Patents by Inventor Klaus Ditrich
Klaus Ditrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11866443Abstract: The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.Type: GrantFiled: May 9, 2018Date of Patent: January 9, 2024Assignee: BASF AGRO B.V.Inventors: Klaus Ditrich, Michael Rack, Stefan Benson, Roland Goetz, Helmut Kraus
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Patent number: 11639358Abstract: The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.Type: GrantFiled: May 9, 2018Date of Patent: May 2, 2023Assignee: BASF AGRO B.V.Inventors: Klaus Ditrich, Michael Rack, Stefan Benson, Roland Goetz, Helmut Kraus
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Publication number: 20220033411Abstract: The present invention relates to a process for preparing optically active 1,4-cineole derivatives by enzymatic resolution and enantiomerically pure optically active 1,4-cineole derivatives of purity greater than 99.9% that have been prepared by this process. The present invention further relates to a process for preparing 7-oxabicyclo[2.2.1]heptane derivatives from the enantiomerically pure optically active 1,4-cineole derivatives.Type: ApplicationFiled: May 9, 2018Publication date: February 3, 2022Inventors: Klaus Ditrich, Michael Rack, Stefan Benson, Roland Goetz, Helmut Kraus
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Patent number: 11098075Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose, the 2?-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(?O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.Type: GrantFiled: September 11, 2015Date of Patent: August 24, 2021Assignee: BASF SEInventors: Michael Puhl, Klaus Ditrich, Andreas Keller, Pepa Dimitrova, Melanie Weingarten, Wolfgang Siegel
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Publication number: 20200148697Abstract: The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.Type: ApplicationFiled: May 9, 2018Publication date: May 14, 2020Inventors: Klaus DITRICH, Michael RACK, Stefan BENSON, Roland GOETZ, Helmut KRAUS
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Publication number: 20180230176Abstract: The present invention relates to a method for preparing 2?-O-fucosyllactose, the 2?-O-fucosyllactose obtainable by this method and the use thereof. The method comprises reacting the persilylated, protected fucose derivatives of the formula (I) below, with at least one tri(C1-C6-alkyl)silyl iodide and subsequently reacting the product thus obtained with the compound of the general formula (II), in the presence of a base. In the formulae (I) and (II), the variables are each defined as follows: RSi are the same or different and are a residue of the formula SiRaRbRc; R1 is a C(?O)—R11 residue or an SiR12R13R14 residue, R2 are the same or different and are C1-C8-alkyl or together form a linear C3-C6-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents; R3 are the same or different and are C1-C8-alkyl or together form a linear C1-C4-alkanediyl, which is unsubstituted or has 1 to 6 methyl groups as substituents.Type: ApplicationFiled: September 11, 2015Publication date: August 16, 2018Inventors: MICHAEL PUHL, Klaus DITRICH, Andreas KELLER, Pepa DIMITROVA, Melanie WEINGARTEN, Wolfgang SIEGEL
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Patent number: 9834798Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.Type: GrantFiled: September 3, 2013Date of Patent: December 5, 2017Assignee: BASF SEInventors: Andrea Piatesi, Kai-Uwe Baldenius, Klaus Ditrich, Alois Kindler, Marta Zajaczkowski-Fischer, Ralf Boehling, Alwin Rehfinger
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Patent number: 9828617Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.Type: GrantFiled: August 13, 2013Date of Patent: November 28, 2017Assignees: BASF SE, Evolva SAInventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
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Patent number: 9796992Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.Type: GrantFiled: November 19, 2013Date of Patent: October 24, 2017Assignee: BASF SEInventors: Oskar Zelder, Birgit Hoff, Hartwig Schröder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingruber, Jakob Weber
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Publication number: 20170145451Abstract: The present invention relates to a novel biocatalytic method for the production of primary and secondary amines, comprising coupled enzymatic oxidation and reduction processes simultaneously regenerating the required cofactor; making use of two enzymes—i.e. an alcohol dehydrogenase and an amine dehydrogenase—operating simultaneously in a one pot process (i.e. biocatalytic cascade). Furthermore, the overall process is redox neutral, since the hydride generated from the first oxidative step is internally recycled in the second reductive step. The invention also relates to recombinant expression systems and microorganisms procuring the required enzyme activities; and bioreactors for performing such methods.Type: ApplicationFiled: July 2, 2015Publication date: May 25, 2017Inventors: Kai-Uwe Baldenius, Michael Breuer, Klaus Ditrich, Vaidotas Navickas, Francesco Mutti, Tanja Knaus, Nicholas Turner
