Abstract: Systems, devices, and methods are described herein for distributing syndicated content or content with one or more distribution restrictions. In one aspect, a method may include assigning a unique ID to a plurality of content items, where the unique ID of at least one of the content items is associated with one or more property distribution restrictions. The method may further include streaming in a video stream the content items to at least two properties and monitoring the unique IDs of the plurality of content items streamed in the video stream to detect least one content item associated with the one or more property distribution restrictions. The distribution of the least one content item associated with the one or more property distribution restrictions may be blocked from the one or more properties concurrently with streaming the video stream, based on the one or more property distribution restrictions.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as branched-chain alpha keto acid dehydrogenase kinase inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, diabetes, kidney disease, NASH and heart failure.

Abstract: Example methods and apparatus for presenting safety-based temperature status notifications for grills are disclosed. An example grill includes a controller to determine whether a condition indicative of a safety-based temperature status of the grill is satisfied. In response to determining that the condition is satisfied, the controller is to instruct a lighting module or a user interface of the grill to present a notification indicating the safety-based temperature status.

Abstract: Techniques are described herein for optimizing the presentation of content through obtaining viewership metrics, generating multiple renditions of presentations of content, and selecting optimized renditions of content. One aspect includes associating a request for viewership metrics with a presentation of content, publishing the presentation of content, and receiving information of the viewership metrics associated with the presentation. Another aspect includes copying a presentation of a content item, creating a second presentation of the content item for publishing over one or more channels, and linking the presentation of the content item to the second presentation of the content item, such that a change to one propagates to the other of the presentation of the content item or the second presentation of the content item. In yet another aspect, a content rendition may be selected for presentation based on performance of the rendition out of multiple renditions in an auction.

Abstract: A device for treating a tissue opening includes a proximal portion including an elongated flexible member, a capsule releasably coupled to a distal end of the flexible member and including a lumen extending therethrough and a clip including a pair of arms movably housed within the capsule. A suture extending along a first one of the pair of arms and including a loop at a distal end thereof extending across an opening extending through the first one of the pair of arms. A suture grabbing element extending laterally from a second one of the pair of arms and including a hook so that, when the pair of arms are moved toward a closed configuration, the hook extends through the opening to grab the loop and draw the distal end of the suture from the first one of the pair of arms toward the second one of the pair of arms.

Abstract: The present disclosure generally relates to prefetching data from one or more CPUs prior to the data being requested by a host device. The prefetched data is prefetched from memory and stored in cache. If a host device requests data that is not already in cache, then a determination is made regarding whether the data is scheduled to be written into cache. If the data is not in cache and is not scheduled to be written into cache, then the data is retrieved from memory and delivered to the host device. If the data is scheduled to be written into cache, or is currently being written into cache, then the request to retrieve the data is delayed or scheduled to retrieve the data once the data is in cache. If the data is already in cache, the data is delivered to the host device.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present disclosure relates to certain (2S)—N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: Methods, systems and devices are provided which transmit energy to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.

Abstract: A method may include identifying, by one or more processors, an object in a field of view of a wearable display, where the object is identified for a presbyopic compensation. The presbyopic compensation is performed by the one or more processors on image data of the object to generate compensated image data of the object. The one or more processors render an image in response to the compensated image data of the object on a display of the wearable display.

Abstract: The present disclosure relates to the use of cannabidiol (CBD) for the treatment of atonic seizures. In particular the CBD appears particularly effective in reducing atonic seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; Doose Syndrome; Aicardi syndrome; CDKL5 and Dup15q in comparison to other seizure types. The disclosure further relates to the use of CBD in combination with one or more anti-epileptic drugs (AEDs).

Abstract: A dataflow graph has operation units that are configured to be producer operation units to produce tensors for execution of the application, and to be consumer operation units to consume the tensors for execution of the application. Compile time logic is configured to process the dataflow graph to determine, for the tensors, expected producer memory layouts, expected consumer memory layouts, and current memory layouts. The expected producer memory layouts specify memory layouts required by the producer operation units that produce the tensors. The expected consumer memory layouts specify the memory layouts required by the consumer operation units that consume the tensors. The current memory layouts specify the memory layouts of the tensors. Each of the memory layouts includes a vector dimension and at least one of a vector ordering and a data alignment.

Abstract: Systems, devices, and methods are described herein for distributing syndicated content or content with one or more distribution restrictions. In one aspect, a method may include assigning a unique ID to a plurality of content items, where the unique ID of at least one of the content items is associated with one or more property distribution restrictions. The method may further include streaming in a video stream the content items to at least two properties and monitoring the unique IDs of the plurality of content items streamed in the video stream to detect least one content item associated with the one or more property distribution restrictions. The distribution of the least one content item associated with the one or more property distribution restrictions may be blocked from the one or more properties concurrently with streaming the video stream, based on the one or more property distribution restrictions.

Abstract: Among other things, one or more techniques and/or systems are provided for providing users with access to a route for travelling. A user, of a client device, may send a request for access to the route to a route planning service. The route may correspond to a starting location and an ending location. The route planning service may query a route database to identify an entry indicating that a restricted access road segment (e.g., a high occupancy vehicle lane, a shoulder lane, a bus lane, etc.) and/or a road segment (e.g., comprising a traffic light alteration capability) exists between the starting location and the ending location. Responsive to successfully authorizing the user for travelling the restricted access road segment and/or the road segment, the route, comprising the restricted access road segment and/or the road segment, may be provided to the client device.

Abstract: The disclosure provides novel solid state forms of Compound I chosen from Compound I Phosphate Salt Hydrate Form A, Compound I free form Monohydrate, Compound I Phosphate Salt Methanol Solvate, and Compound I Phosphate Salt MEK Solvate, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease). Also provided herein are novel solid state forms of Compound II chosen from Compound II Phosphate Salt Hemihydrate Form A, Compound II free form Hemihydrate Form A, and Compound II free form Form C, compositions comprising the same, and methods of making and using the same, including uses in treating APOL1 mediated disease (such as, e.g., APOL1 mediated kidney disease).

Abstract: According to one aspect, a medical system may include an instrument including an end effector for acting as a monopolar electrode. The end effector may be configured to be positioned in a body of a subject and emit radiofrequency energy towards a target area in the body. The medical system may further include a return electrode. The return electrode may be deliverable within the body proximate the target area and separately from the instrument and the monopolar electrode. The return electrode may be configured to contact tissue in the body proximate the target area and receive radiofrequency energy emitted from the end effector.

Abstract: Techniques for managing a multi-marketplace content presentation are described herein. For example, a computer system indicates, via a graphical user interface at a device associated with an account identifier, multiple web sites that offer an item for which content is to be presented. The computer system receives input indicating a selection of a set of web sites of the multiple web sites. The computer system receives a first control and a first target associated with presenting the content in the set of web sites and generates a second control and a second target. The computer system indicates the item and a first metric associated with presenting the content in the web sites based on the first control and the first target. The computer system indicates the selected web site and a second metric associated with presenting the content in the selected web site.