Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: A computer-implemented method for detecting and predicting anomalies in an energy management system is presented. The method includes detecting, in real-time, a first set of outliers for a plurality of energy devices under operation, predicting a second set of outliers for running the plurality of energy devices, analyzing historical energy data of the plurality of energy devices to extract a third set of outliers, receiving feedback, in real-time, from a user regarding each of the first, second, and third sets of outliers, and training the energy management system with the real-time feedback received from the user to automatically optimize a threshold of error detection.

Abstract: A method of aggregated virtual power plant (VPP) control includes receiving control variable values. The control variables are received for control variables related to energy production and loads of devices electrically coupled to an electrical grid and communicatively coupled to the VPP controller server. The method includes inputting the control variable values into an objective algorithm. The method may include executing the objective algorithm. Executing the objective algorithm includes adjusting energy loads and energy production of prosumers, adjusting an energy amount supplied from a supply side for multiple time intervals, and adjusting curtailment of the energy loads in the prosumers based thereon. The method includes generating a VPP DR event schedule and communicating it to VPP client servers. The VPP DR event schedule includes control signals that are configured to affect an operating condition of the devices that are controlled by the VPP client servers.

Abstract: A forged crankshaft manufacturing apparatus processes a forged blank with no flash. The forged blank includes at least one rough crank arm having an excess portion protruding from an outer periphery of a side portion thereof. The manufacturing apparatus includes a first die and a second die paired with each other, a retaining device, and a moving device. The first die and the second die bend or crash the excess portion. The retaining device retains at least one of the rough journals or at least one of the rough pins such that a rough pin decentering direction is perpendicular to a reducing direction in which the first die and the second die apply force for reduction. The moving device supports the retaining device such that the retaining device is movable in the reducing direction.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: An in-vehicle information apparatus includes a main unit having a display device, and a navigation unit providing a navigation function to the main unit. The navigation unit includes a navigation processing unit a sub unit providing an addition function to the navigation unit, and a navigation unit screen generating unit which generates a navigation unit screen for displaying information concerning a function which the navigation unit provides. The main unit includes an operation unit which receives an input for selecting a function from a user, a main unit screen generating unit which generates a main unit screen for displaying information concerning a function which the main unit provides, and a video selector which selects one of the navigation unit screen and the main unit screen.

Abstract: A servomotor control apparatus according to the present invention is a control apparatus for controlling a machine having one or a plurality of movable portions each driven by a servomotor. In the servomotor control apparatus, while an electromagnetic brake is operated, an actual position obtained by a position detector is periodically monitored. The actual position is compared with the actual position at the time of actuating the electromagnetic brake. When the actual positions are different by a predetermined value or more, any of the issue of a motor torque to maintain the position, the actuation of a regenerative brake, or a control means for continuing a control to maintain the position without operating the electromagnetic brake, even if the servomotor stops for a certain period of time during playback operation, is performed.

Abstract: A computer-implemented method is provided for managing a plurality of micro grids in an energy system. The method includes collecting and maintaining, in a central database, configuration information and state information for the plurality of micro grids, by a processor-based dynamic operation engine. The method further includes identifying failures in any of the plurality of micro grids and generating updated configuration information and updated state information relating to the failures, based on data analytics and diagnostic polling applied to the configuration information and the state information, by a processor-based micro grid diagnostic engine.

Abstract: A method of aggregated virtual power plant (VPP) control includes receiving control variable values. The control variables are received for control variables related to energy production and loads of devices electrically coupled to an electrical grid and communicatively coupled to the VPP controller server. The method includes inputting the control variable values into an objective algorithm. The method may include executing the objective algorithm. Executing the objective algorithm includes adjusting energy loads and energy production of prosumers, adjusting an energy amount supplied from a supply side for multiple time intervals, and adjusting curtailment of the energy loads in the prosumers based thereon. The method includes generating a VPP DR event schedule and communicating it to VPP client servers. The VPP DR event schedule includes control signals that are configured to affect an operating condition of the devices that are controlled by the VPP client servers.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: A servomotor control apparatus according to the present invention is a control apparatus for controlling a machine having one or a plurality of movable portions each driven by a servomotor. In the servomotor control apparatus, while an electromagnetic brake is operated, an actual position obtained by a position detector is periodically monitored. The actual position is compared with the actual position at the time of actuating the electromagnetic brake. When the actual positions are different by a predetermined value or more, any of the issue of a motor torque to maintain the position, the actuation of a regenerative brake, or a control means for continuing a control to maintain the position without operating the electromagnetic brake, even if the servomotor stops for a certain period of time during playback operation, is performed.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: An in-vehicle information apparatus according to the invention includes a main unit having a display device, and a navigation unit providing a navigation function to the main unit. The navigation unit includes a navigation processing unit which executes a process concerning the navigation function, a sub unit providing an addition function to the navigation unit, and a navigation unit screen generating unit which generates a navigation unit screen for displaying information concerning a function which the navigation unit provides. The main unit includes an operation unit which receives an input for selecting a function from a user, a main unit screen generating unit which generates a main unit screen for displaying information concerning a function which the main unit provides, and a video selector which selects one of the navigation unit screen and the main unit screen and provides the selected one to the display device.

Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.

Abstract: A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.

Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.