Abstract: A magnetic-sensing apparatus and method of making and using thereof is disclosed. The sensing apparatus may be fabricated from semiconductor circuitry and a magneto-resistive sensor. A dielectric may be disposed between the semiconductor circuitry and the magneto-resistive sensor.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: A picture frame having an integrated picture storage area therein is provided. According to a first embodiment, the storage area is attached to the back of a conventional picture frame either during manufacture of by the end user. In this manner the device of the present invention can be utilized with any conventional picture frame assembly. The storage area includes receiver flanges that are mounted to the back of the frame. A storage box is slideably received onto the flanges. In an alternate embodiment, the frame extrusion is modified to include the receiver flanges by forming them with the frame extrusion itself.

Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.

Abstract: A method for fabricating a magnetoresistive device having at least one active region, which may be formed into a magnetic memory bit, sensor element and/or other device, is provided. In forming the magnetoresistive device, a magnetoresistive stack, such as a giant magnetoresistive stack, is formed over a substrate. In addition, a substantially antireflective cap layer formed from titanium nitride, aluminum nitride, and/or other substantially antireflective material, as opposed to the materials commonly used to form a cap layer, is formed over the magnetoresistive stack. The substantially antireflective cap layer is usable as an etch stop for later processing in forming the magnetic memory bit, sensor element and/or other device.

Abstract: The present invention provides the genomic sequences of a library of purified, polynucleotides, or their complements, comprising the genome of Moraxella catarrhalis. The invention also provides the identification of open reading frames contained within the polynucleotides of the library. The present invention further provides for the use of the polynucleotides, their complements or fragments, and proteins or portions thereof for identifying ligands and useful diagnostic and therapeutic compositions. In addition the invention provides for vectors, host cell sand methods for producing M. catarrhalis proteins or portions thereof.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: A retaining system in which straps are provided with hooks that remain engaged with retaining loops even when tension on the straps is released and in which the tightening mechanism includes rods which are located partially below a rib surface on which the straps are placed such that the ends of the rods are near the plane of the strap ends, thereby greatly reducing the bending moment applied to the strap ends and threaded rods. The hook preferably includes a cavity opposite the hook end that will engage the retaining loop when no tension is on the line. In some embodiments, the hook includes a spring-loaded retaining clip to further ensure that the hook does not become disengaged from the retaining loop. The tightening mechanism includes two rods, each of which is positioned to one side of a rib on which the straps rest.

Abstract: The present invention provides the genomic sequences of a library of purified nucleic acid molecules, or their complements, comprising the genome of Moraxella catarrhalis. The invention also provides the identification of open reading frames contained within the nucleic acid molecules of the library. The present invention further provides for the use of the nucleic acid molecules, their complements or fragments, and proteins or portions thereof for identifying ligands and useful diagnostic and therapeutic compositions. In addition the invention provides for vectors, host cells and methods for producing M. catarrhalis proteins or portions thereof.

Abstract: An underground storage tank includes an outer wall having integrally formed ribs, the ribs being closed off by a layer of material applied directly over the space defined created by the ribs and attached to the outer wall, a layer of plastic film or other annular material through which liquid may flow placed over portions of the outer wall between the ribs and extending past the shoulders of the ribs but not extending completely over the material covering the opening of the rib, and an inner wall formed over the annular material and attached to the portion of the material covering the opening provided by the rib that is not covered by the annular material. In this way, the inner wall is tied and preferably chemically and mechanically bonded to the outer wall through the material covering the opening of the rib.

Abstract: The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence of the expressed product indicate that the expression product is involved with the pathway.

Abstract: Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Lea and di-sialyl Lea, which are expressed at the surface of cancer cells, function as a binding partner for LEC-CAMs, such as ELAM-1, which are expressed at the surface of endothelial cells. The present invention also discloses that LEC-CAMs, such as ELAM-1, involved in cancer metastasis share a carbohydrate domain common to both sialyl Lea and sialyl Lex. Antibodies, saccharides, glycoconjugates, enzyme inhibitors and other compounds may be used in the methods of the present invention to inhibit the binding of malignant cells to endothelial cells for a variety of purposes in vivo and in vitro.

Abstract: A toroidal rib suitable for use with a storage tank has a “Y” cross sectional shape including a trunk section and branches. Each of the branches includes a substantially flat upper surface for positioning adjacent to a tank wall. The branches together with the tank wall define an annular space which may be used as part of an annular space in a multiple wall tank. The rib preferably includes a high modulus material such as graphite or steel. The high modulus material may be present in the trunk, branches, or both.

Abstract: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis for rapid identification and characterization of drug candidates, genetic sequences acting pathways, and the like. A feature of the invention is simultaneous screening of a large number of cellular pathways, and the rapid identification of compounds that cause cellular responses.

Abstract: A telecommunications equipment mounting assembly is disclosed herein. The assembly includes a housing adapted for holding telecommunications equipment such as an optical-to-electrical and electrical-to-optical converter modules. The telecommunications equipment mounting assembly also includes an adapter plate removably connected to the housing. The adapted plate includes structure for managing both fiber optic and copper cable.

Abstract: In a method and apparatus for detecting leaks in riser and lid assemblies, a difference in pressure between the inside of the riser and cover assembly and the outside is created and monitored to insure that no leaks exist. Preferably, a vacuum is created on the inside of the riser and cover assembly. This vacuum is then monitored for a set period of time to insure that the total change in pressure does not exceed a threshold. In a highly preferred embodiment, an apparatus automatically creates the desired vacuum and then isolates a vacuum gauge to monitor the vacuum in the riser. Method for isolating a leak are also presented in the event that a leak is detected.

Abstract: A double walled storage tank includes an outer wall, an inner wall, a plurality of ribs disposed between the inner and outer walls, and a plurality of annular spaces between the ribs. The annular space between each pair of ribs is connected to other annular spaces only at the top of the tank. When a leak occurs in either the outer or inner wall, the annular space corresponding to the leak will at least partially drain while the other annular spaces will remain full. Thus, the leak location can be determined by simply examining the annular spaces between pairs of ribs.

Abstract: Clinical patient tissue samples are classified according to the physiological status of cells present in the sample. In some embodiments of the invention, such cells are classified according to their ability to respond to therapeutic agents and treatments. In other embodiments, the cells or tissue samples are classified according to their status with respect to the activity of pathways of interest. The information thus derived is useful in prognosis and diagnosis, and can further be used develop surrogate markers for disease states, and to investigate the effect of genetic polymorphisms in the responsiveness and state of cells involved in disease.