Abstract: In order to enhance resolving power and making the fabrication of an optical system easy, the image pickup device is of an arrangement that a color-separating optical means is disposed between an objective lens and a solid-state image sensor, and those images by the respective color lights which are focused at mutually displaced positions on the solid-state image sensor are integrated into one unified image by a signal processing circuitry to thereby collect also the image-informations corresponding to those areas lying between the picture elements. The color-separating optical means may be formed by either one of a color dispersion prism, a dichroic mirror, a diffraction grating, a glass block made of a medium of heterogeneous material and a light-divider containing liquid crystal.

Abstract: An image pickup apparatus comprises an image pickup unit including a solid-state image sensor and a drive voltage generator circuit disposed adjacent to the image sensor and having a drive voltage adjusting device for adjusting a drive voltage required to properly drive the image sensor, a signal processor unit for applying various voltages and signals to the image pickup unit and a signal cable system connecting the image pickup unit to the signal processor unit, whereby proper voltages can be applied to the image sensor with a reduced number of signal cables and a reduced size of the apparatus.

Abstract: This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,R.sup.3 is lower alkyl,R.sup.4 is acyl, cyano, carboxy, hydroxy(lower)-alkyl, mercapto, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, 5-membered unsaturated heterocyclic group which may have amino, lower alkanoylamino, lower alkylthio or lower alkylsulfonyl, phenylthio which may have nitro or amino, lower alkanoyl(lower)alkenyl or a group of the formula: ##STR2## wherein R.sup.6 is hydrogen, amino or lower alkyl andR.sup.7 is hydroxy, lower alkoxy, carboxy(lower)alkoxy, lower alkoxycarbonyl(lower)alkoxy, ureido or thioureido, andR.sup.5 is hydrogen, halogen, lower alkyl or lower alkanoyl, and pharmaceutically acceptable salts thereof.

Abstract: A video endoscope apparatus including an insertion section insertable into a cavity of a patient body under inspection a solid state image sensor arranged at a distal end of the insertion section for converting an optical image of the cavity into an electric signal a video processor unit including a driving circuit for generating a driving signal including vertical and horizontal driving pulses and a reset pulse for the solid state image sensor, and a video processing circuit for processing the electric signal supplied from the solid state image sensor to derive an image signal to be displayed on a monitor is provided with circuitry for compensating for image signal distortion caused by aberrations in the driving and reset pulses received at the insertion section due to differing signal cable lengths between the insertion section and the video processing unit.

Abstract: A composite video signal is supplied to chrominance and luminance signal separators. A chrominance signal is compared by a phase comparator with an average phase signal, and a difference between them is supplied to a control terminal of a phase modulator. The chrominance signal is input to the phase modulator. The phase averaging circuit, phase comparator, and phase modulator together constitute a hue emphasizing circuit. An output from the hue emphasizing circuit (output from phase modulator) is supplied to a mixer via a gain control amplifier (GCA). The chrominance signal is input to a level detector, where it is envelope-detected. An output from the level detector is supplied to a gain control terminal of the GCA. An output from the GCA emphasizing circuit (output from GCA) is a hue- and saturation-emphasized chrominance signal, and is supplied to the first input terminal of the mixer. A luminance signal is put to a phase shifter via a mixer.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.2 is cyclo(lower)alkyl or lower alkynyl having 2 to 6 carbon atoms, andR.sup.6 is amino or protected amino, or the reactive derivative at the carboxy group, are disclosed as intermediates for the preparation of cephem and cepham compounds having antimicrobial activity.

Abstract: A composite video signal is supplied to chrominance and luminance signal separators. A chrominance signal is compared by a phase comparator with an average phase signal, and a difference between them is supplied to a control terminal of a phase modulator. The chrominance signal is input to the phase modulator. The phase averaging circuit, phase comparator, and phase modulator together constitute a hue emphasizing circuit. An output from the hue emphasizing circuit (output from phase modulator) is supplied to a mixer via a gain control amplifier (GCA). The chrominance signal is input to a level detector, where it is envelope-detected. An output from the level detector is supplied to a gain control terminal of the GCA. An output from the GCA emphasizing circuit (output from GCA ) is a hue- and saturation-emphasized chrominance signal, and is supplied to the first input terminal of the mixer. A luminance signal is input to a phase shifter via a mixer.

