Patents by Inventor Kuei-Ying Lin

Kuei-Ying Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7511125
    Abstract: Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: March 31, 2009
    Assignee: Carlsbad
    Inventors: Kuei-Ying Lin, Mark D. Matteucci
  • Publication number: 20090012037
    Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 27, 2005
    Publication date: January 8, 2009
    Applicant: Gilead Science, Inc.
    Inventors: Constantine G. Boojamra, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Oleg V. Petrakovsky, Adrian S. Ray, Lijun Zhang
  • Patent number: 7452901
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: November 18, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Constantine G. Boojamra, Carina Cannizzaro, James M. Chen, Xiaowu Chen, Aesop Cho, Lee S. Chong, Maria Fardis, Alan X. Huang, Choung U. Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, David Y. Markevitch, Peter H. Nelson, David A. Oare, Vidya K. Prasad, Hyung-Jung Pyun, Adrian S. Ray, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang, Lijun Zhang
  • Patent number: 7439350
    Abstract: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: October 21, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Norbert W. Bischofberger, Robert J. Jones, Murty N. Arimilli, Kuei-Ying Lin, Michael S. Louie, Lawrence R. McGee, Ernest J. Prisbe, William A. Lee, Kenneth C. Cundy
  • Patent number: 7432261
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: April 26, 2004
    Date of Patent: October 7, 2008
    Assignee: Gilead Sciences, Inc.
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph F. Hirschmann, Thorsten Kirschberg, Christopher P. Lee, Kuei-Ying Lin, Richard L. Mackman, Peter H. Nelson, David A. Oare, Hyung-Jung Pyun, Adrian S. Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William J. Watkins, Jennifer R. Zhang
  • Publication number: 20080107628
    Abstract: A compound of Formula I, Formula II, Formula III, or Formula IV: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, therapeutic compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
    Type: Application
    Filed: July 6, 2007
    Publication date: May 8, 2008
    Inventors: Constantine Boojamra, James Chen, Alan Huang, Choung Kim, Kuei-Ying Lin, Richard Mackman, David Oare, Jason Perry, Oliver Saunders, Sundaramoorthi Swaminathan, Lijun Zhang
  • Publication number: 20070049754
    Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: July 26, 2005
    Publication date: March 1, 2007
    Inventors: Constantine Boojamra, Kuei-Ying Lin, Richard Mackman, David Markevitch, Oleg Petrakovsky, Adrian Ray, Lijun Zhang
  • Publication number: 20070010489
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 11, 2007
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Wiliams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Publication number: 20060264404
    Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
    Type: Application
    Filed: October 25, 2005
    Publication date: November 23, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Manoj Desai, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Alan Huang, Haolun Jin, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, William Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Publication number: 20060199788
    Abstract: The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: September 7, 2006
    Inventors: Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Craig Gibbs, Ralph Hirschmann, Thorsten Kirschberg, Christopher Lee, Kuei-Ying Lin, Richard Mackman, Peter Nelson, David Oare, Hyung-Jung Pyun, Adrian Ray, Rosemarie Sherlock, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang
  • Publication number: 20060079478
    Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
    Type: Application
    Filed: April 26, 2004
    Publication date: April 13, 2006
    Inventors: Constantine Boojamra, Carina Cannizzaro, James Chen, Xiaowu Chen, Aesop Cho, Lee Chong, Maria Fardis, Alan Huang, Choung Kim, Thorsten Kirschberg, Steven Krawczyk, Christopher Lee, Kuei-Ying Lin, Richard Mackman, David Markevitch, Peter Nelson, David Oare, Vidya Prasad, Hyung-Jung Pyun, Adrian Ray, Sundaramoorthi Swaminathan, William Watkins, Jennifer Zhang, Lijun Zhang
  • Patent number: 6967079
    Abstract: Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) wherein R1 is a binding partner, a linker or H; a and b are 0 or 1, provided that the total of a and b is 0 or 1; A is N or C; X is S, O, —C(O)—, NH or NCH2R6; Y is —C(O)—; Z is taken together with A to form an aryl or heteroaryl ring structure comprising 5 or 6 ring atoms wherein the heteroaryl ring comprises a single O ring heteroatom, a single N ring heteroatom, a single S ring heteroatom, a single O and a single N ring heteroatom separated by a carbon atom, a single S and a single N ring heteroatom separated by a carbon atom, 2 N ring heteroatoms separated by a carbon atom, or 3 N ring heteroatoms at least two of which are separated by a carbon atom, and wherein the aryl or heteroaryl ring carbon atoms are unsubstituted with other than H or at least 1 nonbridging ring carbon atom is substituted with R6 or ?O; R6 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: November 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Mark Matteucci, Robert J. Jones, Kuei-Ying Lin
  • Publication number: 20050239054
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 27, 2005
    Inventors: Murty Arimilli, Mark Becker, Gabriel Birkus, Clifford Bryant, James Chen, Xiaowu Chen, Tomas Cihlar, Azar Dastgah, Eugene Eisenberg, Maria Fardis, Marcos Hatada, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard MacKman, Martin McDermott, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Patent number: 6951931
    Abstract: Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: October 4, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Kuei-Ying Lin, Mark D. Matteucci
  • Publication number: 20050209197
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: September 22, 2005
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Publication number: 20050020826
    Abstract: Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
    Type: Application
    Filed: August 19, 2004
    Publication date: January 27, 2005
    Inventors: Kuei-Ying Lin, Mark Matteucci
  • Publication number: 20040242465
    Abstract: Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 2, 2004
    Inventors: Norbert W. Bischofberger, Robert J. Jones, Murty N. Arimilli, Kuei-Ying Lin, Michael S. Louie, Lawrence R. McGee, Ernest J. Prisbe, William A. Lee, Kenneth C. Cundy
  • Patent number: 6800743
    Abstract: Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: October 5, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Kuei-Ying Lin, Mark D. Matteucci
  • Publication number: 20030207824
    Abstract: Compounds having particular interest as labels and various novel uses in diagnostics and therapeutics are provided which have structure (1) 1
    Type: Application
    Filed: November 14, 2002
    Publication date: November 6, 2003
    Inventors: Mark D. Matteucci, Robert J. Jones, Kuei-Ying Lin
  • Patent number: RE39324
    Abstract: Compounds having structure (1) wherein R1 is —H a protecting group, a linker or a binding partner; and R2 and R34 are as defined in the specification. The invention also provides intermediates and methods make the structure (1) compounds, as well as methods to use the compounds as labels in diagnostic assays and to enhance binding to complementary bases.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: October 3, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Kuei-Ying Lin, Mark D. Matteucci