Abstract: The invention relates to new amino acid derivatives of general formula ##STR1## wherein R, U, V, Y, n, m and R.sup.1 to R.sup.3 are defined as in claim 1, their tautomers, diastereomers, enantiomers, mixtures thereof and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly selective NPY-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.

Abstract: The invention relates to new amino acid derivatives of general formula ##STR1## wherein R, U, V, Y, n, m and R.sup.1 to R.sup.3 are defined as in claim 1, their tautomers, diastereomers, enantiomers, mixtures thereof and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly selective NPY-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.

Abstract: Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R,S)-N.sup.2 -(diphenylacetyl)-N-?(4-hydroxyphenyl)methyl!-N.sup.5 -(1H-imidazol-2-yl)-ornithinamide.

Abstract: New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.

Abstract: Amino acid derivatives, suitable for the treatment of obesity. The following compound is exemplary of the class: (R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-argininamide-acetate.

Abstract: New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R.sup.1 to R.sup.7 are as defined herein, as well as the salts thereof with inorganic or organic acids and processes for preparing them.These compounds are useful for improving or normalising arteriosclerotically induced disorders of cerebral blood flow, for treating diseases of the central nervous system, particularly Alzheimer's disease and Parkinson's disease, and as vagal pacemakers for treating bradycardia and bradyarrhythmia, and also for improving memory performance.

Abstract: Pharmaceutical compositions are described which contain 1,5,6,7-tetrahydro-4H-indazol-4-ones of the formula ##STR1## some of these substances themselves being new. The pharmaceutical compositions may be used as analgesics, antipyretics and antiphlogistics.

Abstract: Condensed diazepinones of general formula I ##STR1## in which]B represents one of the divalent groups ##STR2## X is a .dbd.CH-- group or a nitrogen atom,R represents a lower alkyl radical, which may optionally be further substituted by a phenyl optionally carrying halogen, methyl or methoxy,R.sup.4 and R.sup.5 represent hydrogen, halogen or lower alkyl,R.sup.6 is hydrogen, chlorine or methyl,R.sup.7 and R.sup.8 denote lower alkyl, R.sup.8 also additionally denotes halogen, andm, n, o and p represent the numbers 0, 1, 2 or 3 with the following limitations: the sum of m+n and the sum of o+p each denote the numbers 1, 2 or 3, the sum of n+o and the sum of m+p each denote the numbers 1, 2, 3, 4 or 5, wherein, however, the sum of m+n+o+p must always be greater than 2, andA.sup.1, A.sup.2, A.sup.3 and A.sup.4 denote hydrogen, or, for the case where m, n, o and p each denote the number 1, A.sup.1 and A.sup.2 together or A.sup.3 and A.sup.

Abstract: A method for treating abstructive respiratory passage disorders which comprises the use of 5,11-dihydro-11-[[(1-methyl-4-piperidinyl)-amino]carbonyl]-6H-dibenz[b,e]a zepin-6-one; 5,11-dihydro-11-[(1-methyl-4-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, 5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-dibenz[b,e]azepin-6-on e, alone or in combination.

Abstract: New condensed diazepinones of general formula I are described ##STR1## wherein B represents one of the divalent groups ##STR2## and X.sup.1, X.sup.2, A, R.sup.1 to R.sup.10 and Z are defined as in the specification.

Abstract: A process for the preparation of a prepolymer amide, by hydrolytically polymerizing a lactam/water mixture of a C.sub.12 -aminocarboxylic acid lactam at a temperature in the range from 240-360.degree. C. and a steam pressure in the range of 30-180 bar, and wherein the water content of the lactam/water mixture is in the range of 7.5-30% by weight.

Abstract: A process produces a free flowing, silicic-acid-filled, powdered elastomer wherein the silicic acid employed has the properties set out below:(a) SiO.sub.2 content: about 82-91.5% by weight;(b) metallic oxides: about 0.5-3% by weight;(c) loss on ignition (DIN 55 921/2--measured at 100.degree. C.): about 8-15% by weight;(d) moisture (DIN 53 198--measured at 105.degree. C.): about 2-10% by weight;(e) surface area of the primary particles according to BET: about 40-250 m.sup.2 /g;(f) dibutyl phthalate absorption (ASTM D 2414-79) based on measured weight: about 170-290%.(g) linear average of numerical distribution of secondary particles: about 10-2,000 nm;(h) linear average of volume distribution of secondary particles: about 3-30 um;(i) proportion of secondary particles with a diameter of less than 1 um: about 0.01-5% by weightwherein the percentages of parameters (a) to (c), added up together, must yield 100% by weight.

Abstract: Polyamide powder coating compositions for the coating of metals at high temperatures are obtained by the precipitation method from polyamides having at least 10 aliphatically bound carbon atoms per carbonamide group, copolyamides having at least 70% of these polyamides and mixtures of homopolyamides and copolyamides having at least 70% of these polyamides.A. For the preparation of powder coating compositions useful in the fluidized bed coating method the polyamides with 10 or more carbon atoms and having a relative viscosity between 1.4 and 1.8 are added to at least twice the amount by weight of ethanol and while the mixture is being mechanically mixed in a closed vessel is converted into a solution at temperatures between 130.degree. and 150.degree. C. This solution is adjusted to a precipitation temperature of between 100.degree. and 125.degree. C. while avoiding the formation of local sub-cooling and is agitated under an inert gas atmosphere to suppress boiling.

Abstract: A method and apparatus for automatically changing interchangeable machining tool heads carried by a tool carrier. The tool heads are suspended from an overhead trolleyway by leading and trailing trolleys, with the leading trolley carrying a probe and a vertical finger and the trailing trolley carrying an inclined guide. The vertical finger selectively engages a block carried on an overhead moving chain for moving the tool head toward the tool carrier. The probe extends in the direction of tool head travel and is responsive to proximity of the probe to the inclined guide of another tool head or to a pneumatically-actuated stop for disengaging the vertical finger from the chain. A shuttle bar assembly simultaneously loads and unloads tool heads from the tool carrier by engaging a block on each of the tool heads and moving the tool heads horizontally to loaded and unloaded positions.