Patents by Inventor Klaus Rudolf

Klaus Rudolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050234101
    Abstract: Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz
  • CGRP-antagonist in combination with a serotonin-reuptake inhibitor for the treatment of migraine
    Publication number: 20050233980
    Abstract: The present invention relates to a process for the treatment or prevention of headaches, migraine or cluster headache, this process comprising the joint administration of a therapeutically effective amount of the CGRP-antagonist (A) or a physiologically acceptable salt thereof and a therapeutically effective amount of the selective serotonin reuptake inhibitor (B) or a physiologically acceptable salt thereof, as well as the corresponding pharmaceutical compositions and the preparation thereof.
    Type: Application
    Filed: April 19, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henri Doods, Klaus Rudolf
  • Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050234054
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: April 15, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stephan Mueller, Klaus Rudolf, Philipp Lustenberger, Dirk Stenkamp, Kirsten Arndt, Henri Doods, Gerhard Schaenzle
  • Selected CGRP - antagonists, process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050234067
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X, D, E, G, M, Q and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: March 29, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stephan Mueller, Klaus Rudolf, Philipp Lustenberger, Dirk Stenkamp, Alexander Dreyer, Kirsten Arndt, Henri Doods, Gerhard Schaenzle, Marco Santagostino, Fabio Paleari
  • New long acting beta-2-agonists and their use as medicaments
    Publication number: 20050227975
    Abstract: The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1?, R2, R2?, R2?, R2??, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
    Type: Application
    Filed: January 5, 2005
    Publication date: October 13, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Thierry Bouyssou, Ingo Konetzki, Philipp Lustenberger, Juergen Mack, Andreas Schnapp, Dieter Wiedenmayer, Christoph Hoenke, Klaus Rudolf
  • Selected CGRP-antagonists process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050227968
    Abstract: The present invention relates to substituted piperidines of general formula wherein A, B, D, E, X, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: March 3, 2005
    Publication date: October 13, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Philipp Lustenberger, Klaus Rudolf, Stephan Mueller, Dirk Stenkamp, Henri Doods, Kirsten Arndt, Gerhard Schaenzle
  • Medicaments for the treatment of chronic obstructive pulmonary disease
    Publication number: 20050222144
    Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: May 18, 2005
    Publication date: October 6, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
  • Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Publication number: 20050215546
    Abstract: The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: May 26, 2005
    Publication date: September 29, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Mueller, Dirk Stenkamp, Phillipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
    Patent number: 6949541
    Abstract: The present invention relates to substituted piperidines of general formula wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: September 27, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Klaus Rudolf, Henri Doods, Eckhart Bauer, Rudolf Hurnaus, Wolfgang Eberlein, Alexander Dreyer, Stephan Georg Mueller
  • Substituted imidazoles, their preparation and use
    Patent number: 6908926
    Abstract: Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: June 21, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dörwald, Knud Erik Andersen, Tine Krogh Jørgensen, Bernd Peschke, Birgitte Schjellerup Wulff, Ingrid Pettersson, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Müller, Bernd Krist
  • Use of CGRP antagonists in treatment and prevention of hot flushes in prostate cancer patients
    Publication number: 20050032783
    Abstract: The invention relates to a method of treatment or prevention of hot flushes in men who underwent castration, e.g. due to androgen ablation treatment in prostate cancer therapy, comprising administration of an effective amount of a CGRP antagonist and/or of a CGRP release inhibitor to the patient, and to the use of said active compounds for the manufacture of a pharmaceutical composition intended to be used in this method.
    Type: Application
    Filed: June 30, 2004
    Publication date: February 10, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henri Doods, Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Mats Hammar, Anna-Clara Spetz
  • Treatment of migraine
    Publication number: 20040248816
    Abstract: The present invention relates to a process for the treatment or prevention of headache, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of the hydrochloride of the active substance base 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]-carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine (A) and of a therapeutically effective amount of the anti-migraine substance sumatriptan or a physiologically acceptable salt thereof, and the corresponding pharmaceutical compositions and the preparation thereof.
