Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof: wherein Het, X1, X2, L, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly for use in treating disorders associated with CD38 activity.

Abstract: An improved light fixture includes a housing that connects to a power source at one end and interfaces with a heat sink, lighting module, and associated lens at the other end. A lens retainer includes an aperture that allows water to flow into a cavity formed within the lens retainer when installed. A portion of the heat sink is exposed to the cavity and can form a surface of the cavity. As a result, the exposed surface of the heat sink can come into direct contact with water that flows through the aperture of the lens retainer. The lens retainer can use multiple apertures in fluid communication with the cavity, providing a path for water to provide a cooling flow to the heat sink.

Abstract: Examples described herein include systems and methods for improved water level management in a body of water, such as a pool, spa, or pond. An example system includes a water sensor in a static pipe connected to a body of water, a processor receiving signals from the sensor, a memory, and a battery charged via a low-power data channel. When the sensor detects a low-water-level condition, the system opens a fill valve to add water to the body of water. An ultraviolet light can illuminate a portion of the pipe for purposes of preventing algae growth, and an orientation sensor provides a level of safety by deactivating the light for orientations outside a threshold range that could indicate installation or maintenance on the system. The system components can all be contained in a housing that can be mounted to an end of the static pipe.

Abstract: Examples described herein include systems and methods for improved acid-dispensing for pools. An example method can include drawing electrical current at the device through a low-power data channel to charge a battery. The example method can also include receiving at the device, through the data channel, a digital signal instructing the device to dispense acid. The digital signal can include an indication of an amount of acid to be dispensed by the acid-dispensing device. The acid-dispensing device can authenticate the digital signal and discharge acid based on the signal. For example, discharging acid can be performed by powering a pump using energy stored in the battery of the device. In some examples, the acid-dispensing device can confirm water flow to the pool before discharging acid.

Abstract: Examples described herein include systems and methods for improved acid-dispensing for pools. An example method can include drawing electrical current at the device through a low-power data channel to charge a battery. The example method can also include receiving at the device, through the data channel, a digital signal instructing the device to dispense acid. The digital signal can include an indication of an amount of acid to be dispensed by the acid-dispensing device. The acid-dispensing device can authenticate the digital signal and discharge acid based on the signal. For example, discharging acid can be performed by powering a pump using energy stored in the battery of the device. In some examples, the acid-dispensing device can confirm water flow to the pool before discharging acid.

Abstract: Systems and methods for smart valve control of pool and spa components and operations are provided. A smart valve system is provided which includes a multiplexed communications link between the smart valve system and a pool/spa control system which allows for a plurality of relays of the pool/spa control system to control a plurality of valves of the smart valve system using a single data communications cable connected between the smart valve system and the pool/spa control system. The smart valve system allows for calibration and control of a pumping system, such as a variable speed pumping system. The smart valve system optimizes operation and heat transfer of a solar heater in fluid communication with the smart valve system. The smart valve system allows for control and optimization of a pool cleaner in fluid communication with the smart valve system. The smart valve system allows for control and optimization of a gas heater in fluid communication with the smart valve system.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts, N-oxides, solvates and prodrugs thereof Formula (I) wherein R2, R3, R4, X1, X2, X3 and X4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, particularly for use in treating disorders associated with KCNK13 activity.

Abstract: Sensor data can be collected from a first set of sensors associated with a first seat within a vehicle during a first vehicle stage. The outputs of each sensor of the first set of sensors can then be aggregated to calculate a probability of life within the first seat during the first vehicle stage.

Abstract: A valve assembly includes a first housing that defines an inlet and a fluid output chamber. A second housing is engaged to the first housing and a cover is engaged to the second housing. A valve member is positioned within the first housing. An actuator is positioned between the second housing and the cover and is attached to the valve member through an engagement located within the first housing. A flow rate sensor, as a component of the valve assembly, may be positioned downstream of the inlet and the fluid output chamber.

Abstract: A first valve of a manifold for a fluid distribution system (“FDS”) regulates fluid flow to a first fluid handling device (“FHD”). A second valve of the manifold may communicate with a second FHD, reservoir, or recirculation line. A target flow condition for the manifold may be determined by a manifold control system (“MCS”) based on a device setting received from the first FHD. The MCS may determine an operation of the FDS based on the target flow condition, fluid flowrate, and supply device operational state. The operation may include the MCS controlling the supply device, first valve, and/or second valve to change the flowrate. The MCS may continuously operate a valve to maintain the target flow condition once exhibited. Fluid distribution systems, systems and methods for turning over an FDS including a manifold, and systems and methods for controlling operations of an FDS including multiple manifolds are also provided.

Abstract: Disclosed herein is mouth guard including a structural component having an arch portion including pre-formed tooth-receiving indentations; and a conforming component supported by the structural component and being displaceable between the teeth of a wearer and the tooth-receiving indentations only when at or above a threshold temperature. Also disclosed is a computer-implemented method for recommending a mouth guard, and a computer-implemented method for determining bite dimensions for each of a plurality of mouth guards.

Abstract: Systems and methods for dynamically controlling chlorinator operations based on chlorine demand may include receiving an operation command associated with a chlorinator for a fluid system with a chlorinator operation management controller (“management controller”). The management controller may determine a remaining runtime for the chlorinator and access measured values for fluid conditions from a plurality of fluid condition sensors for fluid of the fluid system. The management controller may determine a current chlorine demand based on the measured fluid conditions and a predetermined threshold for a chlorine level for the fluid. An operation of the chlorinator between an active state and an inactive state may be caused by the controller based on the current chlorine demand, the remaining runtime, and a configuration of components for the fluid system. Causing the operation of the chlorinator may include managing operations of a legacy control for the chlorinator.

