Patents by Inventor Lawrence B. Blyn

Lawrence B. Blyn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR USE IN IDENTIFICATION OF STRAINS OF HEPATITIS C VIRUS
    Publication number: 20100291544
    Abstract: The present invention provides compositions, kits and methods for rapid identification and quantification of strains of hepatitis C viruses by molecular mass and base composition analysis.
    Type: Application
    Filed: May 27, 2008
    Publication date: November 18, 2010
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Rangarajan Sampath, Lawrence B. Blyn, Christian Massire
  • Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
    Publication number: 20100145626
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Application
    Filed: October 26, 2009
    Publication date: June 10, 2010
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF PAPILLOMAVIRUS
    Publication number: 20100136515
    Abstract: The present invention relates generally to identification of HPV, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: October 1, 2009
    Publication date: June 3, 2010
    Applicant: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Lawrence B. Blyn, Rachael Kreft, Thomas A. Hall, Feng Li
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF PSEUDOMONAS AERUGINOSA
    Publication number: 20100129811
    Abstract: The present invention relates generally to identification of Pseudomonas aeruginosa bacteria or strains of Pseudomonas aeruginosa, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: October 2, 2009
    Publication date: May 27, 2010
    Applicant: Ibis Biosciences, Inc.
    Inventors: Rangarajan Sampath, Thomas A. Hall, Lawrence B. Blyn, Cristina Ivy, Raymond Ranken, David J. Ecker
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 7718354
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: May 18, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
    Patent number: 7666588
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: February 23, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neil White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Methods for concurrent identification and quantification of an unknown bioagent
    Patent number: 7666592
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: February 23, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • METHODS FOR RAPID IDENTIFICATION OF PATHOGENS IN HUMANS AND ANIMALS
    Publication number: 20090280471
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Application
    Filed: December 5, 2003
    Publication date: November 12, 2009
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall
  • Methods for identifying bioagents
    Publication number: 20090239224
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Application
    Filed: December 2, 2008
    Publication date: September 24, 2009
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • Methods For Rapid Forensic Analysis Of Mitochondrial DNA
    Publication number: 20090125245
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
    Type: Application
    Filed: March 17, 2008
    Publication date: May 14, 2009
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Steven A. Hofstadler, Thomas A. Hall, David J. Ecker, Lawrence B. Blyn, Mark W. Eshoo, Vivek Samant, Neill White
  • METHODS FOR CONCURRENT IDENTIFICATION AND QUANTIFICATION OF AN UNKNOWN BIOAGENT
    Publication number: 20090004643
    Abstract: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis, mass and abundance data are obtained. The identity of the bioagent is then determined from the molecular mass of the bioagent identifying amplicon and the quantity of the identified bioagent in the sample is determined from the abundance data of the bioagent identifying amplicon and the abundance data of the calibration amplicon.
    Type: Application
    Filed: February 17, 2005
    Publication date: January 1, 2009
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: David J. Ecker, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, Thomas A. Hall
  • Methods for rapid detection and identification of bioagents for environmental and product testing
    Patent number: 7255992
    Abstract: The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings, containers, towers and the like, as well as testing of foodstuff and cosmetics.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: August 14, 2007
    Assignee: Isis Pharmaceuticals, Inc
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall
  • Methods for rapid detection and identification of bioagents for environmental and product testing
    Publication number: 20040180328
    Abstract: The present invention provides methods for rapid detection of bioagents for environmental and product testing. The methods can be used for testing air, water, soil, surfaces of buildings, containers, towers and the like, as well as testing of foodstuff and cosmetics.
    Type: Application
    Filed: September 12, 2003
    Publication date: September 16, 2004
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall
  • Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
    Publication number: 20040161770
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Application
    Filed: September 12, 2003
    Publication date: August 19, 2004
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neil White, Vivek Samant, Mark W. Eshoo, Jared J. Drader