Patents by Inventor Lane A. Smith

Lane A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9701940
    Abstract: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline-like cartilage production from chondrocytes in vivo and in vitro.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 11, 2017
    Assignee: Histogenics Corporation
    Inventors: R. Lane Smith, Laurence J. B. Tarrant, Akihiko Kusanagi, Hans P. I. Claesson
  • Patent number: 9699939
    Abstract: A system and method for cooling electronic devices disposed with a volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids and may contain solid or sealed hollow structures that conform to or occupy space between said electronic devices. Pressure balancing mechanisms are included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: July 4, 2017
    Inventor: David Lane Smith
  • Patent number: 9687590
    Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: June 27, 2017
    Assignee: Histogenics Corporation
    Inventors: Hans Peter Ingemar Claesson, Laurence J. B. Tarrant, Robert Lane Smith, Sonya Shortkroff
  • Publication number: 20170127556
    Abstract: A system and method for cooling electronic devices disposed with a volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids and may contain solid or sealed hollow structures that conform to or occupy space between said electronic devices. Pressure balancing mechanisms are included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Application
    Filed: January 6, 2017
    Publication date: May 4, 2017
    Inventor: David Lane Smith
  • Patent number: 9560789
    Abstract: A system and method for cooling electronic devices disposed with the inner volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The inner volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids and may contain solid or sealed hollow structures that conform to or occupy space between said electronic devices. Pressure balancing mechanisms may be included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: January 31, 2017
    Inventor: David Lane Smith
  • Publication number: 20160367727
    Abstract: One-cartilage constructs suitable for implantation into a joint cartilage lesion in sit-up and a method for repair and restoration of function of injured, traumatic, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.
    Type: Application
    Filed: June 17, 2016
    Publication date: December 22, 2016
    Inventors: Shuichi Mizuno, Akihiko Kusanagi, Laurence J.B. Tarrant, Toshimasa Tokuno, R. Lane Smith
  • Publication number: 20160345461
    Abstract: A system and method for cooling electronic devices disposed with the inner volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The inner volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids and may contain solid or sealed hollow structures that conform to or occupy space between said electronic devices. Pressure balancing mechanisms may be included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Application
    Filed: August 1, 2016
    Publication date: November 24, 2016
    Inventor: David Lane Smith
  • Publication number: 20160331507
    Abstract: A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
    Type: Application
    Filed: July 28, 2016
    Publication date: November 17, 2016
    Inventors: Sonya Shortkroff, Joseph Khoury, Laurence J.B. Tarrant, Hans P.I. Claesson, Robert Lane Smith
  • Publication number: 20160317713
    Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold. A stand alone secondary scaffold implant or unit. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
    Type: Application
    Filed: June 21, 2016
    Publication date: November 3, 2016
    Inventors: Hans Peter Ingemar Claesson, Laurence J.B. Tarrant, Robert Lane Smith, Sonya Shortkroff
  • Patent number: 9421304
    Abstract: A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: August 23, 2016
    Assignee: Histogenics Corporation
    Inventors: Sonya Shortkroff, Joseph Khoury, Laurence J. B. Tarrant, Hans P. I. Claesson, Robert Lane Smith
  • Publication number: 20160228610
    Abstract: Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. The progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. In particular, adipose-derived stem cells and chondrocytes, co-encapsulated in a mixed culture in a polyethylene glycol-based hydrogel comprising an extracellular matrix molecule such as chondroitin sulfate methacrylate, hyaluronic acid methacrylate, or heparan sulfate methacrylate, effectively produce cartilage that can be used for treatment of traumatic injuries or diseases involving cartilage degeneration.
    Type: Application
    Filed: April 25, 2016
    Publication date: August 11, 2016
    Inventors: Janice Lai, William Maloney, R. Lane Smith, Fan Yang
  • Patent number: 9408332
    Abstract: A system and method for cooling electronic devices disposed with the innermost volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The innermost volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids, which may be circulated passively by convection or actively by means of a pump, bubbler, fan, propeller or other means. Pressure balancing mechanisms may be included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: August 2, 2016
    Inventor: David Lane Smith
  • Publication number: 20160206787
    Abstract: A double-structured tissue implant (DSTI) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells. DSTI comprising a primary scaffold and a secondary scaffold consisting of a soluble collagen solution in combination with a non-ionic surfactant generated and positioned within the primary scaffold.
