Abstract: Provided herein, inter alia, are compositions, methods, and systems for efficient genetic manipulation of myelod cells without the use of viral vectors. Further provided are strategies for gene disruption in primary myeloid cells (e.g. of human and murine origin) using electroporation-based delivery of Cas/ribonuclear proteins (RNPs). Methods provided herein including embodiments thereof can provide near population-level genetic knockout of single and multiple targets in a range of cell types without selection or enrichment. Cellular fitness and response to immunological stimuli may be unaffected by the gene editing process.

Abstract: Methods and systems for unlocking an access point of a facility with a mobile device. Permissions and locations of access points of the facility that are accessible to a user of a particular mobile device may be downloaded and a location of the particular mobile device determined. The mobile device may identify one or more access points of the facility that are accessible by the user of the mobile device based on the location of the mobile device and the downloaded permissions and locations of the access points of the facility. The method may include displaying on the mobile device a notification of the access points that are identified by the mobile device, receiving a selection of one of the displayed access points from the user via a user interface of the mobile device, sending a command from the mobile device to unlock the selected access point, and unlocking the selected access point.

Abstract: Techniques are provided for dependency aware parallel splitting of operations. For example, a first operation and a second operation may be replicated in parallel from a first device to a second device if the operations only target a single common inode that is an access control list inode referenced by the operations. An operation that dereferences the access control list inode can be replicated in parallel with other operations if the operation does not have the potential to delete the access control list inode from the second device. In another example, operations may be replicated to the second device in parallel if the operations only affect a single common parent directory inode and where timestamps are only moved forward in time at the second device.

Abstract: The present invention relates to pharmaceutical compositions comprising trifluridine and tipiracil hydrochloride. More particularly, the present invention relates to a tablet composition comprising trifluridine, tipiracil hydrochloride and one or more pharmaceutically acceptable excipients and process for preparing such compositions.

Abstract: Techniques are provided for selectively allowing or blocking services from utilizing snapshots. A splitter intercepts and assigns timestamps to operations for execution upon files of a file system. If a snapshot is created while there are no pending operation, then the snapshot is tagged to indicate that the snapshot was created while there were no pending operations, and the snapshot is considered a tagged snapshot. Otherwise, the snapshot is not tagged, and is considered an untagged snapshot. Storage services (e.g., backup applications, lifecycle management applications, applications that consider timestamps of files, etc.) are allowed to utilize tagged snapshots and are blocked from utilizes untagged snapshots in order to maintain consistency.

Abstract: Techniques are provided for handling misaligned holes and writes beyond end of files during a quick reconciliation process. During quick reconciliation, a read operation is performed to read data from a first storage object and is replicated to a second storage object. If the data read from the first storage object comprises misaligned holes, then a different range of data is read from the first storage object so that aligned holes are read and replicated to the second storage object. If the read operation targets a region beyond an end of the first storage object, then the second storage object is truncated to a size of the first storage object.

Abstract: Disclosed are systems, methods, and media having at least one processor; and a non-transitory computer-readable medium storing instruction which, when executed by the at least one processor, cause the at least one processor to perform operations comprising receiving from one or more sources images related to a plurality of features of housing offerings, said images being associated with other images related to features of housing offerings; presenting to a first user an initial prompt and based on response to that initial prompt, presenting a plurality of selectable images related to a first feature of housing offerings; receiving from the first user input regarding the desirability of the images related to the first feature of housing offerings; and iteratively deriving, based on inputs regarding the desirability of the images related to one or more of the plurality of features of housing offerings, a hypothesis regarding a different feature of housing offerings; based at least in part on the hypothesis, pre

Abstract: A request is received to retrieve at least a portion of a file from a compressed data archived image stored in a backup storage device. The compressed data archived image comprises a backup of a file system having a number of directories and a number of files. The compressed data archived image comprises a file that includes a compression of the number of files. An address of the at least the portion of the file within the compressed data archived image is determined. The at least the portion of the file is retrieved at the address in the compressed data archived image, without decompressing the compressed data archived image.

Abstract: Generating a composite screenshot including contextually relevant screenshots and displayed information. The composite screenshot includes one or more screenshots captured from a display screen of a requesting user. Contextual relevance is determined according to collected user communications data such as IoT interactions, social media posts, and chat session transcripts.

Abstract: Systems and methods are described for performing persistent inflight tracking of operations (Ops) within a cross-site storage solution. According to one embodiment, a method comprises maintaining state information regarding a data synchronous replication status for a first storage object of a primary storage cluster and a second storage object of a secondary storage cluster. The method includes performing persistent inflight tracking of I/O operations with a first Op log of the primary storage cluster and a second Op log of the secondary storage cluster, establishing and comparing Op ranges for the first and second Op logs, and determining a relation between the Op range of the first Op log and the Op range of the second Op log to prevent divergence of Ops in the first and second Op logs and to support parallel split of the Ops.

