Patents by Inventor Klaus Rudolf

Klaus Rudolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of selected CGRP-antagonists in combination with other antimigraine drugs for the treatment of migraine
    Publication number: 20060142273
    Abstract: The present invention relates to a process for the treatment or prevention of indications which are selected from among the group comprising headaches, migraine and cluster headaches, this process comprising the joint administration of a therapeutically effective amount of a selected CGRP antagonist (A), a physiologically acceptable salt thereof or a hydrate of the salt and a therapeutically effective amount of a second or third active anti-migraine medicament (B), particularly sumatriptan, zolmitriptan or dihydroergotamine or a physiologically acceptable salt thereof, and to the corresponding pharmaceutical compositions and the preparation thereof.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International Gmbh
    Inventors: Klaus RUDOLF, Henri DOODS, Stephan MUELLER, Annette ZAMPONI, Philipp LUSTENBERGER, Kirsten ARNDT, Gerhard SCHAENZLE, Dirk STENKAMP, Rolf-Stefan Brickl
  • Use of selected CGRP antagonists for combating menopausal hot flushes
    Publication number: 20060142274
    Abstract: The invention relates to the use of selected CGRP antagonists, the physiologically acceptable salts thereof or the hydrates of the hydrates of the salts thereof for combating menopausal hot flushes.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 29, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Henri Doods, Stephan Mueller, Annette Zamponi, Philipp Lustenberger, Kirsten Arndt, Gerhard Schaenzle, Dirk Stenkamp, Rolf-Stefan Brickl
  • Medicaments for the treatment of chronic obstructive pulmonary disease
    Patent number: 7056916
    Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R2 is hydrogen, C1–C4-alkyl, halogen, OH, or —O—C1–C4-alkyl; R3 is hydrogen, C1–C4-alkyl, OH, halogen, —O—C1–C4-alkyl, —O—C1–C4-alkylene-COOH, or —O—C1–C4-alkylene-CO—O—C1–C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof; and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: June 6, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
  • New Medicaments for the Treatment of Chronic Obstructive Pulmonary Disease
    Publication number: 20060106213
    Abstract: A pharmaceutical composition comprising a compound of formula 1 wherein: n is 1 or 2; R1 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R2 is hydrogen, C1-C4-alkyl, halogen, OH, or —O—C1-C4-alkyl; R3 is hydrogen, C1-C4-alkyl, OH, halogen, —O—C1-C4-alkyl, —O—C1-C4-alkylene-COOH, or —O—C1-C4-alkylene-CO—O—C1-C4-alkyl, or an acid addition salt thereof with a pharmacologically acceptable acid, or a solvate or hydrate thereof, and a pharmaceutically acceptable excipient or carrier, and methods for using the pharmaceutical formulation in the treatment of chronic obstructive pulmonary disease (COPD).
    Type: Application
    Filed: January 26, 2006
    Publication date: May 18, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Ingo Konetzki, Kurt Schromm, Hermann Schollenberger, Sabine Pestel, Andreas Schnapp, Thierry Bouyssou, Frank Buettner, Claudia Heine, Philipp Lustenberger, Christoph Hoenke, Klaus Rudolf
  • Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
    Publication number: 20060079504
    Abstract: The present invention relates to CGRP antagonists of general formula wherein A, U, V, W, X and R1 to R3 are defined as in claim 1, the tautomers, diastereomers, enantiomers, hydrates, mixtures thereof and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them.
    Type: Application
    Filed: October 16, 2003
    Publication date: April 13, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co., KG
    Inventors: Klaus Rudolf, Stephan Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Eckhart Bauer, Marcus Schindler, Kirsten Arndt, Henri Doods
  • Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Patent number: 7026312
    Abstract: The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: April 11, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050282857
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: April 15, 2005
    Publication date: December 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Stephan Mueller, Philipp Lustenberger, Dirk Stenkamp, Gerhard Schaenzle, Kirsten Arndt, Henri Doods
  • Novel medicaments for the treatment of respiratory diseases
    Publication number: 20050272726
    Abstract: The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of respiratory complaints.
