thereof, comprises systems and methods of validating models guided by machine learning algorithms. The innovation can begin by receiving a risk model for validation having multiple sets of data. A first data set is selected from as an input. Outputs are generated for validation. One output can be generating a second set of analysis results using a comparable algorithm to the risk model. Another output can be generating a second set of variables and transformations using a machine learning algorithm and an un-transformed set of the selected variables to assess the set of selected transformations. Another output can be generating a third set of variables using one or more machine learning algorithms and an extended feature set of variables to assess the selected variables. The outputs are compared to the analysis results, coefficients, selected variables, and selected transformations. A report of the comparison is generated.

Abstract: In non-limiting examples of the present disclosure, systems, methods and devices for maintaining and interacting with organizational graphs are presented. An organizational graph comprised of nodes including relationship edges may be maintained. The edges may be traversable from one node to another via the relationship data they are defined by. New relationships may be automatically identified amongst organizational entities, and an organizational graph may be automatically updated to reflect those new relationships. An organizational graph may also be updated to reflect organizational relationships that are determined to have been modified and organizational relationships that are determined to no longer exist. User queries may be processed against an organizational graph to identify relevant nodes and their corresponding organizational relationship data.

Abstract: Digital imaging systems and methods are described for analyzing pixel data of an image of a shaving stroke for determining pressure being applied to a user's skin. A plurality of training images of a plurality of individuals are aggregated, each of the training images comprising pixel data of a respective individual when shaving with a shaving razor. A pressure model, trained with the pixel data, is operable to determine pressure being applied to the respective individual's skin. An image of a user when shaving with the shaving razor is received and analyzed, by the pressure model, to determine a user-specific pressure being applied to the user's skin by the shaving razor when a user shaving stroke is taken. A user-specific electronic recommendation to address at least one feature identifiable within the pixel data is generated and rendered, on a display screen of a user computing device.

Abstract: Disclosed embodiments may include an air quality measuring system for determining the environmental risk of indoor pollutants to occupants. The system may include sensors for monitoring a number of airborne pollutants and pathogens. The system may allow a user to interact with the system by scanning a QR code. The system may display, on a user's mobile device, the amount of airborne pollutants in an indoor space. The system may allow the user to share the system's readings by a link, social media post, or public ratings website. The system may be capable of interacting with building smart systems, fire alarms, and HVAC systems. The system may also be capable of sounding an alarm if air quality thresholds are outside a normal range.

Abstract: Digital imaging systems and methods are described for analyzing pixel data of an image of a shaving stroke for determining pressure being applied to a user's skin. A plurality of training images of a plurality of individuals are aggregated, each of the training images comprising pixel data of a respective individual when shaving with a shaving razor. A pressure model, trained with the pixel data, is operable to determine pressure being applied to the respective individual's skin. An image of a user when shaving with the shaving razor is received and analyzed, by the pressure model, to determine a user-specific pressure being applied to the user's skin by the shaving razor when a user shaving stroke is taken. A user-specific electronic recommendation to address at least one feature identifiable within the pixel data is generated and rendered, on a display screen of a user computing device.

Abstract: An approach is provided for a maritime cyber risk assessment profiling tool. The tool accesses a risk profile for one or more maritime vessels, wherein the risk profile includes a plurality of attack vectors targeting a plurality of systems associated with the one or more maritime vessels, and wherein each of the plurality of attack vectors is associated with a quantified risk value. The tool retrieves a risk update from a dynamic risk data source. The tool updates the risk profile based on the risk update, including a first attack vector. The tool causes display of a risk assessment for the one or more maritime vessels based on the updated risk profile, wherein the risk assessment includes risk values assigned for a particular set of the plurality of systems including a risk value that changed based on the update to the first attack vector.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK or other kinase inhibitor.

Abstract: Embodiments are directed to traversing a file system to determine file system objects to copy to an object store. In response to visiting a document object in the file system, performing further actions, including: determining a hierarchical file path of the document object that corresponds to a location in the file system based on the file system objects that are ancestor file system objects of the document object; generating an object key for the document object that encodes the hierarchical file path such that each portion of the object key corresponds to an ancestor file system object; copying the document object and the object key to the object store such that the document object may be stored in the object store as an object store object and such that the object store object may be indexed using an unordered index based on the object key; or the like.

Abstract: Embodiments are directed to managing data in a file system over a network. A source file system that includes a plurality of objects may be provided. A replication job that copies each object associated with a source replication snapshot to a target file system may be executed. The replication job may be associated with a job identifier. Recovery point information that includes the job identifier, a source snapshot number that corresponds to the source replication snapshot, a target snapshot number that corresponds to a target replication snapshot may be generated. The recovery point information may be stored on the source file system and a copy of the recovery point information may be stored on the target file system. The recovery point information or the copy of the recovery point information may be employed to recover from errors detected during execution of a next replication job.

Abstract: An autonomous grain cart includes a width less than or equal to a distance from an end of the header of an agricultural vehicle to a lateral side of the agricultural vehicle, wherein the end and the lateral side are on a same longitudinal side of a lateral centerline of the agricultural vehicle, wherein the autonomous grain cart is configured to receive grain from the agricultural vehicle. The autonomous grain cart also includes a controller, comprising a processor and a memory. The autonomous grain cart further includes a drive system communicatively coupled to the controller, wherein the controller is configured to instruct the drive system to propel the autonomous grain cart. The autonomous grain cart also includes a steering system communicatively coupled to the controller, wherein the controller is configured to instruct the steering system to steer the autonomous grain cart.

Abstract: Examples of synchronization of a gyroscope in a virtual-reality (VR) environment are described. In some examples, gyroscopic feedback for VR application content may be predicted. In some examples, a time shift corresponding to a physical system lag of a gyroscope may be added to synchronize the gyroscopic feedback with the VR application content. In some examples, the gyroscopic feedback may be applied based on the time shift.

Abstract: A method for modifying visual aspects of a keyboard in response to a user typing on the keyboard. The method includes one or more computer processors receiving a first character input to an input device. The method further includes determining a plurality of words that begin with the first received character. The method further includes ranking the determined plurality of words. The method further includes selecting a word from among the ranked plurality of words based on a first set of criteria. The method further includes determining a sequence of one or more characters after the received first character that correspond to the selected word. The method further includes modifying one or more respective characteristics of input elements of the input device that correspond to the sequence of characters of the selected word.

Abstract: An orientation sub includes a pair of connectors that consists of a first connector and a second connector with the first connector. A center section joins the first connector to the second connector. The second connector connects the orientation sub to a tool. The center section has a predetermined geometric configuration with that self-orients the tool when the orientation sub and the tool are inserted into a well defined by casing.

Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a S1P modulator.