Abstract: The present invention relates to vaccine and treatment of novel coronavirus (SARS-CoV-2) infection (COVID-19) in mammals. Particularly, the invention relates to coronavirus vaccine and method for preparation thereof. More particularly, the present invention discloses preparation of coronavirus vaccine comprising an inactivated, purified SARS-CoV2 as active ingredient. The present invention also discloses a method for preparation of killed-inactivated SARS-CoV-2 virus which is used as antigen in the vaccine composition. The present invention further relates to the method of antigen preparation including inactivation and purification of virus, SARS-CoV-2 vaccine preparation, composition, formulation and use of the same to elicit immune response against the SARS-CoV-2 in mammals, and it is also suitable for immunizing human subjects.

Abstract: Nanogel and nanoparticles comprising vitamin D encapsulated in agar-agar and a polymer selected from poly(acrylamidoglycolic acid) and pectin are provided. Also provided is aqueous nanogel compositions which can be used for prevention or treatment of vitamin D deficiency and methods for encapsulating vitamin D in nanogels and nanoparticles. The nanogel and nanoparticles and compositions thereof are cost-effective, have a considerable shelf life, a faster rate of absorption in the body leading to faster bioavailability. Further, the nanogels and nanoparticles are made with vegetarian sources and causes no changes in the organoleptic properties. The Vitamin D nanogels and nanoparticles developed can be used for fortification of any food, aqueous medium or beverage, including bottled drinking water.

Abstract: In one embodiment, a method comprises maintaining state information regarding a data synchronous replication status for a storage object of a primary storage cluster and a replicated storage object of a secondary storage cluster. The method includes temporarily disallowing input/output (I/O) operations for the storage object when the storage object of the primary storage cluster has a failure, which causes an internal state as out of sync for the storage object while maintaining an external state as in sync for external entities. The method performs persistent inflight tracking and reconciliation of I/O operations with a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster and performs a resynchronization between the storage object and the replicated storage object based on the persistent inflight tracking and reconciliation of I/O operations.

Abstract: A virtual volume (vVol) is non-disruptively migrated from a first data storage appliance (DSS) to a second DSS. In a synchronizing phase, data is copied from a source vVol to a destination vVol which is not mapped and to which a host computer has no path. Upon completion of synchronization, (1) a mapping is created to the destination vVol for the host and signaled to the host by sending a notification having an associated log page, (2) it is determined whether the host has retrieved the log page, (3) in response the host retrieving the log page, a cutover is performed making the destination vVol accessible to the host and the source vVol inaccessible to the host, and (4) in response to the host not retrieving the log page, the cutover is not performed, leaving the destination vVol inaccessible to the host computer (migration may be aborted or retried).

Abstract: Techniques for managing sequencing requests for storage node operations based on types of operations being sequenced. The techniques manage sequencing requests for different types of operations, such as backup and recovery operations, replication operations, migration operations, and so on, in a manner that avoids overwhelming storage node capacity. The techniques include receiving a sequencing request for an operation of a specified operation type at a request manager of a storage node and determining whether a capacity of the storage node is available for running the operation by a capacity manager for the specified operation type, in which the capacity manager is provided by a storage client and implemented on the storage node separate from the request manager. In this way, throttling, limiting, and/or prioritization requirements of the operation of the specified operation type can be defined by the storage client in a manner agnostic to the request manager.

Abstract: Methods (600) and systems (700) for selecting a frequency band for a device. In one aspect, the method comprises receiving (s602) from the device a request for a particular service type. The method further comprises determining (s604) a set of two or more frequency bands that are available for the device. Said set of two or more frequency bands comprises a first frequency band and a second frequency band. The method further comprises selecting (s606), based on the particular service type being requested and at least one of a knowledge base or a machine learning (ML) model, one of the frequency bands included in the set of two or more frequency bands.

Abstract: A virtual volume (vVol) is non-disruptively migrated from a first data storage appliance (DSS) to a second DSS. In a synchronizing phase, data is copied from a source vVol to a destination vVol which is not mapped and to which a host computer has no path. Upon completion of synchronization, (1) a mapping is created to the destination vVol for the host and signaled to the host by sending a notification having an associated log page, (2) it is determined whether the host has retrieved the log page, (3) in response the host retrieving the log page, a cutover is performed making the destination vVol accessible to the host and the source vVol inaccessible to the host, and (4) in response to the host not retrieving the log page, the cutover is not performed, leaving the destination vVol inaccessible to the host computer (migration may be aborted or retried).

Abstract: A method including receiving, from a server, a backoff data packet including first information and second information. The first information includes a backoff command to cease transmitting at least some requests to a service executing on the server, and The second information includes metadata. The method also includes adding the backoff data packet to cached data stored in a cache. The method also includes receiving, from a client, a request data packet including a request for the service. The method also includes comparing request information, associated with the request data packet, to the cached data, including at least comparing the request information to the metadata. The method also includes blocking, responsive to a match between the request information and the cached data, the request data packet from being transmitted to the service.

Abstract: In one embodiment, a method comprises maintaining state information regarding a data replication status for a storage object of the storage node of a primary storage cluster with the storage object being replicated to a replicated storage object of a secondary storage cluster, temporarily disallowing input/output (I/O) operations when the storage object has a connection loss or failure. The method further includes initiating a resynchronization between the storage object and the replicated storage object including initiating asynchronous persistent inflight tracking and replay of any missing I/O operations that are missing from one of a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster, and allowing new I/O operations to be handled with the storage object of the primary storage cluster without waiting for completion of the asynchronous persistent inflight tracking and replay at the secondary storage cluster.

