Patents by Inventor Lawrence B. Blyn

Lawrence B. Blyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ASSAYS FOR DETECTING SARS-COV-2
    Publication number: 20220043003
    Abstract: The present disclosure relates to methods of detecting a protein from the SARS-CoV-2 virus, or a fragment thereof, in a sample obtained from a subject using a first antibody or antigen-binding fragment thereof that binds to a protein from the SARS-CoV-2 virus, or a fragment thereof, and a second antibody or antigen-binding fragment thereof which binds to a protein from the SARS-CoV-2 virus, or a fragment thereof.
    Type: Application
    Filed: August 4, 2021
    Publication date: February 10, 2022
    Inventors: Lawrence B. Blyn, Mijung Ji, Stephen Kovacs, Anthony S. Muerhoff, Stacey P. Huth, Carsten Buenning, Tao Xin, Donabel Roberts, Sung Hee Kim, Sang Yong Park, Robert N. Ziemann
  • Bioagent detection oligonucleotides
    Patent number: 10662485
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: May 26, 2020
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • BIOAGENT DETECTION OLIGONUCLEOTIDES
    Publication number: 20180230521
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Application
    Filed: April 13, 2018
    Publication date: August 16, 2018
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Bioagent detection oligonucleotides
    Patent number: 9970061
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Grant
    Filed: December 27, 2012
    Date of Patent: May 15, 2018
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
    Patent number: 9752184
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: September 5, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill K. White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 9725771
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: August 8, 2017
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Methods For Rapid Identification Of Pathogens In Humans And Animals
    Publication number: 20170044630
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Application
    Filed: August 15, 2016
    Publication date: February 16, 2017
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • BIOAGENT DETECTION SYSTEMS, DEVICES, AND METHODS
    Publication number: 20160325283
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • Methods for concurrent identification and quantification of an unknown bioagent
    Patent number: 9447462
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: September 20, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Bioagent detection systems, devices, and methods
    Patent number: 9393564
    Abstract: The present invention relates to portable systems and devices, and corresponding methods, for detecting bioagents. In particular, the present invention provides systems, devices, and methods that utilize one or more of a sample preparation component, sample analysis component employing broad range primers, and sample detection component.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: July 19, 2016
    Assignee: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • BIOAGENT DETECTION OLIGONUCLEOTIDES
    Publication number: 20150184231
    Abstract: The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.
    Type: Application
    Filed: December 27, 2012
    Publication date: July 2, 2015
    Inventors: David J. Ecker, Steven A. Hofstadler, Rangarajan Sampath, Lawrence B. Blyn, Thomas A. Hall, Mark W. Eshoo
  • METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS
    Publication number: 20150056620
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Application
    Filed: August 29, 2014
    Publication date: February 26, 2015
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA AND CHARACTERIZATION OF MITOCHONDRIAL DNA HETEROPLASMY
    Publication number: 20150031117
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Application
    Filed: August 11, 2014
    Publication date: January 29, 2015
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill K. White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 8822156
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: September 2, 2014
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Methods For Concurrent Identification And Quantification Of An Unknown Bioagent
    Publication number: 20140141502
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Application
    Filed: January 27, 2014
    Publication date: May 22, 2014
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Methods For Rapid Forensic Analysis Of Mitochondrial DNA
    Publication number: 20130337452
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
    Type: Application
    Filed: March 26, 2013
    Publication date: December 19, 2013
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Steven A. Hofstadler, Thomas A. Hall, David J. Ecker, Lawrence B. Blyn, Mark W. Eshoo, Vivek Samant, Neill White
  • Methods for rapid forensic analysis of mitochondrial DNA
    Patent number: 8407010
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: March 26, 2013
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Thomas A. Hall, David J. Ecker, Lawrence B. Blyn, Mark W. Eshoo, Vivek Samant, Neill White
  • Methods for identifying bioagents
    Patent number: 8268565
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Grant
    Filed: December 2, 2008
    Date of Patent: September 18, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Stephen A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Methods for concurrent identification and quantification of an unknown bioagent
    Patent number: 8187814
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: May 29, 2012
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Methods For Concurrent Identification And Quantification Of An Unknown Bioagent
    Publication number: 20120107795
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Application
    Filed: January 8, 2010
    Publication date: May 3, 2012
    Applicant: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall