Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: Iconic images for a given object or object category may be identified in a set of candidate images by using a learned probabilistic composition model to divide each candidate image into a most probable rectangular object region and a background region, ranking the candidate images according to the maximal composition score of each image, removing non-discriminative images from the candidate images, clustering highest-ranked candidate images to form clusters, wherein each cluster includes images having similar object regions according to a feature match score, selecting a representative image from each cluster as an iconic image of the object category, and causing display of the iconic image. The composition model may be a Naïve Bayes model that computes composition scores based on appearance cues such as hue, saturation, focus, and texture. Iconic images depict an object or category as a relatively large object centered on a clean or uncluttered contrasting background.

Abstract: Systems and methods for providing a loyalty and rewards system that implements a user incentive program using smart card technology are provided. A loyalty system allows a user to systematically search, identify, store, and redeem electronic coupons and rebates associated with products from a large number of providers and manufactures. The loyalty system also integrates the activities associated with the user incentive program (e.g., coupon collection, storage, and redemption, etc.), with existing payment methods (e.g., charging a credit card, etc.) using smart card technology. Thus, the loyalty system allows the user to obtain savings and otherwise participate in the user incentive program without adding time consuming and tedious processing that is normally associated with coupon and rebate programs.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: Systems and methods are described for analyzing a plurality of beats after detection of a suspected cardiac arrhythmia to determine a beat discriminator, identify a beat subsequent to completion of charging of an implantable medical device by applying the beat discriminator, and synchronize delivery of a shock from the medical device to the identified beat. In some examples, identifying the beat using the beat discriminator may help to accurately synchronize the shock with a beat representative of physiological cardiac events instead of an oversensed beat, e.g., noise sensed signal that is misclassified as a cardiac beat.

Abstract: A telecommunications equipment mounting assembly is disclosed herein. The assembly includes a housing adapted for holding telecommunications equipment such as an optical-to-electrical and electrical-to-optical converter modules. The telecommunications equipment mounting assembly also includes an adapter plate removably connected to the housing. The adapted plate includes structure for managing both fiber optic and copper cable.

Abstract: Systems and methods are described for analyzing a plurality of beats after detection of a suspected cardiac arrhythmia to determine a beat discriminator, identify a beat subsequent to completion of charging of an implantable medical device by applying the beat discriminator, and synchronize delivery of a shock from the medical device to the identified beat. In some examples, identifying the beat using the beat discriminator may help to accurately synchronize the shock with a beat representative of physiological cardiac events instead of an oversensed beat, e.g., noise sensed signal that is misclassified as a cardiac beat.

Abstract: A power tool includes a handle including a support portion movably supportable on a housing portion and extending substantially about the circumference of the housing portion. The support portion may include a second end movable relative to a first end such that the support portion selectively applies a force to the housing portion. The tool may include a bevel angle detent mechanism in which one of the detent member and the recess is angularly adjustable relative to the associated one of the detent support and the recess support to adjust the predetermined bevel angle position. A bevel angle detent mechanism may include an engagement operating assembly operable between a detent engagement-enabled condition, in which the detent member is engageable in the recess, and a detent engagement-prevention condition, in which the detent member is prevented from engaging the recess. The tool may include a spindle lock assembly.

Abstract: A power tool, a saw and a circular saw. The power tool may include a handle including a support portion movably supportable on the housing portion and extending substantially about the circumference of the housing portion. The support portion may include a second end movable relative to a first end such that the support portion selectively applies a force to the housing portion. The saw may include a bevel angle detent mechanism in which one of the detent member and the recess is angularly adjustable relative to the associated one of the detent support and the recess support to adjust the predetermined bevel angle position. A bevel angle detent mechanism may include an engagement operating assembly operable between a detent engagement-enabled condition, in which the detent member is engageable in the recess, and a detent engagement-prevention condition, in which the detent member is prevented from engaging the recess. The circular saw may include a spindle lock assembly.

Abstract: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.

Abstract: The present invention provides a method for use in treating a patient with an anticoagulant to optimize drug therapy and/or to prevent an adverse drug response. More particularly, the present invention relates to a method and system for use in treating a patient with Coumadin® or a substance containing warfarin. Methods of the present invention utilize variables that include the patient's CYP4F2 genotype.

Abstract: A method and a system is disclosed for improving transmission of timing advance messages to a mobile station, in a network employing adaptive antenna systems. In a typical embodiment each TA-message is dedicated to one mobile and sent in the adaptive antenna beam that covers the area where the desired mobile is located.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.

Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

Abstract: Iconic images for a given object or object category may be identified in a set of candidate images by using a learned probabilistic composition model to divide each candidate image into a most probable rectangular object region and a background region, ranking the candidate images according to the maximal composition score of each image, removing non-discriminative images from the candidate images, clustering highest-ranked candidate images to form clusters, wherein each cluster includes images having similar object regions according to a feature match score, selecting a representative image from each cluster as an iconic image of the object category, and causing display of the iconic image. The composition model may be a Naïve Bayes model that computes composition scores based on appearance cues such as hue, saturation, focus, and texture. Iconic images depict an object or category as a relatively large object centered on a clean or uncluttered contrasting background.

Abstract: Methods and systems for evaluating biological dataset profiles relating to toxic agents including candidate pharmaceuticals, environmental agents, biowarfare and chemical warfare agents are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate agents.

Abstract: Telecommunications chassis and associated modules for use with the telecommunications chassis are disclosed. Embodiments of the telecommunications chassis include structures such as horizontal channels and/or horizontal surfaces with ridges and/or slots in one surface and slots in ridges of another for receiving edges of modules that mount within the chassis. Other structures of embodiments include divider slots in the horizontal surfaces that receive edges of divider walls to fix the divider walls in place, heat baffle surfaces included within the chassis, and/or cable guides with radius limiters. Module embodiments include structures such as faceplates with angled portions with fiber optic cable connections directed toward the fiber cable's direction of travel. Other module structures include shells that enclose the circuit board and/or provide angled portions with fiber optic cable connections.

Abstract: A system for managing unscheduled maintenance and repair decisions may include a maintenance swap options prioritizer. The maintenance swap options prioritizer may include a data access and transformation module to find and assemble information from different sources for computing performance data and generating a list of prioritized swap options. The maintenance swap options prioritizer may also include an options selection module to generate the list of prioritized swap options based on the information found and assembled by the data access and transformation module and based on any user preferences. The maintenance swap options prioritizer may also include means to present the performance data and list of prioritized swap options to at least one user. The maintenance swap options prioritizer may further include means to permit collaborative decision making and planning by multiple users to manage shared maintenance and repair resources.

Abstract: The present invention provides a method for use in treating a patient with an anticoagulant to optimize drug therapy and/or to prevent an adverse drug response. More particularly, the present invention relates to a method and system for use in treating a patient with Coumadin® or a substance containing warfarin. Methods of the present invention utilize variables that include the patient's CYP4F2 genotype.