Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP?. Further disclosed are formulations to increase the efficacy of the compounds that activate Tie-2 and inhibit HPTP?.

Abstract: A connector is used to connect a gases supply to a user. The user can be fitted with an interface, such as a cannula, while the gases supply can include a conduit. The connector interfaces between the conduit and the interface. The connector has a female assembly and a male assembly that connect together, such as by push fit. The male assembly includes an inner portion sized and configured to mate with a first female connector and an outer portion sized and configured to alternatively mate with a second female connector.

Abstract: Systems, methods, and storage mediums storing methods of natural capital measurement are described. A region of influence for the area whose natural capital is to be measured is determined and segmented into a plurality of segments. A land assessment model, including a system dynamics model and a spatially explicit model, is generated for the region of influence by training one or more machine learning algorithms to classify land use categories for the segments and to determine statistical relationships between state variables and properties of the segment. A flow sequence for simulating a transport of materials between the plurality of segments is executed to update the land assessment model. Health indicators for the natural capital of the area are generated using the updated land assessment model.

Abstract: A respiratory assistance apparatus is configured to provide a heated and humidified glow of gases and has a control system that is configured to detect a fault in the flow path. A flow path is provided for a gases stream through the apparatus from a gas inlet through a blower unit and humidification unit to a gases outlet. A flow rate sensor is provided in the flow path and is configured to sense the flow rate and generate an flow rate signal and/or a motor speed sensor is provided that is configured to sense the motor speed of the blower unit and generate an indicative motor speed signal.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: The present invention provides a breathing assistance apparatus that has a convenient and effective method of cleaning internal conduits inside the apparatus. The breathing assistance apparatus is preferably a gases supply and humidification device. The cleaning method is a method of disinfection that is automated so minimal training is required to disinfect in particular an internal elbow conduit within the device. It is therefore not necessary to dismantle the gases supply and humidification device, therefore, inadvertent damage to the internal parts of the device is avoided. The present invention also provides a method of disinfecting a heated breathing conduit and a patient interface.

Abstract: Systems, methods, and storage mediums storing methods of natural capital measurement and soil organic property determination are described. A land intelligence system for an area whose natural capital is to be assessed using one or more health indicators is initialised. A region of influence for the area is determined and segmented into a plurality of segments. A land assessment model, including a system dynamics model and a spatially explicit model, is initialised for the region of influence. A flow sequence for simulating a transport of materials between the plurality of segments is executed to update the land assessment model. Health indicators for the natural capital of the area are generated using the updated land assessment model. Information on soil organic carbon properties for the region of influence is generated by querying pre-defined statistical relationships for the soil organic carbon properties using measured parameters for the region of influence.

Abstract: A system and method for asset registration and tagging includes determining candidate devices on a network or subnet. Device information is pulled from discovered devices. Device records are stored with device information including device serial number, model number, asset ID and service record information. A QR code is generated and displayed or printed at each discovered device. A device user scans the QR code to supply location information, as well as other user input, which is added to the device information. A device is then registered and an asset tag is printed at the device with instructions to affix it on an exterior for future reference.

Abstract: A school bus stop arm and drive unit therefor are disclosed. The stop an includes a stop sign and a drive unit for moving the stop sign between a retracted position and a deployed position. The drive unit comprises a motor operably coupled to the stop sign, one or more position sensors operable to detect the presence of the stop sign, and a controller for controlling operation of the motor. The controller configured to, monitor one or more operating characteristics of the motor for conditions indicative of an obstruction to movement of the stop sign, monitor the position sensor for a confirmation signal indicative of the presence of the stop sign in the deployed or retracted position, and based on the conditions indicative of an obstruction and the confirmation signal, determine if the stop sign has reached one of the deployed and retracted positions or is being obstructed.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Abstract: The breathing assistance apparatus of the present invention includes a manifold that is provided with or retrofittable to gases supply and humidifying devices. The manifold allows gases from an oxygen concentrator to be combined with the flow through a gases supply and humidifying device, most usually air. The combined output of oxygen and other breathing gases (air) is then humidified. The breathing assistance apparatus and manifold of the present invention provides a safe method to add oxygen to the input air stream of a gases supply and humidifying device and reduces the amount of accumulation of oxygen within the gases supply device, reducing fire risk should sparking occur within the device.

Abstract: A breathing assistance apparatus is configured with features that improve serviceability of the apparatus. The apparatus can include animations to provide instruction regarding correcting easily-identified fault conditions and to provide instruction regarding routine maintenance routines. The apparatus also can be configured with top level control menus that are obscured in a manner to limit manipulation of the top level control elements by unauthorized users.

Abstract: Described is a respiratory therapy system that comprises a respiratory therapy apparatus that is configured to provide a flow of breathable gas at, at least a first pressure and a second pressure to a patient. The respiratory therapy apparatus comprises a flow generator configured to provide the flow of breathable gas, a controller, coupled to a trigger sensor, to control respiratory therapy apparatus operations, a breathing conduit assembly that conveys the breathable gas to a patient via a patient interface, a trigger that produces a signal detectable by the trigger sensor. The controller is configured to control the flow generator to provide the flow of breathable gas at, at least the first pressure or the second pressure based on detection of the signal from the trigger.

Abstract: A breathing assistance apparatus and method of controlling a breathing assistance apparatus is disclosed. Particularly, the breathing assistance apparatus is controlled such that it has a drying cycle to enable drying of the tubing that supplies gases to a user and prevent the harbouring of pathogens within the tube. The drying cycle is preferably operated automatically by internal controllers in the apparatus. However, it may be manually activated by pressing a button on the apparatus. The drying cycle is preferably activated at the end of a user's treatment session.

Abstract: The gases temperature supplied to a patient when the patient is undergoing treatment such as oxygen therapy or positive pressure treatment for conditions such as Obstructive Sleep Apnea (OSA) or Chronic Obstructive Pulmonary Disease (COPD) is often measured for safety and to enable controlling of the humidity delivered to the patient. The invention disclosed is related to measurement of properties, particularly temperature (thermistor), of gases flowing through a heated tube, supplying gases to a patient, which utilises the heating wire within the tube.

Abstract: A breathing assistance system for delivering a stream of heated, humidified gases to a user, comprising a humidifier unit which holds and heats a volume of water, and which in use receives a flow of gases from a gases source via an inlet port, the flow of gases passing through the humidifier and exiting via an exit port, the system further having a temperature sensor which measures the temperature of the gases exiting the humidifier unit, an ambient temperature sensor which measures the temperature of gases before they enter the humidifier unit, and a flow sensor which measures the flow rate of the gases stream, the system also having a controller which receives data from the temperature and flow sensors, and which determines a control output in response, the control output adjusting the power to the humidifier unit to achieve a desired output at the humidifier unit exit port.

Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Formulations for increased solubility are disclosed. Combination therapy with antibodies and PK/PD data are also disclosed.