Abstract: In one embodiment, a computing device may determine a virtual content to be displayed with a scene of a real-world environment. The device may generate an image depicting the virtual content. Using one or more sensors, the device may detect characteristics of the scene of the real-world environment. Based on the image and the characteristics of the scene, the device may determine that a visual enhancement is to be applied to the virtual content depicted in the image to enhance a contrast between the depicted virtual content and the scene. The device may generate a visually-enhanced image depicting the virtual content by applying the visual enhancement to the virtual content depicted in the image. The device may display the visually-enhanced image of the virtual content on a display of the computing device, wherein the scene of the real-world environment is visible through the display.

Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.

Abstract: Eye and hand tracking systems in head-mounted display (HMD) devices are arranged with lensless camera systems using optical masks as encoding elements that apply convolutions to optical images of body parts (e.g., eyes or hands) of HMD device users. The convolved body images are scrambled or coded representations that are captured by a sensor in the system, but are not human-recognizable. A machine learning system such as a neural network is configured to extract body features directly from the coded representation without performance of deconvolutions conventionally utilized to reconstruct the original body images in human-recognizable form. The extracted body features are utilized by the respective eye or hand tracking systems to output relevant tracking data for the user's eyes or hands which may be utilized by the HMD device to support various applications and user experiences. The lensless camera and machine learning system are jointly optimizable on an end-to-end basis.

Abstract: Electric vehicle predictive range estimating systems and methods are provided herein. An example method includes determining an initial state of charge (SOC) for an energy source of a vehicle at a first point in time; determining one or more boundary conditions for the vehicle during a time frame extending from the first point in time to a second point in time, the one or more boundary conditions causing a loss in the energy source during the time frame; determining a predicted future SOC for the energy source based on the one or more boundary conditions and the initial SOC; and predicting an availability of a vehicle operating condition based on the predicted future SOC for the energy source.

Abstract: The present invention relates to a method of treating seizures using cannabidiol (CBD), which significantly shortens the dose titration period. This results inpatients receiving maintenance doses sooner after initiating treatment, which reduces the occurrence of breakthrough seizures and improves adherence to treatment.

Abstract: A molded housing of a conformal wearable battery (CWB) encloses an electronic component and include an electrically conductive contact component embedded within an exterior wall to conduct electricity between an interior and an exterior of the casing. A flexible printed circuit board assembly (PCBA) for a conformal wearable battery (CWB) is enclosed in a cavity within the molded housing and includes attachment sections for a plurality of battery cells that are arranged in a grid-like pattern on a same side of the flexible PCBA. A visco-elastic shock-absorbing member installed between the upper and lower portion of the flexible PCBA when configured in a folded configuration. Each battery cell is joined to the flexible PCBA via a welding process. Each battery cell has a visco-elastic shock-absorbing member attached individually to each battery cell of the plurality of battery cells.

Abstract: In embodiments, a computer system produces a first resource for a first dataset having a time indicator, by applying a first digital rule. A first notification can be caused to be transmitted about an aspect of the first resource to a remote device. A second dataset can be stored, which has values derived from the first dataset, and encodes a parameter of the first resource. A second digital rule may be stored to replace the first digital rule, at an updating time (Tupd). The second digital rule may have an effective time (Teff) prior to the actual updating time Tupd. A second resource may be produced by applying the second digital rule. A second notification can be caused to be transmitted about an aspect of the second resource to a remote device.

Abstract: A hemodynamic monitor for detecting nociception of a patient includes a non-invasive blood pressure sensor with an inflatable blood pressure bladder, a pressure controller pneumatically connected to the inflatable blood pressure bladder, and an optical transmitter and an optical receiver that are electrically connected to the pressure controller. The hemodynamic monitor also includes an integrated hardware unit with a system processor, a system memory, and a display with a user interface.

Abstract: A technique is described for evaluating code at a local computing device before deploying the code to a cloud computing platform to be compiled. In an example embodiment, class files including the code in a programming language associated with the cloud computing environment are loaded by a local computer system, for example, associated with a software developer. The local computer system then parses the code to identify elements in the code and checks the identified elements. Errors in the code are identified based on the checking and are displayed to a user (e.g., the developer), for example, via a graphical user interface of a code editor application.