Abstract: A housing assembly for a manifold includes a first housing with an inlet and a plurality of outlets, a second housing, and a valve retainer engaged with the first and second housings. The valve retainer includes a retention plate defined between first and second surfaces, a plurality of slot walls extending from the first surface, and a protruding edge that extends from a flanged lip and surrounds the plurality of slot walls. The retention plate defines a plurality of slots corresponding to the plurality of slot walls. The first housing may define a groove that receives the protruding edge, and the second housing may include a rim that engages the flanged lip of the valve retainer. Valve housings including first and second mating structures separated by wall segments may be positioned in outlets of the first housing and corresponding slots of the valve retainer.

Abstract: A sensor assembly may include a chassis, cover, first sensor, second sensor, and a control system. The chassis may include a first housing that defines a chamber with the cover and includes a partition within the chamber. A second housing of the chassis may define first and second ports in fluid communication with the chamber. A central wall may extend from an inner surface of the second housing and a protruding wall may extend over the central wall. Both the partition and the central wall may extend from locations along a longitudinal axis of the sensor assembly that are between the first port and the second port. In some examples the protruding wall and the partition direct a portion of fluid flowing within the second housing into and out of the chamber, and the first and second sensors detect values for respective fluid parameters for the portion of fluid.

Abstract: A method, computer program product and computer system to calculate resource quotas in a distributed computing environment are provided. A processor retrieves workload data regarding a plurality of workloads in a shared computing environment, where the plurality of workloads are executing or pending execution within the shared computing environment. A processor identifies a plurality of tenants of the shared computing environment associated with the plurality of workloads. A processor determines an expected resource usage for the plurality of tenants. A processor determines a ratio of resource usage for the plurality of tenants. A processor determines a resource limit for the plurality of tenants. A processor adjusts at least one aspect of the shared computing environment based on a determination that a total expected resource usage for both executing and pending workloads of a tenant exceeds a resource limit associated with the tenant.

Abstract: A system and method for controlling operations of a fluid distribution may include a first manifold receiving a next mode of operation for the fluid distribution system. The first manifold may calculate first and second flow requirements for the first and second manifolds that may respectively include a first and second total flowrates from the first and second manifolds. The first manifold may determine required operation states for valves of the first manifold and the second manifold for the next mode based on the first and second flow requirements. The first manifold may be controllably operated to cause the second manifold and a supply device of the fluid distribution system to operate in the required operation states and provide first and second flow requirements. The first manifold may direct the second manifold to independently balance individual outlet flowrates of the second manifold while continuing to provide the second flow requirements.

Abstract: A first valve of a manifold for a fluid distribution system may regulate a fluid flow to a first fluid handling device (“FHD”). A second valve of the manifold may communicate with a second FHD, a reservoir, or a recirculation line. A target flow condition for the manifold may be determined by a manifold control system (“MCS”) based on a device setting received for the first FHD. The MCS may determine a fluid distribution system operation for obtaining the target flow condition based on the target flow condition, a flowrate of the fluid flow, and an operational state of a supply device. The operation may include the MCS controlling at least one of the supply device, the first valve, and the second valve to change the flowrate. The MCS may continuously operate at least one manifold valve to maintain the target flow condition once exhibited by the manifold.

Abstract: A fluid distribution manifold may receive a first required flow rate for a first flow of fluid that flows to a fluid handling device or a reservoir. A first operation state may be determined for a first valve assembly that regulates the first flow, the manifold may operate the first valve assembly based on the first operation state, and a first position tracker may be incremented based on the first operation. Based on a value of a cycle tracker, the manifold may identify a second valve assembly in an operation cycle and access a second control input that includes a second required flow rate for a second flow of fluid regulated by the second valve assembly. The manifold may cause the second valve assembly to operate based on at least one of a second operation state and a change in the second actual flow rate resulting from the first operation.

Abstract: A manifold can determine a turnover scheme including a target turnover schedule of target turnover levels, based on an operation schedule and efficiency setting for a fluid distribution. Each target turnover level can correspond to a volume of fluid to be cycled through the fluid distribution system over a period of time. The manifold can operate respective valves and a supply device based on a target turnover level and determine a current turnover level from a flowrate detected by a flow sensor for at least one of the valves. The manifold can receive a current usage of the fluid distribution system and determine a required turnover level. An override status for the turnover scheme can be based on the efficiency setting and a comparison of the current, target, and the required turnover levels, and the manifold can operate respective valves and the supply device based on the override status.

Abstract: A manifold can determine a turnover scheme including a target turnover schedule of target turnover levels, based on an operation schedule and efficiency setting for a fluid distribution. Each target turnover level can correspond to a volume of fluid to be cycled through the fluid distribution system over a period of time. The manifold can operate respective valves and a supply device based on a target turnover level and determine a current turnover level from a flowrate detected by a flow sensor for at least one of the valves. The manifold can receive a current usage of the fluid distribution system and determine a required turnover level. An override status for the turnover scheme can be based on the efficiency setting and a comparison of the current, target, and the required turnover levels, and the manifold can operate respective valves and the supply device based on the override status.