Abstract: Systems and methods are described for performing persistent inflight tracking of operations (Ops) within a cross-site storage solution. According to one embodiment, a method comprises maintaining state information regarding a data synchronous replication status for a first storage object of a primary storage cluster and a second storage object of a secondary storage cluster. The method includes performing persistent inflight tracking of I/O operations with a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster, establishing and comparing Op ranges for the first and second Op logs, and determining a relation between the Op range of the first Op log and the Op range of the second Op log to prevent divergence of Ops in the first and second Op logs and to support parallel split of the Ops.

Abstract: The present invention provides an improved process for the preparation of Sugammadex sodium of formula (I) having more than 98.5% purity along with less than 1.0% monohydroxy Sugammadex sodium and less than 0.15% any other known or unknown impurities by HPLC.

Abstract: Apparatuses, systems, and techniques to update a machine learning model associated with an object. In at least one embodiment, the machine learning model is updated based at least in part on, for example, one or more distributions associated with the machine learning model.

Abstract: The invention relates to novel agonist vaccine formulation, wherein the agonist is novel TLR7/8 agonist which is used as an adjuvant or an immunomodulator. More particularly, the invention relates to the preparation of vaccine formulations against viral infections using Algel-IMDG as an adjuvant. The invention also relates to development of vaccine formulations for severe viral infections using the novel Algel-IMDG as an adjuvant that comprises TLR 7/8 agonist chemisorbed on to surface of Aluminium hydroxide gel. The invention also relates to the use of novel Algel-IMDG formulation as an adjuvant in Vaccine composition against several other viral diseases like Covid-19 caused by SARS-CoV-2 either wild type or its variants, Japanese Encephalitis, recombinant Hepatitis B surface antigen etc.

Abstract: Techniques are provided for persistent hole reservation. For example, hole reservation flags of operations targeting a first storage object of a first node are replicated into replication operations targeting a second storage object of a second node during a transition operation to transition the first storage object and the second storage object from an asynchronous replication state to a synchronous replication state. In another example, the second storage object is grown to a size of a replication punch hole operation that failed due to targeting a file block number greater than an end of size of the second storage object.

Abstract: Methods and systems for unlocking an access point of a facility with a mobile device. Permissions and locations of access points of the facility that are accessible to a user of a particular mobile device may be downloaded and a location of the particular mobile device determined. The mobile device may identify one or more access points of the facility that are accessible by the user of the mobile device based on the location of the mobile device and the downloaded permissions and locations of the access points. The method may include displaying on the mobile device a notification of the access points that are identified by the mobile device, receiving a selection of one of the displayed access points from the user via a user interface of the mobile device, sending a command from the mobile device to unlock the selected access point, and unlocking the selected access point.

Abstract: Techniques are provided for freeing and utilizing unused inodes. For example, an operation, targeting a first storage object of a first node having a replication relationship with a second storage object of a second node, is intercepted. A replication operation is created as a replication of the operation. The operation is implemented upon the first storage object and the replication operation is implemented upon the second storage object. A determination is made that the replication operation uses an inode no longer used by storage objects of the second node. The inode targeted by the replication operation is freed and utilized based upon the inode being a leaf inode. If the inode is a stream directory inode, then data streams of the stream directory inode are moved under a new private inode and the stream directory inode is released.

Abstract: Techniques are provided for inofile management and access control list file handle parity. For example, operations targeting a first storage object of a first node are replicated to a second storage object of a second node. A size of an inofile maintained by the second node is increased if an inode number to be allocated by the replication operation is greater than a current size of the inofile. Access control list file handle parity is achieved by maintaining parity between inode number and generation number pairings of the first node and the second node.

Abstract: According to an aspect of an embodiment, a base station configured for enhanced receiver sensitivity may comprise a processing device and a receiver. The receiver (Rx) may be configured to receive an Rx output signal in an Rx band. The processing device may be configured to receive the Rx output signal from the receiver on an Rx path and receive a crest factor reduction (CFR) output signal from a CFR on a transmit (Tx) path. The processing device may be configured to calibrate the CFR output signal based on the Rx output signal to generate a non-linear actuation (NA) input signal and generate an intermodulation distortion signal by using an NA function on the NA input signal.

Abstract: The present invention relates to pharmaceutical compositions comprising a kinase inhibitor. More particularly, the present invention relates to immediate release pharmaceutical compositions comprising Ribociclib or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients and process for preparing such compositions.

Abstract: A system includes a receiver (RX) configured to receive an RX output signal in an RX band, where the RX output signal has a first passive intermodulation (PIM) source in the RX band and a second PIM source in the RX band; and a processing device configured to: receive the RX output signal from the receiver on an RX path, receive a crest factor reduction (CFR) output signal from a CFR on a transmit (TX) path, identify the first PIM source and the second PIM source based on the RX output signal and the CFR output signal, calibrate the CFR output signal based on the first and second PIM sources in the RX output signal to generate a non-linear actuation (NA) input signal, and generate an intermodulation distortion signal by using an NA function on the NA input signal.