Abstract: This invention relates generally to compositions for making C A Vectors and uses thereof.

Abstract: Systems, methods, and devices are described herein for placing secondary content into a break of unknown duration in a stream of primary content. In one aspect, the described techniques may include streaming a segment of primary content, for example, by a reduce capability client device, such as a mobile device or tablet. The device may receive information indicative of a break in the streaming of the primary content. The device may play secondary content based on receiving the information indicative of the break. The device may determine when a next segment of the primary content is available, and begin streaming the next segment of the primary content upon detecting that the second segment of the primary content is available.

Abstract: Techniques and systems are provided for positioning mixed-reality devices within mixed-reality environments. The devices, which are configured to perform inside out tracking, transition between position tracking states in mixed-reality environments and utilize positional information from other inside out tracking devices that share the mixed-reality environments to identify/update positioning of the devices when they become disoriented within the environments and without requiring an extensive or full scan and comparison/matching of feature points that are detectable by the devices with mapped feature points of the maps associated with the mixed-reality environments. Such techniques can conserve processing and power consumption that would be required when performing a full or extensive scan and comparison of matching feature points. Such techniques can also enhance the accuracy and speed of positioning mixed-reality devices.

Abstract: Described herein are pharmaceutical compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto. Also described are compositions comprising 2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3-yl}-N-[(3S,5S)-5-fluoropiperidin-3-yl]pyrimidine-5-carboxamide, or pharmaceutically acceptable salt thereof and 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4?-piperidine]-1?-carbonyl)-6-methoxypyridin-2-yl)benzoic acid, or pharmaceutically acceptable salt thereof, for treatment of liver disease and diseases related thereto.

Abstract: A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.

Abstract: Adhesive formulations for forming a fluorinated poly(imide-phthalonitrile) thermoset polymer are provided. Such an adhesive formulation may comprise a fluorinated imide-phthalonitrile oligomer having Formula IV wherein R1 is an unsubstituted or substituted aryl group and does not comprise an ether group; R2 is an unsubstituted or substituted aryl group and does not comprise an ether group; at least one of R1 and R2 comprises a fluorine substituent; and n has a value of from 1 to 30.

Abstract: An air filter assembly includes a filter element having at least one variable dimension, and a frame for engaging and supporting the filter element. The frame may include a plurality of linear segments forming a rectangular configuration, and a plurality of clips for connecting the linear segments together at corners thereof. The linear segments may be L-channel segments, C-channel segments, or may be of other form. Clips may be used for connecting the linear segments together at the corners. The filter element may have a pattern of creases or fold lines to facilitate folding thereof from an expanded configuration to a reduced configuration. A grate may be included for spanning an area bounded by the frame to support the filter element. The grate may have multiple arms and a central hub. An edge treatment may form a seal between the filter element and the frame.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced inpatients diagnosed with a SPATA5 mutation. In a further embodiment the types of seizures include tonic, myoclonic and focal seizures with impairment. Preferably the dose of CBD is between mg/kg/day to 50 mg/kg/day.

Abstract: The present invention relates to the use of cannabidiol (CBD) for the treatment of seizures associated with rare epilepsy syndromes. In particular the seizures associated with rare epilepsy syndromes that are treated are those which are experienced in patients diagnosed with encephalocele. In a further embodiment the types of seizures include absence, focal seizures with secondary generalisation and focal seizures with impairment. Preferably the dose of CBD is between 5 mg/kg/day to 50 mg/kg/day.

Abstract: Example portable grills having reversible steam tray assemblies are disclosed. An example portable grill includes a cookbox, a heating element, a water pan, and a steam tray. The heating element is located within the cookbox. The water pan is located within the cookbox above the heating element. The water pan includes a bottom wall. The steam tray is located within the water pan. The steam tray includes a horizontally-oriented support wall having a plurality of openings extending therethrough. The steam tray is configured to be reversibly positioned within the water pan in a first orientation and a second orientation. The support wall is spaced from the bottom wall by a first distance when the steam tray is positioned in the first orientation. The support wall is spaced from the bottom wall by a second distance greater than the first distance when the steam tray is positioned in the second orientation.

Abstract: The present disclosure relates to certain (2,S)-N-[(1,S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.