Patents by Inventor Krisztina Pongracz

Krisztina Pongracz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide N3??P5? thiophosphoramidates: their synthesis and administration to treat neoplasms
    Patent number: 6608036
    Abstract: Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucleotides were found to retain the high RNA binding affinity of the parent oligonucleotide N3′→P5′ phosphoramidates and to exhibit a much higher acid stability.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: August 19, 2003
    Assignee: Geron Corporation
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Tracy Matray
  • Oligonucleotide conjugates
    Publication number: 20030138814
    Abstract: Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an optional linker. The conjugates inhibit telomerase enzyme activity.
    Type: Application
    Filed: September 25, 2002
    Publication date: July 24, 2003
    Inventors: Sergei Gryaznov, Krisztina Pongracz, Gregg B. Morin, Richard L. Tolman