Patents by Inventor Lars Barfacker

Lars Barfacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF
    Publication number: 20100136142
    Abstract: The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: February 19, 2008
    Publication date: June 3, 2010
    Applicant: BAYER SCHERING PAHARMA AKTIENGESELLSCHAFT
    Inventors: Lars Bärfacker, Peter Kolkhof, Karl-Heinz Schlemmer, Rolf Grosser, Adam Nitsche, Martina Klein, Klaus Münter, Barbara Albrecht-Küpper, Elke Hartmann
  • SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF
    Publication number: 20100099681
    Abstract: The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.
    Type: Application
    Filed: August 13, 2009
    Publication date: April 22, 2010
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Lars Bärfacker, Raimund Kast, Nils Griebenow, Heinrich Meier, Peter Kolkhof, Barbara Albrecht-Küpper, Adam Nitsche, Nicole Teusch, Johannes-Peter Stasch, Dirk Schneider
  • Dihydropyridine derivatives for use as human neutrophil elastase inhibitors
    Patent number: 7691854
    Abstract: The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: April 6, 2010
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes
    Patent number: 7687510
    Abstract: The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: March 30, 2010
    Assignee: Bayer Healthcare AG
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • 5-ARYL-SUBSTITUTED DIHYDROPYRIDOPYRIMIDINES AND DIHYDROPYRIDAZINES AND USE THEREOF AS MINERAL CORTICOID ANTAGONISTS
    Publication number: 20100035902
    Abstract: The present application relates to novel aryl-substituted heterobicyclic compounds, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
    Type: Application
    Filed: May 25, 2007
    Publication date: February 11, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Santiago Figueroa Perez, Peter Kolkhof, Lars Bärfacker, Ingo Flamme, Karl-Heinz Schlemmer, Alexander Kuhl, Rolf Grosser, Klaus Münter, Andreas Knorr
  • 6-Arylmethyl-substituted pyrazolopyrimidines
    Publication number: 20100035900
    Abstract: The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Martin HENDRIX, Lars Bärfacker, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • Dipyridyl-dihydropyrazolones and their use
    Publication number: 20100035906
    Abstract: The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
    Type: Application
    Filed: April 15, 2006
    Publication date: February 11, 2010
    Applicant: BAYER HEALTHCARE AG
    Inventors: Ingo Flamme, Jens-Kerim Ergüden, Felix Oehme, Kai Thede, Gunter Karig, Alexander Kuhl, Hanno Wild, Joachim Schuhmacher, Peter Kolkhof, Lars Bärfacker, Joachim Hütter
  • I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE
    Publication number: 20100022537
    Abstract: This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Application
    Filed: July 27, 2009
    Publication date: January 28, 2010
    Applicant: Bayer Healthcare AG
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenieh, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof
    Publication number: 20090318475
    Abstract: The present application relates to novel, acyclically substituted furopyrimidine derivatives, methods for their production, their use for the treatment and/or prophylaxis of diseases and their use for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular diseases.
    Type: Application
    Filed: December 8, 2006
    Publication date: December 24, 2009
    Applicant: BAYER HEALTHCARE AG
    Inventors: Thomas Lampe, Eva-Maria Becker, Raimund Kast, Hartmut Beck, Mario Jeske, Joachim Schuhmacher, Friederike Stoll, Martina Klein, Metin Akbaba, Andreas Knorr, Johannes-Peter Stasch, Lars Bärfacker, Alexander Hillisch, Gunter Karig, Mark Meininghaus, Karl-Heinz Schlemmer, Rudolf Schohe-Loop
  • 6-arylmethylprazolo[3,4-d]pyrimidines
    Patent number: 7615558
    Abstract: Described are 6-arylmethylpyrazolo[3,4-d]pyrimidines of the following formula: processes for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Grant
    Filed: April 27, 2004
    Date of Patent: November 10, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Hendrix, Lars Bärfacker, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • 1-phenyl1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use
    Patent number: 7566723
    Abstract: The invention relates to novel 1-Phenyl-3,4-dihydropyrimidin-2(1H)-one derivatives having the formula processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: July 28, 2009
    Assignee: Bayer Healthcare AG
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schlemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary F. Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer
  • 6-ARYLAMINO-5-CYANO-4-PYRIMIDINONES AS PDE9A INHIBITORS
    Publication number: 20090111838
    Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
    Type: Application
    Filed: December 19, 2008
    Publication date: April 30, 2009
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Martin HENDRIX, Lars BARFACKER, Bettina BEYREUTHER, Ulrich EBERT, Christina ERB, Frank-Thorsten HAFNER, Heike HECKROTH, Yan-Hong LIU, Dagmar KARTHAUS, Adrian TERSTEEGEN, Franz-Josef VAN DER STAAY, Marja VAN KAMPEN
  • Isophthalic acid derivatives
    Patent number: 7498460
    Abstract: The present invention relates to isophthalic acid derivatives, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular of cardiovascular disorders.