    Type: Application
    Filed: March 29, 2004
    Publication date: December 9, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Henri Doods, Klaus Rudolf, Wolfgang Eberlein
  • New carboxamide compounds having melanin concentrating hormone antagonistic activity, pharmaceutical preparations comprising these compounds and process for their manufacture
    Publication number: 20040242572
    Abstract: The present invention relates to carboxamide compounds of general formula I 1
    Type: Application
    Filed: August 22, 2003
    Publication date: December 2, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Martin Lenter, Heike-Andrea Wieland, Klaus Rudolf, Stephan George Mueller, Ralf R.H. Lotz, Kirsten Arndt, Philipp Lustenberger, Thorsten Lehmann-Lintz
  • Modified amino acids, pharmaceuticals containing these compounds and method for their production
    Publication number: 20040214819
    Abstract: The present invention relates to modified amino acids of general formula 1
    Type: Application
    Filed: April 29, 2004
    Publication date: October 28, 2004
    Applicant: Dr. Karl Thomae GmbH
    Inventors: Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Helmut Pieper, Henri Doods, Gerhard Hallermayer, Michael Entzeroth, Wolfgang Wienen
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20040209865
    Abstract: The present invention relates to alkyne compounds of general formula I 1
    Type: Application
    Filed: October 30, 2003
    Publication date: October 21, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Dirk Stenkamp, Stephan Georg Mueller, Gerald Juergen Roth, Thorsten Lehmann-Lintz, Klaus Rudolf, Philipp Lustenberger, Kirsten Arndt, Ralf R.H. Lotz, Martin Lenter
  • Carboxylic acids and the esters thereof, pharmaceutical compositions thereto and processes for the preparation thereof
    Publication number: 20040192729
    Abstract: The present invention relates to carboxylic acids and esters of general formula 1
    Type: Application
    Filed: January 12, 2004
    Publication date: September 30, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Stephan Georg Mueller, Marcus Schindler, Dirk Stenkamp, Eckhart Bauer, Kai Gerlach, Rudolf Hurnaus
  • Lens
    Publication number: 20040174607
    Abstract: In an objective (1), in particular a microscope objective, said objective comprising an object-side first optical group (5) with a positive refractive power, and a second optical group (6), arranged following the first optical group (5), with a negative refractive power, and said first optical group (5) including several refractive elements (7, 8, 9, 10), the first optical group (5) comprises at least one diffractive element (11) having a refraction-enhancing and achromatizing effect.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 9, 2004
    Inventors: Robert Brunner, Knut Hage, Hans-Jurgen Dobschal, Klaus Rudolf, Reinhard Steiner
  • Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
    Publication number: 20040152742
    Abstract: The present invention relates to amide compounds of general formula I 1
    Type: Application
    Filed: October 31, 2003
    Publication date: August 5, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Dirk Stenkamp, Stephan Georg Mueller, Gerald Juergen Roth, Philipp Lustenberger, Klaus Rudolf, Thorsten Lehmann-Lintz, Kirsten Arndt, Ralf Lotz, Martin Lenter, Heike-Andrea Wieland
  • Carbazole derivatives for the treatment of NPY related diseases
    Publication number: 20040147752
    Abstract: The invention relates to novel carbazole derivatives, their use for the preparation of a pharmaceutical composition for the treatment of eating and metabolic disorders such as obesity, bulimia nervosa, anorexia nervosa, of sleep disturbance, of morphine withdrawal symptoms and of epileptic seizures, a pharmaceutical composition containing them and a process for preparing them.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 29, 2004
    Applicants: Boehringer Ingelheim International GmbH, Novo Nordisk A/S
    Inventors: Klaus Rudolf, Rudolf Hurnaus, Wolfgang Eberlein, Wolfhard Engel, Heike-Andrea Wieland, Bernd Krist
  • New medicaments for the treatment of chronic obstructive pulmonary disease
    Publication number: 20040147513
    Abstract: A pharmaceutical composition comprising a compound of formula 1 1
    Type: Application
    Filed: November 10, 2003
    Publication date: July 29, 2004
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf