Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy,R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, their preparation and their pharmaceutical uses.

Abstract: This invention relates particularly to a syn compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy, R.sup.3 and R.sup.4 are each lower alkyl, R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing the same and method of using the same for treating infectious disease.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is carboxy or a protected carboxy group;A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; andR.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.

Abstract: The invention relates particularly to syn compounds of the formula ##STR1## wherein R.sup.2 is C.sub.1 -C.sub.8 alkyl, R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: 7-Substituted 3-cephem or cephem compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and a is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: The invention relates to new cephem compounds, of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is halogen or lower alkoxy, andR.sup.4 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is an aliphatic hydrocarbon residue substituted with halogen, carboxy or esterified carboxy,R.sup.4 is halogen or a group of the formula:--O--R.sup.7, in which R.sup.7 is lower alkyl,R.sup.5 is carboxy or functionally modified carboxy andR.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making the compounds, pharmaceutical compositions containing them and their use to treat infectious diseases.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.1 is thiadiazolyl,R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy andR.sup.5 is carboxy or functionally modified carboxy, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon which may be substituted with halogen, carboxy or pharmaceutically acceptable esterified carboxy,R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy,R.sup.6 is amino or protected amino andR.sup.7 is lower alkanesulfonyl or arenesulfonyl and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, to processes for preparation of said compounds, and to pharmaceutical compositions containing said compounds, the cephem compounds being of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl of from one to six carbon atoms substituted with aryl hydrocarbon of from 6 to 10 carbon atoms or substituted aryl hydrocarbon with at least one halogen, hydroxy, amino (lower) alkyl, amido (lower) alkyl, or lower alkyl substituent,R.sup.3 is carboxy or protected carboxy, andR.sup.4 is hydrogen,and its pharmaceutically acceptable salt.

Abstract: The invention relates to new cephalosporin compounds of high antimicrobial activity, the compounds being of the formula: ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen, imino or lower-alkanoyl-substituted imino, R.sup.2 is hydrogen, lower alkyl or lower alkenyl,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, carbamoyloxymethyl or lower alkanoyloxymethyl, andR.sup.5 is carboxy or its ester, and a non-toxic, pharmaceutically acceptable salt thereof.

Abstract: The invention relates to new thiadiazolyl or thiazolyl-substituted cephem and cepham compounds, the pharmaceutically acceptable salts and bioprecursors thereof, of antimicrobial activity, processes for preparation thereof, intermediates for preparing the new compounds and to pharmaceutical compositions comprising the new compounds, and methods of using the compositions for treatment of infectious diseases.

Abstract: This invention relates to new cephem compounds. More particularly, it relates to new 7-substituted-3-cephem-4-carboxylic acid, its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof, which have antimicrobial activities, and processes for preparation thereof, to intermediate for preparing the same and processes for preparation thereof, and to pharmaceutical composition comprising the same and methods of using the same prophylactically and therapeutically for treatment of infectious diseases in human beings and animals.The cephem compounds of this invention include the compound represented by the formula (I): ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.

Abstract: Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino,M is sulfur or oxygen,R.sup.2 is hydrogen, or a saturated or unsaturated aliphatic hydrocarbon residue,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, acyloxymethyl or heterocyclic-thiomethyl which may be substituted with lower alkyl, andR.sup.5 is carboxy or its derivative, and nontoxic, pharmaceutically salt thereof.