    Type: Application
    Filed: April 19, 2005
    Publication date: December 8, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ingo Konetzki, Thierry Bouyssou, Philipp Lustenberger, Frank Buettner, Andreas Schnapp, Christoph Hoenke, Sabine Pestel, Klaus Rudolf, Hermann Schollenberger, Kurt Schromm, Claudia Heine
  • Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof
    Publication number: 20050267137
    Abstract: A compound of general formula (I) wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing the compound, their use, and processes for preparing them.
    Type: Application
    Filed: June 27, 2005
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Wolfgang Eberlein, Wolfhard Engel, Klaus Rudolf, Henri Doods, Gerhard Hallermayer, Eckhart Bauer
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050267115
    Abstract: Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050267120
    Abstract: Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz
  • Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050267093
    Abstract: Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or treating metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes using these compounds.
    Type: Application
    Filed: December 23, 2004
    Publication date: December 1, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Thorsten Lehmann-Lintz, Ralf Lotz, Philipp Lustenberger, Stephan Mueller, Gerald Roth, Klaus Rudolf, Marcus Schindler, Dirk Stenkamp, Leo Thomas
  • Substituted cycloalkyl derivatives, process for the manufacture thereof and use thereof as medicament
    Publication number: 20050261286
    Abstract: The present invention relates to compounds of formula 1 wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
    Type: Application
    Filed: May 10, 2005
    Publication date: November 24, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ingo Konetzki, Thierry Bouyssou, Philipp Lustenberger, Andreas Schnapp, Christoph Hoenke, Klaus Rudolf, Marco Santagostino
  • Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050256099
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X, Q and R1 to R3 are defined as in claim 1, the tautomers, the isomers, the diastereomers, the enantiomers, the hydrates, mixtures and salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: April 20, 2005
    Publication date: November 17, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stephan Mueller, Klaus Rudolf, Philipp Lustenberger, Dirk Stenkamp, Marco Santagostino, Fabio Paleari, Gerhard Schaenzle, Kirsten Arndt, Henri Doods
  • Novel long acting bronchodilators for the treatment of respiratory diseases
    Publication number: 20050256114
    Abstract: The invention relates to compounds of general formula 1 wherein n, A, B, D, L, R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, processes for preparing them, and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
    Type: Application
    Filed: May 10, 2005
    Publication date: November 17, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Matthias Grauert, Thierry Bouyssou, Philipp Lustenberger, Steffen Breitfelder, Andreas Schnapp, Michael Pieper, Klaus Rudolf, Georg Speck
  • Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
    Publication number: 20050250763
    Abstract: The present invention relates to the CGRP antagonists of general formula wherein A, X and R1 to R3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the hydrates thereof, the mixtures thereof and the salts thereof and the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: April 15, 2005
    Publication date: November 10, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Stephan Mueller, Klaus Rudolf, Philipp Lustenberger, Dirk Stenkamp, Kirsten Arndt, Henri Doods, Gerhard Schaenzle
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050245529
    Abstract: Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: November 3, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz
  • Novel medicament combinations for the treatment of respiratory diseases
    Publication number: 20050239778
    Abstract: The present invention relates to new medicament combinations which contain in addition to one or more, preferably one, compound of general formula 1 wherein the groups R1, R2 and R3 may have the meanings given in the claims and in the specification, at least one other active substance 2, processes for preparing them and their use as pharmaceutical compositions.
    Type: Application
    Filed: April 19, 2005
    Publication date: October 27, 2005
    Inventors: Ingo Konetzki, Thierry Bouyssou, Philipp Lustenberger, Michael Pieper, Andreas Schnapp, Christoph Hoenke, Sabine Pestel, Klaus Rudolf, Michel Pairet
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050239826
    Abstract: The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 27, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz
  • Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
    Publication number: 20050234101
    Abstract: Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.
    Type: Application
    Filed: April 13, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Dirk Stenkamp, Stephan Mueller, Philipp Lustenberger, Thorsten Lehmann-Lintz, Gerald Roth, Klaus Rudolf, Marcus Schindler, Leo Thomas, Ralf Lotz