Abstract: An imaging apparatus for use in an electronic endoscope or the like is provided with a mechanically driven light-shielding plate, wherein imaging is effected by using a solid-state imaging device starting from a time when an amount of light shielded by this light-shielding plate becomes minimal, or imaging is effected repeatedly during a short exposure time within a transient period during which the amount of light shielded becomes minimal, and when an signal level of each image reaches a reference level, that signal is stored in a memory.

Abstract: The present invention relates to N-containing fused heterocyclic compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, halogen, aryl, lower alkyl, halo (lower) alkyl or nitro,R.sub.3 is lower alkylene,R.sub.4 and R.sub.5 are each lower alkylene,X is CH or N,Y is S, O, NH, C.dbd.N--OH or CO,Z is O or NH, andA is hydrogen, nitroso, amidino, a group of ##STR2## wherein R.sub.6 and R.sub.7 are each hydrogen, lower alkyl, acyl, or lower alkaneimidoyl which may be substituted with esterified carboxy, or a group of the formula:--N.dbd.R.sub.8,wherein R.sub.8 is lower alkylidene which may be substituted with aryl optionally substituted with suitable substituent(s).The compounds are useful for treatment of thrombosis, inflammation, or allergic disease.

Abstract: The invention relates to novel cephem compounds, of high antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl substituted with 1 to 3 halogen atoms,R.sup.3 is thiadiazolylthiomethyl which may be substituted with lower alkyl, or tetrazolylthiomethyl which may be substituted with lower alkyl or lower alkenyl, andR.sup.4 is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof.

Abstract: Compounds useful as inhibitors of the enzyme elastase are of the following general formula: ##STR1## wherein Z is selected from the group consisting of R"O--Suc-- where R" is lower alkyl of 1 to 3 carbon atoms and CF.sub.3 CO--; X is oxygen or sulfur; R' is selected from the group consisting of straight or secondary branch-chained alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 3 carbon atoms, alkynyl of 2 to 4 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, and benzyl, and R is selected from the group consisting of susbstituted or unsubstituted phenyl wherein the substituents are selected from the group consisting of nitro, and pentafluoro; benzyl, CH.sub.2 CF.sub.2 CF.sub.2 CF.sub.3, 1-lower alkyl tetrazolyl, 1-phenyltetrazolyl, 2-thioxo-3-thiazolidinyl-, pyridyl and benzothiazolyl, provided that when R is paranitrophenyl, R' is other than tertiary-butyl, benzyl or cyclohexyl, and when X is sulfur, R is other than benzyl.

Abstract: 7-substituted 3-cephem or cepham compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and A is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: Thiazole intermediates for cephalosporins have been prepared.

Abstract: The invention relates to novel intermediates for preparing novel cephem compounds of high antimicrobial activity, the intermediates being of the formula: ##STR1## wherein A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, protected carboxy, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, phenyl(lower)alkyl or aryl; andR.sup.7a is hydrogen or a mercapto-protective group, or a salt thereof.

Abstract: 7-substituted 3-cephem or cepham compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and A is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: The invention relates to novel cephem compounds, of antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is lower alkoxy, andR.sup.4 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: This invention relates to novel compounds useful as intermediates in the preparation of cephalosporin compounds of antibacterial activity, having the formula ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino, andR.sup.2 is hydrogen or a saturated or unsaturated aliphatic hydrocarbon residue,a derivative at the carboxy group thereof and salt thereof.

Abstract: There are disclosed compounds of the formula: ##STR1## in which R is lower alkoxycarbonyloxy(lower)alkyl or 1-propionyloxyethyl, or a salt thereof, pharmaceutical compositions containing the same and their use to treat infectious diseases.

Abstract: A compound of the formula: ##STR1## in which R.sup.1 is thiadiazolyl,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is hydrogen, halogen or lower alkenyl, andR.sup.4 is carboxy or a protected carboxy group, and pharmaceutically acceptable salts thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity comprising the syn-isomers of 7-substituted-3-cephem-4-carboxylic acid esters of the formula: ##STR1## wherein R is lower alkanoyloxy (C.sub.2 -C.sub.6)alkyl, isobutyryloxymethyl, 2-ethylbutyryloxymethyl or 3,3-dimethylbutyryloxymethyl,or salts thereof.