Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

Abstract: Compounds of formula IA and IB are new 1

Abstract: A removable, variable-diameter vascular filter system comprising a guidewire and a filter which can be used to capture embolic particulates during medical procedures, while allowing for continuous perfusion of blood. The removable, variable-diameter vascular filter system allows the operator to vary the diameter of the filter, so that a single device can be used to capture embolic particulates in vessels with different lumenal diameters.

Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

Abstract: A self-expanding stent delivery apparatus having a reinforced sheath for the safe, effective and accurate deployment of self-expanding stents. The sheath is formed from an inner polymeric layer, an outer polymeric layer and a reinforcement layer sandwiched therebetween. The reinforcement layer comprises flat metallic wire to provide the requisite radial and axial strength. In addition, flat wire reduces the profile of the device.

Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

Abstract: The invention relates to an elite event glufosinate tolerant rice plant transformed with a bar gene, such as a 35S-bar gene, where the gene is inserted into the location defined by SEQ ID [No] NO: 9 within the rice genome, and methods of making and using the glufosinate tolerant rice plant.

Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

Abstract: A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

Abstract: A recumbent cycling apparatus is provided that includes a frame structure, wheels rotatably attached to supporting the frame structure, and a central frame element configured to absorb and reduce the forces transmitted through the frame structure to a user. The frame structure has a front frame section and a back frame section that are substantially parallel to the ground. The central frame element is a curved elongated member composed of chromoly steel that is attached to the front frame section and the back frame section and extends therebetween. The central frame element is configured to allow the front frame section and the back frame section to move substantially independently in response forces exerted on the wheels. The central frame element is disposed in a substantially vertical plane above the back frame section and the front frame section and is substantially perpendicular thereto. A pair of recumbent seats are mounted on the back frame section in a side-by-side relationship.

Abstract: A dilation catheter suitable for use in medical procedures is provided which includes a balloon disposed on an elongated flexible tube. The tube is capable of passing fluid between the balloon and the tube for varying the balloon between a collapsed and expanded condition. The catheter includes a brace fitted over the balloon for restricting expansion of a selected portion of the balloon for forming a perfusion channel that allows fluid to be perfused past the balloon when it is expanded in a body vessel. A medical procedure for dilation under perfusion conditions is also provided.

Abstract: Methods of treatment and prevention of diseases associated with release of neutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

Abstract: A balloon catheter having concentric, elongate lumen and guide tubes defining a lumen therebetween. An annular balloon has its proximal end secured to the lumen tube and its distal end secured to the guide tube. Relative axial movement of the tubes adjusts the balloon between retracted and extended positions. Processes for using the balloon catheter are also disclosed including performing angioplastic procedures on a plurality of stenoses of differing longitudinal extents during a single catheterization procedure, implanting self expanding stents in blood vessels treating occluded blood vessels and apply medications to diseased blood vessels.

Abstract: In accordance with the present invention there is provided a delivery apparatus for a self-expanding stent. The apparatus includes an outer sheath, which is an elongated tubular member having distal and proximal ends. The outer sheath is made from an outer polymeric layer, an inner polymeric layer, and a braided reinforcing layer between the inner and outer layers. The reinforcing layer is more rigid than the inner and outer layers. The apparatus further includes an inner shaft located coaxially within the outer sheath. The shaft has a distal end, extending distal to the distal end of the sheath, and a proximal end, extending proximal to the proximal end of the sheath. The shaft further includes a stop attached thereto. The stop is proximal to the distal end of the sheath. Lastly, the apparatus includes a self-expanding stent located within the sheath. The stent makes frictional contact with the inner layer of the sheath.

Abstract: A catheter assembly is provided for delivering a diagnostic fluid to a diagnostic site within the vascular system of a patient comprising an elongated central tube that can be routed into and through a vascular system of a patient, the tube including a tube proximal end and a tube distal end, a flexible sleeve defining a space between the interior surface of the sleeve and an exterior surface of the central tube, the sleeve comprising a sleeve proximal end sealably connected to the exterior circumference of the central tube. The sleeve extends along a length of the central tube from the sleeve proximal end to a sleeve distal end, the central tube defining one or more openings that extend through a wall of the central tube so that the interior of the central tube is in fluid communication with the interior of the sleeve.

Abstract: A check valve for preventing backflow in a conduit. The check valve includes a check valve mechanism having a valve seat defining an opening for fluid flow, a seal retainer positioned downstream of the valve seat and configured to seal the opening and a linkage between the valve seat and seal retainer. The linkage permits guided axial displacement between the valve seat and the seal retainer. The linkage also provides a retention force urging the seal retainer into engagement with the valve seat and creating a fluid seal therebetween when a downstream flow in the opening is insufficient to overcome the retention force provided by the linkage.

Abstract: Methods of treatment and prevention of diseases associated with release of eutrophil elastase and IL-8 by administration of TFPI, and analogs of TFPI are disclosed. Methods of determining efficacy of treatment with TFPI, patient's responsiveness to treatment with TFPI and the ultimate determination of patient prognosis are also disclosed.

Abstract: Coiled-coil molecular recognition is a primary mode of subunit assembly in a large variety of naturally occurring macromolecular complexes. Here we report the use of coiled-coil mediated solution assembly to form a stable, heteromeric complex of Interleukin-2 receptor ectodomains that binds IL-2 cooperatively and with an affinity approaching the comparable cell surface complex. Cross-linking of homomeric or heteromeric receptor subunits is the common signal transmission mechanism employed by hematopoietin receptors. Individual receptor ectodomains, however, often do not bind ligand with measurable affinity. The claimed invention is useful for coiled-coil mediated assembly of receptor complexes for solution analysis. It also shows that hetero-oligomeric complexes can be formed using a leucine zipper domain.

Abstract: A catheter assembly is provided for delivering a diagnostic fluid to a diagnostic site within the vascular system of a patient comprising an elongated central tube that can be routed into and through a vascular system of a patient, the tube including a tube proximal end and a tube distal end, a flexible sleeve defining a space between the interior surface of the sleeve and an exterior surface of the central tube, the sleeve comprising a sleeve proximal end sealably connected to the exterior circumference of the central tube. The sleeve extends along a length of the central tube from the sleeve proximal end to a sleeve distal end, the central tube defining one or more openings that extend through a wall of the central tube so that the interior of the central tube is in fluid communication with the interior of the sleeve.