Abstract: A method for preparing microbial contamination free spices and food products is provided. The invention relates to method for preparing cryogenic grinded and cold pasteurized (gamma irradiated) spices and spice related products which retains essential oils, aroma taste and color of the products and is free of any microbial contamination. The invention also relates to such microbial contamination free food products and spices thereof.

Abstract: An indication is received. The indication is for a wireless communication being made by a computing device. Responsive to receiving the indication, an optimized location to make the wireless communication is determined based on a location of the computing device and an optimized locations list. The optimized location is communicated to the computing device making the wireless communication.

Abstract: In some embodiments, an apparatus includes providing a representation of a set of digital medical images to a first machine learning model to define a feature vector associated with a presence of an intracranial hemorrhage. A representation of the set of digital medical images is provided to a second machine learning model to define a second feature vector associated with a volume of the intracranial hemorrhage. Using a third machine learning model, a set of EMRs associated with risk factors for a predefined indication is analyzed to define a third feature vector. The first, second and third feature vectors are provided as inputs to a fourth machine learning model to determine a metric associated with an applicability of a specific treatment associated with a predefined indication. An alert is sent to relevant healthcare providers and relevant tests, procedures or bloodwork are ordered for the predefined indication.

Abstract: Disclosed are systems, methods, and media having at least one processor; and a non-transitory computer-readable medium storing instruction which, when executed by the at least one processor, cause the at least one processor to perform operations comprising receiving from one or more sources images related to a plurality of features of housing offerings, said images being associated with other images related to features of housing offerings; presenting to a first user an initial prompt and based on response to that initial prompt, presenting a plurality of selectable images related to a first feature of housing offerings; receiving from the first user input regarding the desirability of the images related to the first feature of housing offerings; and iteratively deriving, based on inputs regarding the desirability of the images related to one or more of the plurality of features of housing offerings, a hypothesis regarding a different feature of housing offerings; based at least in part on the hypothesis, pre

Abstract: The present invention relates to an improved and industrially viable process for the preparation of Acalabrutinib and its Intermediates. The present invention involves less expensive reagents, solvents and the process conditions can be easily adopted for commercial scale. The present invention relates to process for the preparation Acalabrutinib of formula (1) and process for the preparation of Acalabrutinib key starting material.

Abstract: Techniques are provided for dependency aware parallel splitting of operations. For example, a count of pending data operations being executed by a first node and replicated in parallel to a second node are tracked. A metadata operation is executed at the first node based upon the count being less than a threshold (e.g., the count being zero). A first list of affected inodes modified by the metadata operation is identified. A dependency of the metadata operation with respect to pending metadata operations replicated to the second node is determined. The metadata operation is dispatched to the second node based upon the dependency indicating that the metadata operation is independent of the pending metadata operations.

Abstract: An apparatus may be used with an elongate member that includes an engagement member, a hollow shaft, a compression member, a compression element, and a resilient gripping member. The hollow shaft extends from the engagement member along a longitudinal axis. The compression member is slidably disposed over the hollow shaft. The hollow shaft is disposed over the resilient gripping member and supports the compression element. The compression member has a conical inner surface including a detent feature. The conical inner surface is configured to urge the compression element radially inwards as the collar advances from the unlocked position toward the locked position where the detent feature retains the compression element. The compression element deforms the resilient gripping member radially inwards to grip the elongate member and prevents translation of the elongate member. When unlocked, the resilient gripping member moves radially away from the elongate member allowing translation.

Abstract: Techniques are provided for serializing replication operations. A plurality of operations are implemented upon a first storage object and are replicated as a plurality of replication operations. An order with which the plurality of replication operation are to be executed upon a second storage object is determined. Execution of the plurality of replication operations upon the second storage object is serialized according to the order.

Abstract: The present invention relates to pharmaceutical compositions comprising Ibrutinib. More particularly, the present invention relates to a tablet composition comprising Ibrutinib and one or more pharmaceutically acceptable excipients and process for preparing such compositions.

Abstract: The present application relates to detection units and methods for detecting one or more target analytes in a sample using a complex formed by a target and first and second probes, wherein the complex comprises an elongated region, a particle that is coupled to the first probe, and a solid support that is coupled to the second probe. Specific binding of a target analyte can be distinguished from non-specific binding of the particle by measuring the displacement of the particle.