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Patent number: 9631212Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.Type: GrantFiled: November 13, 2013Date of Patent: April 25, 2017Assignee: BASF SEInventors: Oskar Zelder, Birgit Hoff, Hartwig Schroeder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingrubber, Jakob Weber
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Publication number: 20150275248Abstract: The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.Type: ApplicationFiled: November 13, 2013Publication date: October 1, 2015Inventors: Oskar Zelder, Birgit Hoff, Hartwig Schroeder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingrubber, Jakob Weber
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Publication number: 20150259713Abstract: A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid.Type: ApplicationFiled: September 3, 2013Publication date: September 17, 2015Applicant: BASF SEInventors: Andrea Piatesi, Kai-Uwe Baldenius, Klaus Ditrich, Alois Kindler, Marta Zajaczkowski-Fischer, Ralf Boehling, Alwin Rehfinger
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Patent number: 9115052Abstract: The present invention relates to a process for separating an enantiomer mixture of (R)- and (S)-3-amino-1-butanol optionally protected on the oxygen atom, and to a process for preparing essentially enantiomerically pure (R)-3-amino-1-butanol which optionally bears a protecting group on the oxygen atom.Type: GrantFiled: January 15, 2010Date of Patent: August 25, 2015Assignee: BASF SEInventors: Klaus Ditrich, Michael Bartsch, Harald Winsel
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Patent number: 9096841Abstract: The present invention relates to a process for the biocatalytic, enantioselective production of a ?-amino acid precursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a ?-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a ?-amino acid precursor or a ?-amino acid, and a method for obtaining said hydantoinase.Type: GrantFiled: September 15, 2010Date of Patent: August 4, 2015Assignee: BASF SEInventors: Nina Schneider, Bernhard Hauer, Klaus Ditrich, Maeve O'Neil, Nick Turner
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Publication number: 20150211036Abstract: Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.Type: ApplicationFiled: August 13, 2013Publication date: July 30, 2015Applicants: BASF SE, Evolva SAInventors: Michael Naesby, Christophe Folly, Curt Aimé Friis Nielsen, Anaelle Hatsch, Markus Schwab, Oskar Zelder, Stefan Haefner, Hartwig Schroeder, Birgit Hoff, Andrea Molt, Klaus Ditrich, Michael Breuer, Holger Hartmann, Karsten Koerber
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Publication number: 20140141440Abstract: The invention pertains to/the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.Type: ApplicationFiled: November 19, 2013Publication date: May 22, 2014Applicant: BASF SEInventors: Oskar Zelder, Birgit Hoff, Hartwig Schröder, Andrea Molt, Holger Hartmann, Klaus Ditrich, Michael Breuer, Rüdiger Reingruber, Jakob Weber
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Patent number: 8709751Abstract: The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.Type: GrantFiled: November 23, 2011Date of Patent: April 29, 2014Assignee: BASF SEInventors: Melanie Bonnekessel, Klaus Ditrich, Jürgen Däuwel, Achim Sorg, Wolfgang Ladner, Bryan Cooper, Rene Backes
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Patent number: 8344182Abstract: The invention relates to a process for the preparation of (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent work-up.Type: GrantFiled: December 10, 2008Date of Patent: January 1, 2013Assignee: BASF SEInventors: Olaf Kutzki, Klaus Ditrich, Michael Bartsch
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Publication number: 20120270280Abstract: The present invention relates to a process for the biocatalytic, enantioselective production of a ?-amino acid pre-cursor from an optionally substituted dihydrouracil using a hydantoinase and/or a dihydropyrimidinase, a process for producing a ?-amino acid from said precursor, a hydantoinase and its use in said process for the biocatalytic production of a ?-amino acid pre-cursor or a ?-amino acid, and a method for obtaining said hydantoinase.Type: ApplicationFiled: September 15, 2010Publication date: October 25, 2012Applicant: BASF SEInventors: Nina Schneider, Bernhard Hauer, Klaus Ditrich, Maeve O'Neil, Nick Turner