Abstract: Novel devices for synthesizing ferrate and uses thereof are described. One aspect of the invention relates to devices and systems for synthesizing ferrate at a site proximal to the site of use.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: Techniques for generic data access are provided. A middle-tier server agent uses data providers that can communicate with backend resources. A request received in a first format is used to identify a specific data provider by the middle-tier server agent; the data provider uses the first format to communicate with a specific backend resource in a second format. Results from the specific backend resource are returned from the data provider in the first format and passed to a client that initially made the request.

Abstract: Mechanisms to support object-oriented version control operations are provided. A user manipulates and views a project from an object viewpoint and within an object module. The user performs version control operations using object handles. The object handles are resolved to specific file references and the specific file references are used to process legacy version control commands utilizing a legacy version control system in a manner that is transparent to the user.

Abstract: Techniques for project management instantiation and configuration are provided. A master project includes policy directives that drive the dynamic instantiation and configuration of resources for a project. The resources are instantiated and configured on demand and when resources are actually requested, in response to the policy directives.

Abstract: A method, system and medium are provided for enabling re-creation of a state of a computing system as it existed at a selected time. A plurality of data elements are tracked including functions and reference information employed in calculating one or more of the data elements. Versions of functions and reference information are also tracked. Thereby, a time at which to recreate the state of the system is selectable and the data elements that were available at or before the selected time are identifiable. And the versions of functions and reference information that were available at the selected time are identifiable. The state of the system at the selected time can thus be reviewed or analyzed as desired.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Techniques for project management instantiation and configuration are provided. A master project includes policy directives that drive the dynamic instantiation and configuration of resources for a project. The resources are instantiated and configured on demand and when resources are actually requested, in response to the policy directives.

Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Mechanisms to support multiple name space aware projects are provided. Multiple roots of a project declare multiple namespacing mechanisms. Resources of the project can utilize each of the multiple namespacing mechanisms. In some cases, a particular resource of the project can override and use a foreign namespace that is associated with a different project hierarchy even while that particular resource resides within a project hierarchy associated with the original project and even while the project hierarchy does not declare, at the root, the foreign namespace.

Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: A trench opener/closer is provided for an agricultural seeding machine movable in a planting direction. The trench opener/closer includes a disc opener assembly, a gauge wheel assembly, a closing assembly, a boot member, and a seed delivery member. The disc opener assembly has a first axis of rotation. The gauge wheel assembly has a second axis of rotation disposed rearward of the first axis of rotation in the planting direction. The closing assembly has a third axis of rotation disposed rearward of the second axis of rotation in the planting direction. The boot member extends between the disc opener assembly and the closing assembly. The seed delivery member is disposed rearward of the disc opener assembly in the planting direction. The seed delivery member is disposed adjacent to both a trailing edge of the boot member and the closing assembly.

Abstract: The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar?, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

Abstract: Mechanisms to support orphaned and partially configured objects are provided. A project includes a variety of objects. At least one object is designated as an orphaned object. The orphaned object lacks complete configuration details. Other objects of the project depend on the orphaned object and yet the other objects can load and process within the project as if the orphaned object was fully configured and available.

Abstract: The present invention concerns a compound of formula (I) or a salt, suitably a pharmaceutically acceptable salt, or solvate thereof, wherein the groups R1, R2, Ar?, A and Y are defined in the description, to compositions and use of the compounds in the treatment of inflammatory and allergic conditions.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: The present invention relates generally to systems, methods and software applications for storing, retrieving, and displaying information. More particularly, the present invention relates to providing a comprehensive, interactive tool for storing, retrieving, and displaying agent identifying information and agent commission information. The method of the present invention comprises the steps of: receiving agent identifying information and agent commission information; analyzing and sorting the received agent identifying information and agent commission information; saving the agent identifying information and the agent commission information; providing an interactive display of the agent identifying information and the agent commission information; providing interactive access to a display of detailed agent identifying information; and providing interactive access to a display of detailed agent commission information.

Abstract: Mechanisms to support fine-grain namespacing are provided. When an object is to be loaded within a processing environment, a specific namespace for that object is dynamically resolved during the load. That namespace can be dynamically resolved via object inheritance, via specific object-attribute declaration, and/or via consultation with a namespace object.

Abstract: Novel devices for synthesizing ferrate and uses thereof are described. One aspect of the invention relates to devices and systems for synthesizing ferrate at a site proximal to the site of use.