Patents by Inventor Lars Barfacker

Lars Barfacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyanopyrimidinones
    Patent number: 8431573
    Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: April 30, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Hendrix, Lars Bärfacker, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen
  • Substituted 4-aryl-1,4-dihydro-1,6-naphthyridines and use thereof
    Patent number: 8404709
    Abstract: The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: March 26, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Santiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Rolf Grosser, Klaus Münter, Andreas Knorr, Adam Nitsche
  • 3-cyano 5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases
    Patent number: 8404723
    Abstract: The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Grant
    Filed: September 8, 2007
    Date of Patent: March 26, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Lars Barfacker, Peter Kolkhof, Karl-Heinz Schlemmer, Rolf Grosser, Adam Nitsche
  • Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same
    Patent number: 8399471
    Abstract: The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is: wherein Ar is an aryl or heteroaryl substituent, and R1, R2, R3, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: March 19, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Santiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Alexander Kuhl, Rolf Grosser, Klaus Münter, Andreas Knorr
  • SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES
    Publication number: 20120322772
    Abstract: The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
    Type: Application
    Filed: August 24, 2012
    Publication date: December 20, 2012
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Ingo FLAMME, Jens-Kerim ERGÜDEN, Felix OEHME, Kai THEDE, Gunter KARIG, Alexander KUHL, Hanno WILD, Joachim SCHUHMACHER, Peter KOLKHOF, Lars BÄRFACKER, Joachim HÜTTER
  • Cyclically substituted furopyrimidine derivatives and use thereof
    Patent number: 8324222
    Abstract: The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: December 4, 2012
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Lampe, Eva-Maria Becker, Raimund Kast, Hartmut Beck, Mario Jeske, Joachim Schuhmacher, Friederike Stoll, Martina Klein, Metin Akbaba, Andreas Knorr, Johannes-Peter Stasch, Lars Bärfacker, Alexander Hillisch, Gunter Karig, Mark Meininghaus, Karl-Heinz Schlemmer, Rudolf Schohe-Loop
  • Dipyridyl-dihydropyrazolones and their use
    Patent number: 8252817
    Abstract: The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
    Type: Grant
    Filed: April 15, 2006
    Date of Patent: August 28, 2012
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ingo Flamme, Jens-Kerim Ergüden, Felix Oehme, Kai Thede, Gunter Karig, Alexander Kuhl, Hanno Wild, Joachim Schuhmacher, Peter Kolkhof, Lars Bärfacker, Joachim Hütter
  • Acyclically substituted furopyrimidine derivatives and use thereof
    Patent number: 8183246
    Abstract: The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: May 22, 2012
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Lampe, Eva-Maria Becker, Raimund Kast, Hartmut Beck, Mario Jeske, Joachim Schuhmacher, Friederike Stoll, Martina Klein, Metin Akbaba, Andreas Knorr, Johannes-Peter Stasch, Lars Bärfacker, Alexander Hillisch, Gunter Karig, Mark Meininghaus, Karl-Heinz Schlemmer, Rudolf Schohe-Loop
  • I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use
    Patent number: 8173665
    Abstract: The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the invention are useful in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: May 8, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenieh, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • Substituted 6-phenylnicotinic acids and their use
    Patent number: 8143411
    Abstract: The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: March 27, 2012
    Assignee: Bayer Animal Health GmbH
    Inventors: Lars Bärfacker, Barbara Albrecht-Küpper, Peter Kolkhof, Yolanda Cancho Grande, Adam Nitsche, Heinrich Meier, Carsten Schmeck, Jens Schamberger, Klemens Lustig
  • 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES
    Publication number: 20120010224
    Abstract: The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: September 15, 2011
    Publication date: January 12, 2012
    Inventors: Martin HENDRIX, Lars Bärfacker, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • Cyanopyrimidinones
    Patent number: 8088769
    Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Grant
    Filed: December 31, 2004
    Date of Patent: January 3, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Hendrix, Lars Bärfacker, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen
  • 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
    Patent number: 8044060
    Abstract: Described are 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolo[3,4-d]pyrimidines of the formula (I): as defined herein, processes for their preparation and their use for producing medicaments for treating impairment of perception, concentration, learning and/or memory.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: October 25, 2011
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Hendrix, Lars Bärfacker, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • CYANOPYRIMIDINONES
    Publication number: 20110207735
    Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: May 2, 2011
    Publication date: August 25, 2011
    Inventors: Martin HENDRIX, Lars BÄRFACKER, Heike Heckroth, Dagmar KARTHAUS, Adrian TERSTEEGEN
  • 3-Cyanoalkyl- and 3-hydroxyalkylindoles and use thereof
    Publication number: 20110183928
    Abstract: The present application relates to novel 3-cyanoalkyl- and 3-hydroxyalkyl-substituted indole derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
    Type: Application
    Filed: June 18, 2009
    Publication date: July 28, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Kai Thede, Elisabeth Woltering, Peter Kolkhof, Carsten Schmeck, Elisabeth Pook, Alexander Hillisch, Lars Bärfacker, Klemens Lustig, Dieter Lang, Martin Radtke, Rolf Grosser, Astrid Brüns, Michael Gerisch
  • Novel, Cyclically Substituted Furopyrimidine Derivatives and Use Thereof
    Publication number: 20110124665
    Abstract: The present application relates to novel, cyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
    Type: Application
    Filed: December 8, 2006
    Publication date: May 26, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Thomas Lampe, Eva-Maria Becker, Raimund Kast, Hartmut Beck, Mario Jeske, Joachim Schuhmacher, Friederike Stoll, Martina Klein, Metin Akbaba, Andreas Knorr, Johannes-Peter Stasch, Lars Bärfacker, Alexander Hillisch, Gunter Karig, Mark Meininghaus, Karl-Heinz Schlemmer, Rudolf Schohe-Loop
  • 6-CYCLYLMETHYL-AND 6-ALKYLMETHYL-SUBSTITUTED PYRAZOLEPYRIMIDINES
    Publication number: 20110065730
    Abstract: The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 17, 2011
    Inventors: Martin Hendrix, Lars Bärfacker, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • SUBSTITUTED 4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINES AND USE THEREOF
    Publication number: 20100305052
    Abstract: The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: June 1, 2007
    Publication date: December 2, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Santiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Rolf Grosser, Klaus Münter, Andreas Knorr
  • 2-PHENOXY NICOTINE ACID DERIVATIVE AND USE THEREOF
    Publication number: 20100298221
    Abstract: The present invention relates to novel 2-phenoxy-6-phenyl- and 2-phenoxy-6-pyridylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, especially of dyslipidemias, arteriosclerosis and heart failure.
    Type: Application
    Filed: August 30, 2007
    Publication date: November 25, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Heinrich Meier, Peter kolkhof, Axel Kretschmer, Arounarith Tuch, Lars Barfacker, Yolanda Cancho Grande
  • 3-Cyano-5-thiazaheteroaryl-dihydropyridine and the use thereof for the treatment of cardiovascular diseases
    Publication number: 20100240620
    Abstract: The present application relates to novel aryl-substituted 3-cyano-5-thiazolyl- and 3-cyano-5-thiadiazolyl-1,4-dihydropyridines, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: September 8, 2007
    Publication date: September 23, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Lars Barfacker, Peter Kolkhof, Karl-Heinz Schlemmer, Rolf Grosser, Adam Nitsche