Patents by Inventor Kevin Paul

Kevin Paul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9233859
    Abstract: The present invention provides a system for solvent extraction utilizing a first electrode with a raised area formed on its surface, which defines a portion of a microfluidic channel; a second electrode with a flat surface, defining another portion of the microfluidic channel that opposes the raised area of the first electrode; a reversibly deformable substrate disposed between the first electrode and second electrode, adapted to accommodate the raised area of the first electrode and having a portion that extends beyond the raised area of the first electrode, that portion defining the remaining portions of the microfluidic channel; and an electrolyte of at least two immiscible liquids that flows through the microfluidic channel. Also provided is a system for performing multiple solvent extractions utilizing several microfluidic chips or unit operations connected in series.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: January 12, 2016
    Assignee: UCHICAGO ARGONNE, LLC.
    Inventors: Artem Gelis, Candido Pereira, Kevin Paul Flood Nichols
  • Publication number: 20160000756
    Abstract: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
    Type: Application
    Filed: July 13, 2015
    Publication date: January 7, 2016
    Inventors: Weiwen Ying, Zhenjian Du, Kevin Paul Foley
  • Patent number: 9215131
    Abstract: A network access device (NAD) receives a UDP packet from a client to be transmitted to a management server over Internet, the UDP packet including a management message. The NAD is one of NADs managed by the management server. The NAD determines whether the management server is reachable using a UDP protocol. The NAD transmits the UDP packet to the management server using the UDP protocol over the Internet if it is determined that the management server is reachable using the UDP protocol. Otherwise, the NAD extracts a UDP payload from the UDP packet, encapsulates the UDP payload within an HTTP POST request, and transmits the HTTP POST request having the UDP payload encapsulated therein to the management server using a HTTP protocol over the Internet.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: December 15, 2015
    Assignee: CISCO TECHNOLOGY, INC.
    Inventors: Clifford A. Frey, John Bicket, Kevin Paul Herbert, Varun Sagar Malhotra, Benjamin A. Chambers
  • Patent number: 9205086
    Abstract: A pharmaceutical combination comprising an EGFR inhibitor and an Hsp90 inhibitor according to the following formulae (I) or (Ia) a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables in the structural formulae are defined herein. Also provided are methods for treating a proliferative disorder in a subject in need thereof using pharmaceutical combinations disclosed herein.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: December 8, 2015
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Ronald K. Blackman, Kevin Paul Foley, David Proia
  • Patent number: 9206162
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: December 8, 2015
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Kowalczyk-Przewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
  • Patent number: 9156794
    Abstract: Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell. Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: October 13, 2015
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Weiwen Ying, Zhenjian Du, Kevin Paul Foley
  • Patent number: 9161080
    Abstract: Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: October 13, 2015
    Assignee: LEVEL 3 COMMUNICATIONS, LLC
    Inventors: James Q. Crowe, John F. Waters, Jr., Andrew Dugan, Christopher Newton, Laurence Lipstone, Kenneth Brookman, Joseph Lawrence, Andrew Swart, David Fullagar, Kevin Paul, Mark Taylor
  • Publication number: 20150266858
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Application
    Filed: April 13, 2015
    Publication date: September 24, 2015
    Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Kowalczyk-Przewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
  • Patent number: 9108933
    Abstract: The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating c-Met associated cancers, in a subject in need thereof.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: August 18, 2015
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Zhenjian Du, Kevin Paul Foley
  • Publication number: 20150227936
    Abstract: A system for providing real-time risk mitigation for an authorization system. The system receives authorization requests from multiple merchants (or their respective acquirers) and processes such requests. Each processed request is then forwarded to its corresponding issuer for further authorization. Each processed request includes an authorization message. The authorization message can include a risk score, a number of reason codes, and a number of condition codes. The use of the risk score, reason codes and condition codes allows issuers to make better informed decisions with respect to providing authorizations.
    Type: Application
    Filed: April 21, 2015
    Publication date: August 13, 2015
    Inventors: Belva J. Bruesewitz, Nancy Hilgers, Patrick L. Faith, Kevin Paul Siegel, Xiaoli Li, Krishna Prasad Koganti, Craig O'Connell
  • Publication number: 20150182936
    Abstract: Systems and methods for synthesizing high-quality nanocrystals via segmented, continuous flow microwave-assisted reactor were developed.
    Type: Application
    Filed: December 24, 2014
    Publication date: July 2, 2015
    Inventors: Ki-Joong Kim, Eric Bradley Hostetler, Gregory Scott Herman, Daniel Alan Peterson, Chih-hung Chang, Brendan Thomas Flynn, Brian Kevin Paul, Richard Paul Oleksak, Padmavathi Chandran, Bob C. Fitzmorris, Gustavo Henrique Albuquerque
  • Publication number: 20150174466
    Abstract: A game bag comprising a housing forming an enclosure for storing game balls or pucks therein. The housing has an opening disposed in a front side thereof for receiving/dumping the game balls or pucks. A ramp cover is pivotally movable connected to the housing. The ramp cover covers the opening in a closed position and forms a ramp in an open position. A dumping handle is connected to the housing and disposed in proximity to a rear side of the housing for holding the game bag with the rear side up for dumping the game balls or pucks.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 25, 2015
    Applicant: Kevin Paul Folland and Kevin Joseph Gallant, a Partnership
    Inventor: Kevin Paul Folland
  • Patent number: 9031860
    Abstract: In one aspect, a computing apparatus includes: a data warehouse to store data associating a plurality of account identifiers with an offer having a predefined purchase requirement and an aggregated purchase requirement for a benefit; and a transaction handler configured to process a plurality of transactions. The transaction handler is further configured to determine whether each of the plurality of transactions satisfies a predefined purchase requirement, identify a set of transactions each satisfying the predefined purchase requirement, and determine whether the set of transactions satisfies an aggregated purchase requirement for the benefit. In one example, the transaction handler is configured to provide the benefit via statement credits when the set of transactions satisfies the aggregated purchase requirement.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: May 12, 2015
    Assignee: Visa U.S.A. Inc.