    Type: Grant
    Filed: November 28, 2003
    Date of Patent: March 3, 2009
    Assignee: Bayer Healthcare AG
    Inventors: Michael Härter, Jens Ergüden, Frank Wunder, Hanna Tinel, Johannes Köbberling, Eva-Maria Becker, Klaus Münter, Karl-Heinz Schlemmer, Raimund Kast, Peter Kolkhof, Gunter Karig, Lars Bärfacker, Walter Hübsch, Joachim Schuhmacher, Susanne Zuleger, Arnel Concepcion, Haruka Shimizu
  • 6-arylamino-5-cyano-4-pyrimidinones as pde9a inhibitors
    Patent number: 7488733
    Abstract: The invention relates to novel 6-arylamino-5-cyano-4-pyrimidinones of formula (I) methods for the production thereof, and the use thereof for producing medicaments utilized for improving awareness, concentration, learning capacity, and/or retentiveness of memory. Said compounds (I) show activity as PDE9 inhibitors.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: February 10, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Martin Hendrix, Lars Bärfacker, Bettina Beyreuther, Ulrich Ebert, Christina Erb, Frank-Thorsten Hafner, Heike Heckroth, Yan-Hong Liu, Dagmar Karthaus, Adrian Tersteegen, Franz-Josef van der Staay, Marja van Kampen
  • Novel Pyrimidine Derivatives and their Use
    Publication number: 20080261990
    Abstract: The present invention relates to novel pyrimidine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular diseases, in particular dyslipidemias, arteriosclerosis, coronary heart disease, thrombosis and metabolic syndrome.
    Type: Application
    Filed: September 10, 2005
    Publication date: October 23, 2008
    Applicant: Bayer healthCare AG
    Inventors: Elke Dittrich-Wengenroth, Lars Barfacker, Axel Kretschmer, Claudia Hirth-Dietrich, Peter Ellinghaus, Martin Raabe, Hilmar Bischoff, Christian Pilger, Ulrich Rosentreter, Stephan Bartel, Klemens Lustig, Armin Kern, Dieter Lang, Marcus Bauser
  • Cyanopyrimidinones
    Publication number: 20080255118
    Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.
    Type: Application
    Filed: December 31, 2004
    Publication date: October 16, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Martin Hendrix, Lars Barfacker, Heike Heckroth, Dagmar Karthaus, Adrian Tersteegen
  • Phenylthioacetic Acid Derivatives and Use Thereof
    Publication number: 20080255202
    Abstract: The present application relates to novel phenylthioacetic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
    Type: Application
    Filed: March 26, 2005
    Publication date: October 16, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Hilmar Bischoff, Elke Dittrich-Wengenroth, Nils Griebenow, Axel Kretschmer, Joachim Kruger, Elisabeth Woltering, Lars Barfacker, Claudia Hirth-Dietrich, Peter Ellinghaus, Martin Raabe, Stephen Bartel, Christian Pilger, Ulrich Rosentreter, Klemens Lustig, Armin Kern, Dieter Lang
  • Pyrimidine Carboxylic Acid Derivatives and Use Thereof
    Publication number: 20080194598
    Abstract: The present application relates to pyrimidinecarboxylic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders, in particular dyslipidaemias and arteriosclerosis.
    Type: Application
    Filed: March 7, 2006
    Publication date: August 14, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Elisabeth Woltering, Arounarith Tuch, Elke Dittrich-Wengenroth, Axel Kretschmer, Lars Barfacker, Marcus Bauser, Peter Ellinghaus, Klemens Lustig, Elisabeth Pook, Olaf Weber
  • Phenyl Acetamides
    Publication number: 20080176898
    Abstract: The present invention relates to phenylacetamides, to a process for their preparation and to their use for producing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, especially of cardiovascular disorders.
    Type: Application
    Filed: April 14, 2005
    Publication date: July 24, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Michael Harter, Frank Wunder, Lars Barfacker, Gunter Karig, Walter Hubsch, Hanna Tinel, Eva-Maria Becker
  • Dihydropyridine derivatives for use as human neutrophil elastase inhibitors
    Publication number: 20070167406
    Abstract: The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
    Type: Application
    Filed: August 18, 2003
    Publication date: July 19, 2007
    Inventors: Heike Gielen-Haertwig, Volkhart Min-Jian Li, Ulrich Rosentreter, Karl-Heinz Schiemmer, Swen Allerheiligen, Leila Telan, Lars Bärfacker, Jörg Keldenich, Mary Fitzgerald, Kevin Nash, Barbara Albrecht, Dirk Meurer