Abstract: An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate comprising albumin, a variant or fragment thereof is disclosed.

Abstract: Mechanisms to support orphaned and partially configured objects are provided. A project includes a variety of objects. At least one object is designated as an orphaned object. The orphaned object lacks complete configuration details. Other objects of the project depend on the orphaned object and yet the other objects can load and process within the project as if the orphaned object was fully configured and available.

Abstract: Mechanisms to support object-oriented version control operations are provided. A user manipulates and views a project from an object viewpoint and within an object module. The user performs version control operations using object handles. The object handles are resolved to specific file references and the specific file references are used to process legacy version control commands utilizing a legacy version control system in a manner that is transparent to the user.

Abstract: The embodiments of the invention are directed to a method and apparatus to generate pulsing lights where parameters such as frequency, degree of brightness, and the number of pulses vary depending on the duration of the brake pedal application, the time interval between consecutive brake applications, and the deceleration rate of the vehicle, as well as optionally its distance from other vehicles. The brake light control system incorporates a microprocessor having multiple inputs, including a brake pedal sensor, and its output connected via an amplifying circuit to the lights. Other inputs of the microprocessor include a deceleration sensor, a distance sensor, and an optional manual pushbutton or switch located within the driver's reach. The lights controlled by the system may include brake lights, emergency lights, or additional lights shaped into a warning triangle.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: A trench opener/closer is provided for an agricultural seeding machine movable in a planting direction. The trench opener/closer includes a disc opener assembly, a gauge wheel assembly, a closing assembly, a boot member, and a seed delivery member. The disc opener assembly has a first axis of rotation. The gauge wheel assembly has a second axis of rotation disposed rearward of the first axis of rotation in the planting direction. The closing assembly has a third axis of rotation disposed rearward of the second axis of rotation in the planting direction. The boot member extends between the disc opener assembly and the closing assembly. The seed delivery member is disposed rearward of the disc opener assembly in the planting direction. The seed delivery member is disposed adjacent to both a trailing edge of the boot member and the closing assembly.

Abstract: The present invention relates generally to systems, methods and software applications for storing, retrieving, and displaying information. More particularly, the present invention relates to providing a comprehensive, interactive tool for storing, retrieving, and displaying agent identifying information and agent commission information. The method of the present invention comprises the steps of: receiving agent identifying information and agent commission information; analyzing and sorting the received agent identifying information and agent commission information; saving the agent identifying information and the agent commission information; providing an interactive display of the agent identifying information and the agent commission information; providing interactive access to a display of detailed agent identifying information; and providing interactive access to a display of detailed agent commission information.

Abstract: A process for purifying a transferrin solution and the product of the purification process. A process for producing transferrin and the product of the production process. Use of the transferrin in cell culture, as a pharmaceutical ingredient, as a pharmaceutical product and in a cell culture medium.

Abstract: Mechanisms to persist object relations are provided. A project is defined as a series of interrelated objects having dependencies and relationships with one another. The dependencies and relationships are maintained via a storage organization for files that define the objects within a project storage environment for the project. Thus, the dependencies and relationships are not maintained via hardcoded instructions or references that are included within the files.

Abstract: Mechanisms to support object-oriented version control operations are provided. A user manipulates and views a project from an object viewpoint and within an object module. The user performs version control operations using object handles. The object handles are resolved to specific file references and the specific file references are used to process legacy version control commands utilizing a legacy version control system in a manner that is transparent to the user.

Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Techniques for project lifecycle staged-based access control are provided. Access control rights are defined for a stage of a project's lifecycle. As requestors transition to the stage, the access control rights are enforced on top of any existing security restrictions. In an embodiment, selective resources are not visible to requestors within the stage in response to the access control rights.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Techniques for project management instantiation and configuration are provided. A master project includes policy directives that drive the dynamic instantiation and configuration of resources for a project. The resources are instantiated and configured on demand and when resources are actually requested, in response to the policy directives.

Abstract: Mechanisms to persist object relations are provided. A project is defined as a series of interrelated objects having dependencies and relationships with one another. The dependencies and relationships are maintained via a storage organization for files that define the objects within a project storage environment for the project. Thus, the dependencies and relationships are not maintained via hardcoded instructions or references that are included within the files.

Abstract: Techniques for generic data access are provided. A middle-tier server agent uses data providers that can communicate with backend resources. A request received in a first format is used to identify a specific data provider by the middle-tier server agent; the data provider uses the first format to communicate with a specific backend resource in a second format. Results from the specific backend resource are returned from the data provider in the first format and passed to a client that initially made the request.

Abstract: Techniques for distributed cache management are provided. A server having backend resource includes a global cache and a global cache agent. Individual clients each have client cache agents and client caches. When data items associated with the backend resources are added, modified, or deleted in the client caches, the client cache agents report the changes to the global cache agent. The global cache agent records the changes and notifies the other client cache agents to update a status of the changes within their client caches. When the changes are committed to the backend resource each of the statuses in each of the caches are updated accordingly.

Abstract: Techniques for project management instantiation and configuration are provided. A master project includes policy directives that drive the dynamic instantiation and configuration of resources for a project. The resources are instantiated and configured on demand and when resources are actually requested, in response to the policy directives.

Abstract: Techniques for project lifecycle staged-based access control are provided. Access control rights are defined for a stage of a project's lifecycle. As requestors transition to the stage, the access control rights are enforced on top of any existing security restrictions. In an embodiment, selective resources are not visible to requesters within the stage in response to the access control rights.