    Inventors: Michelle Eng Winters, Alfred William Griggs, Laura DiGioacchino, Diane C. Salmon, Kevin Paul Siegel, Kaushik Subramanian, James Alan VonDerheide, Edward W. Fordyce, III, Leigh Amaro
  • Publication number: 20150112490
    Abstract: The present disclosure relates to methods and systems that may be used to alter the permeability of a biological object. In some embodiments, the methods and systems may be used to alter the permeability of a non-human embryo. In some embodiments, the methods and systems may be used to alter the permeability of an insect embryo. In some embodiments, the methods and systems may be used to alter the permeability of a mosquito embryo.
    Type: Application
    Filed: October 23, 2013
    Publication date: April 23, 2015
    Applicant: TOKITAE LLC
    Inventors: Ryan Calderon, Cary Richard Champlin, David Gasperino, Emma Rae Mullen, Kevin Paul Floods Nichols, David Keith Piech
  • Patent number: 9006277
    Abstract: The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: April 14, 2015
    Assignee: Synta Pharmaceuticals Corp.
    Inventors: Lijun Sun, Weiwen Ying, Junghyun Chae, Teresa Kowalczyk-Przewloka, Shijie Zhang, Dinesh U. Chimmanamada, Kevin Paul Foley, Zhenjian Du, Hao Li, David James, Howard P. Ng, Zachary Demko, Dan Zhou, Shuzhen Qin
  • Publication number: 20150094349
    Abstract: The present invention relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating Bcr-Abl, FLT-3, EGFR, c-Kit, B-raf, and NPM-ALK associated cancers, in a subject in need thereof.
    Type: Application
    Filed: December 11, 2014
    Publication date: April 2, 2015
    Inventors: Zhenjian Du, Kevin Paul Foley
  • Publication number: 20150090596
    Abstract: The present invention provides a system for solvent extraction utilizing a first electrode with a raised area formed on its surface, which defines a portion of a microfluidic channel; a second electrode with a flat surface, defining another portion of the microfluidic channel that opposes the raised area of the first electrode; a reversibly deformable substrate disposed between the first electrode and second electrode, adapted to accommodate the raised area of the first electrode and having a portion that extends beyond the raised area of the first electrode, that portion defining the remaining portions of the microfluidic channel; and an electrolyte of at least two immiscible liquids that flows through the microfluidic channel. Also provided is a system for performing multiple solvent extractions utilizing several microfluidic chips or unit operations connected in series.
    Type: Application
    Filed: October 30, 2013
    Publication date: April 2, 2015
    Applicant: UCHICAGO ARGONNE, LLC
    Inventors: Artem Gelis, Candido Pereira, Kevin Paul Flood Nichols
  • Patent number: 8994670
    Abstract: A method includes detecting a first touch at a first touch location on a touch-sensitive display, detecting a second touch at a second touch location on the touch-sensitive display, and when a first distance from the first touch location to the second touch location meets a distance threshold and a second distance from the previous touch location to the first touch location does not meet the distance threshold, identifying the second touch as a new touch.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: March 31, 2015
    Assignee: Blackberry Limited
    Inventors: Kuo-Feng Tong, Jeffrey John Paul Dippel, Kevin Paul Timmerman
  • Patent number: 8980387
    Abstract: A method of coating a surface, preparing a doped metal-ion precursor solution for coating, and an article including a component coated by the described method are disclosed. The method of coating includes applying a fluoro-silane doped metal-ion precursor solution on the surface to form a coated surface. The metal-ion precursor solution includes greater than about 0.6 molar percent concentration of a metal-ion precursor in a solvent comprising an alcohol. The method of preparing the doped metal-ion precursor solution includes dissolving a metal-ion precursor in a solvent comprising an alcohol at a temperature greater than about 100° C. and refluxing at a temperature greater than about 150° C. such that the concentration of metal-ion precursor in the solution is greater than 0.6 molar percent of the solution, and adding a fluoro-silane to the metal-ion precursor solution.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: March 17, 2015
    Assignee: General Electric Company
    Inventors: Kevin Paul McEvoy, Ambarish Jayant Kulkarni, James Anthony Ruud
  • Patent number: 8981306
    Abstract: Scintillator arrays and methods of making scintillator arrays are provided. One scintillator array includes a scintillator substrate having a plurality of scintillators spaced apart by gaps within the scintillator substrate and a smoothing layer overlaying a surface of the scintillator substrate within the gaps. The smoothing layer includes an organically modified silicate. The scintillator array also includes an optical reflector layer overlaying a surface of the smoothing layer within the gaps.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 17, 2015
    Assignee: General Electric Company
    Inventors: James Edward Murphy, Kevin Paul McEvoy