Patents by Inventor Krisztina Pongracz

Krisztina Pongracz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified oligonucleotides for telomerase inhibition
    Patent number: 9657296
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 23, 2017
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • MODIFIED OLIGONUCLEOTIDES FOR TELOMERASE INHIBITION
    Publication number: 20170130225
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: June 27, 2016
    Publication date: May 11, 2017
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Guanine analogs as telomerase substrates and telomere length affectors
    Patent number: 9593137
    Abstract: This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: March 14, 2017
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Ronald A. Pruzan, Krisztina Pongracz
  • Oligonucleotide conjugates
    Patent number: 9572891
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: February 21, 2017
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • Synthesis of Protected 3'-Amino Nucleoside Monomers
    Publication number: 20160362440
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Application
    Filed: May 16, 2016
    Publication date: December 15, 2016
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • Modified oligonucleotides for telomerase inhibition
    Patent number: 9404112
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: August 2, 2016
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Modified oligonucleotides for telomerase inhibition
    Patent number: 9388415
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 12, 2016
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Modified oligonucleotides for telomerase inhibition
    Patent number: 9388416
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: July 12, 2016
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Synthesis of protected 3?-amino nucleoside monomers
    Patent number: 9365606
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: June 14, 2016
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • RNA AMIDATES AND THIOAMIDATES FOR RNAI
    Publication number: 20160130580
    Abstract: The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3??P5? phosphoramidate (NP) and ribo-N3??P5? thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.
    Type: Application
    Filed: August 6, 2015
    Publication date: May 12, 2016
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Modified Oligonucleotides for Telomerase Inhibition
    Publication number: 20150376624
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: May 18, 2015
    Publication date: December 31, 2015
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Oligonucleotide Conjugates
    Publication number: 20150374841
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Application
    Filed: June 2, 2015
    Publication date: December 31, 2015
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • Modified Oligonucleotides for Telomerase Inhibition
    Publication number: 20150322437
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: May 22, 2015
    Publication date: November 12, 2015
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Modified Oligonucleotides for Telomerase Inhibition
    Publication number: 20150322438
    Abstract: Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
    Type: Application
    Filed: May 22, 2015
    Publication date: November 12, 2015
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • GUANINE ANALOGS AS TELOMERASE SUBSTRATES AND TELOMERE LENGTH AFFECTORS
    Publication number: 20150299232
    Abstract: This invention relates to compounds useful for inhibiting telomere elongation. More specifically, the invention provides nucleotide analogs that are incorporated into telomeres by telomerase thereby inhibiting elongation of telomeres. The compounds are useful in treating cancer and other cell proliferative diseases.
    Type: Application
    Filed: December 21, 2012
    Publication date: October 22, 2015
    Inventors: Sergei M. Gryaznov, Ronald A. Pruzan, Krisztina Pongracz
  • RNA amidates and thioamidates for RNAi
    Patent number: 9133233
    Abstract: The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least one internucleoside linkage chosen from ribo-N3??P5? phosphoramidate (NP) and ribo-N3??P5? thiophosphoramidate (NPS) linkages, and optionally further containing at least one covalently conjugated lipid moiety. Compositions comprising the amidates and thioamidates are disclosed, as are methods for their use in modulating gene expression.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: September 15, 2015
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz
  • Oligonucleotide conjugates
    Patent number: 9072790
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: July 7, 2015
    Assignee: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Richard L. Tolman, Gregg B. Morin
  • PHOSPHORODIAMIDATE BACKBONE LINKAGE FOR OLIGONUCLEOTIDES
    Publication number: 20150111958
    Abstract: This invention relates to antisense oligonucleotides comprising at least one N3??P5? phosphorodiamidate linkage (NPN) in the backbone as well as methods for using the same. The antisense oligonucleotides can effectively prevent or decrease protein expression.
    Type: Application
    Filed: September 26, 2014
    Publication date: April 23, 2015
    Inventors: Krisztina PONGRACZ, Mahesh Ramaseshan
  • SYNTHESIS OF PROTECTED 3'-AMINO NUCLEOSIDE MONOMERS
    Publication number: 20150038692
    Abstract: Orthogonally protected 3?-amino nucleoside monomers and efficient methods for their synthesis are described. The methods employ selective protection of the 3?-amino group in the presence of the unprotected nucleoside base.
    Type: Application
    Filed: May 13, 2014
    Publication date: February 5, 2015
    Applicant: Geron Corporation
    Inventors: Sergei M. Gryaznov, Krisztina Pongracz, Daria Zielinska
  • OLIGONUCLEOTIDE N3'-->P5' THIOPHOSPHORAMIDATES: THEIR SYNTHESIS AND USE
    Publication number: 20140349292
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3?-NHP(O)(S?)O-5? linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3??P5? phosphoramidates and to exhibit a much higher acid stability.
    Type: Application
    Filed: July 9, 2014
    Publication date: November 27, 2014
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray