Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

Abstract: Embodiments relate generally to systems and methods for updating the location information for a gas detector device. A gas detector device may comprise a wireless receiver operable to receive information from one or more wireless beacons. In some cases, the wireless beacons may comprise location information. When the gas detector device receives a wireless beacon, the location information stored on the gas detector device may be updated accordingly. In some cases, the subsequent readings of the gas detector device may be associated with the updated location information. In some cases, the wireless beacons may be located at critical areas within a facility, such as entrances or exits to locations.

Abstract: Embodiments relate generally to methods and systems for user association with a gas detector using passive NFC tags. Applicants propose a gas detector with a near-field communication (NFC) reader built into the gas detector, thereby allowing the user to scan their employee identification (ID) badge or a specialized individualized NFC tag. In some embodiments, an NFC tag may be attached to an employee ID badge. The gas detector may communicate via NFC with the badge and/or tag, and may recognize the badge and/or tag as associated with a specific user. When the user starts their shift, the gas detector with an NFC reader can scan the tag and associate the user with the detector and store the information in a log for archival purposes. This process can be completed by the user, and does not require connecting the gas detector to a computer to provide the association.

Abstract: Embodiments relate generally to systems and methods for updating the location information for a gas detector device. A gas detector device may comprise a wireless scanner operable to receive information from one or more passive tags. In some cases, the passive tags may comprise location information. When the gas detector scans a passive tag, the location information stored on the gas detector may be updated accordingly. In some cases, the subsequent readings of the gas detector may be associated with the updated location information. In some cases, the passive tags may be located at critical areas within a facility, such as entrances or exits to locations.

Abstract: Embodiments relate generally to methods and systems for configuring a gas detector using near-field communication (NFC). A gas detector may be equipped with an NFC reader that will allow the gas detector to scan and read NFC tags. Compatible NFC tags may be acquired and programmed with the configuration settings information. The NFC tag may then be attached to a poster with instructions that show where to place the detector in order to confirm their device's configuration. When the detector is placed in the appropriate location near the tag on the poster, the detector may receive information from the NFC tag, implement the configuration settings, and possibly display a confirmation message to the user. The NFC tag may also be attached to a card carried by a monitor for that work area.

Abstract: In an illustrative embodiment, systems and methods for determining exposure include detecting, based on received data from external entities, an occurrence of a catastrophic event. Responsive to detecting the occurrence, a first matrix is generated indicating features of one or more properties within a vicinity of the catastrophic event, and a second matrix is generated representing characteristics of the catastrophic event. Using the first matrix and the second matrix, a convolution calculation matrix is calculated indicating amounts of correspondence between the first matrix and the second matrix. In real time, in response to detecting the occurrence of the catastrophic event, present risk exposure information to at least one remote computing system associated with at least one property of the plurality of properties, where the risk exposure data relates to the amount of correspondence between the first matrix and the second matrix in reference to the at least one property.

Abstract: Embodiments relate generally to methods and systems for configuring a gas detector using near-field communication (NFC). A gas detector may be equipped with an NFC reader that will allow the gas detector to scan and read NFC tags. Compatible NFC tags may be acquired and programmed with the configuration settings information. The NFC tag may then be attached to a poster with instructions that show where to place the detector in order to confirm their device's configuration. When the detector is placed in the appropriate location near the tag on the poster, the detector may receive information from the NFC tag, implement the configuration settings, and possibly display a confirmation message to the user. The NFC tag may also be attached to a card carried by a monitor for that work area.

Abstract: Embodiments relate generally to systems and methods for indicating when a gas detector is out of compliance. A Bluetooth Low Energy (BLE) enabled wireless gas-detector may allow for an advertisement packet to be transmitted from the gas detector. This advertisement packet may contain information about the gas detector to allow remote auditing from any BLE enabled remote listening device. This auditor device may be in the form of a mobile device, such as a cell phone or tablet, a fixed location auditor device, or any other BLE enabled device.

Abstract: Embodiments relate generally to methods and systems for user association with a gas detector using passive NFC tags. Applicants propose a gas detector with a near-field communication (NFC) reader built into the gas detector, thereby allowing the user to scan their employee identification (ID) badge or a specialized individualized NFC tag. In some embodiments, an NFC tag may be attached to an employee ID badge. The gas detector may communicate via NFC with the badge and/or tag, and may recognize the badge and/or tag as associated with a specific user. When the user starts their shift, the gas detector with an NFC reader can scan the tag and associate the user with the detector and store the information in a log for archival purposes. This process can be completed by the user, and does not require connecting the gas detector to a computer to provide the association.

Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

Abstract: A device having a winch spool, a torque sensor that measures torque of the winch spool, a first angle sensor that detects a first angle of a winch line relative to a central axis of the winch spool, and a second angle sensor that detects a second angle of the winch line coming from a coil of line on the spool relative to a surface of the coil of line is disclosed.

Abstract: Audio/video recorders are presented for recording audio and video of various types of proceedings, including court proceedings. In some examples, audio/video recorders may obtain case information associated with a case identifier from a case management database, and associate at least some of the case information with one or more audio channel inputs of the audio interface. In some examples, audio/video recorders may associate a speaker with an audio channel input of the audio interface, determine that an amplitude of an audio signal received at the audio channel input is above a threshold, determine a time when the amplitude of the audio signal at the audio channel was determined to be above the threshold, and generate metadata as a timeline indicating that the first speaker began speaking at the first time.

Abstract: A wire frame visor includes a generally U-shaped wire frame having inwardly extending spaced-apart opposed ends. An envelope of sun-blocking material is fastened over the generally rectangular wire frame. A mounting structure pivotally receives the opposed ends of the wire frame and is adapted to be secured to a location in a vehicle for use of the visor. In a preferred embodiment of the invention, the mounting structure includes at least one adjustable torque clip which receives an inwardly projecting end of the wire frame to control the pivotal motion of the visor. In one embodiment the torque clip includes a loop which surrounds the end of the wire frame and an adjustment screw for tightening the loop around the wire end. Straps can be employed to attach the mounting structure to a side tubular member of a vehicle when so equipped.

Abstract: An embodiment of an energy absorbing container may include a shell formed of a plastic material, one or more energy absorbing components for absorbing energy resulting from impact loads, and an opening mechanism for opening the container and allowing the placement or removal of a bottle therefrom. The energy absorbing components securing a bottle stored within the container to may inhibit or prevent movement of the bottle within the container.

Abstract: Systems and methods of the present technology provide the capability to determine risk exposure of points of interest (e.g., insured locations) based on the occurrence of an event (e.g., a catastrophic event). The systems and methods use two-dimensional convolution and FFT processing to provide quick determinations.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: Methods are disclosed for classifying different parts of a sample into respective classes based on an image stack that includes one or more images.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: An apparatus and method that can measure flux density in-situ under high vacuum conditions includes a means for confining a collection of identical, elemental sensor particles to a volume of space by initial cooling by laser or another method, then confinement in a sensor volume using externally applied magnetic and/or optical fields.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.