    Type: Application
    Filed: August 20, 2008
    Publication date: July 21, 2016
    Applicant: HISTOGENICS CORPORATION
    Inventors: Sonya Shortkroff, Joseph Khoury, Laurence J.B. Tarrant, Hans P.I. Claesson, Robert Lane Smith
  • Patent number: 9393347
    Abstract: A double-structured tissue implant and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant comprising a primary scaffold comprised of collagen and a secondary scaffold comprising a soluble collagen solution in combination with a surfactant generated and positioned within the primary scaffold. A process for preparation of the double-structured implant or the stand alone secondary scaffold comprising lyophilization and dehydrothermal treatment.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: July 19, 2016
    Assignee: Histogenics Corporation
    Inventors: Hans P. i. Claesson, Laurence J. B. Tarrant, R. Lane Smith, Sonya Shortkroff
  • Patent number: 9393195
    Abstract: Neo-cartilage constructs suitable for implantation into a joint cartilage lesion in situ and a method for repair and restoration of function of injured, traumatized, aged or diseased cartilage. The construct comprises at least chondrocytes incorporated into a support matrix processed according to the algorithm comprising variable hydrostatic or atmospheric pressure or non-pressure conditions, variable rate of perfusion, variable medium composition, variable temperature, variable cell density and variable time to which the chondrocytes are subjected.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: July 19, 2016
    Assignee: Histogenics Corporation
    Inventors: Shuichi Mizuno, Akihiko Kusanagi, Laurence J. B. Tarrant, Toshimasa Tokuno, Robert Lane Smith
  • Publication number: 20160198565
    Abstract: A system and method for heat dissipation and vibration damping of electronic devices in which an assembly is formed by one or more surfaces comprised of thermally conductive plastic that combine to partially or completely enclose one or more electronic devices as a physical and thermal intermediary between the electronic devices and supporting structures.
    Type: Application
    Filed: January 2, 2016
    Publication date: July 7, 2016
    Inventor: David Lane Smith
  • Patent number: 9385897
    Abstract: Methods and apparatus are provided for adapting transmitter equalization coefficients based on receiver gain adaptation. Equalization coefficients of a transmitter that communicates over a channel with a receiver are adapted by determining if a gain value for an amplifier in the receiver is within a limit of the amplifier; and preventing one or more adjustments to the transmitter equalization coefficients if the gain value does not satisfy the upper or lower limit of the amplifier. The gain adjustments comprise, for example, up and down requests for the transmitter equalization coefficients. One or more enable flags can optionally be set based on whether the gain value is within the limit of the amplifier.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: July 5, 2016
    Assignee: Avago Technologies General IP (Singapore) Pte. Ltd.
    Inventors: Vladimir Sindalovsky, Mohammad S. Mobin, Lane A. Smith
  • Publication number: 20160143191
    Abstract: A system and method for cooling electronic devices disposed with the innermost volume of a fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The innermost volume of the sealed container contains one or more single phase or multi-phase thermally conductive fluids, which may be circulated passively by convection or actively by means of a pump, bubbler, fan, propeller or other means. Pressure balancing mechanisms may be included to maintain suitable pressure of gaseous fluid in a volume of the sealed container.
    Type: Application
    Filed: January 4, 2016
    Publication date: May 19, 2016
    Inventor: David Lane Smith
  • Publication number: 20160050797
    Abstract: Temperature, humidity, and pressure control systems and methods for enclosed spaces, including data centers. In some embodiments, the rotational frequency of the air supply fans is controlled based on a pressure associated with the enclosed space. In some embodiments, the rotational frequency of the air supply fans is controlled based on a pressure differential between an inlet region and an exhaust region within the enclosed space. In some embodiments, air within the inlet region is segregated from air within the exhaust region. In some embodiments, the cooling capacity of the cooling equipment is controlled responsive to a temperature associated with the enclosed space. In some embodiments, the cooling capacity is controlled based on a temperature associated with the inlet region of the enclosed space. In some embodiments, the humidity within the enclosed space is controlled.
    Type: Application
    Filed: October 29, 2015
    Publication date: February 18, 2016
    Inventor: Kenneth Lane Smith
  • Patent number: 9258926
    Abstract: A system and method for cooling electronic devices disposed with the innermost volume of a hollow-walled fluid-tight sealed enclosure. Thermally conductive fluids that fill one or more volumes within the hollow walls of said sealed enclosure may be circulated away from said sealed enclosure to an external heat exchange mechanism. The innermost volume of the sealed container contains one or more single phase or multi-phase dielectric thermally conductive fluids, which may be circulated passively by convection or actively by means of a pump, bubbler, fan, propeller or other means. Pressure balancing mechanisms may be included to maintain suitable pressure of gaseous fluid in the innermost volume of the sealed container.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: February 9, 2016
    Inventor: David Lane Smith