Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: A printing screen unit comprising a mesh printing screen and a supporting frame which is attached to the printing screen, wherein the printing screen comprises a first, outer mesh which is attached to sides of the supporting frame and includes an aperture therein, and a second, inner mesh which is attached to the outer mesh, wherein threads, providing warp and weft, of the outer mesh are aligned so as to be substantially orthogonal to the sides of the supporting frame, wherein threads, providing warp and weft, of the inner mesh being aligned so as to have acute angles of between 0 degrees and 45 degrees to the respective sides of the supporting frame, wherein the printing screen is tensioned by an external tensioning assembly to a first tension when the printing screen is attached to the supporting frame, and the sides of the supporting frame are displaceable such that the sides of the supporting frame are displaced on release of the first tension by the external tensioning assembly, and the printing screen h

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: An improved interface for managing disparate read, write, and erase sizes and operations in data storage devices is provided. By improving an interface between a storage system driver layer and associated storage devices, performance of data storage is improved, including improving data storage speed and storage media endurance. Storage media management operations are made more efficient and consistent by providing improved types and sequences of commands sent from the driver layer to the device control layer such that data write operations are performed in a sequential manner as write commands are directed to portions of data as opposed to buffering individual portions of data followed by a large wholescale write/erase process for the buffered data.

Abstract: A secondary indexing technique cooperates with primary indices of an indexing arrangement to enable efficient storage and access of metadata used to retrieve packets persistently stored in data files of a data repository. Efficient storage and access of the metadata used to retrieve the persistently stored packets may be based on a target value of the packets over a search time window. The metadata is illustratively organized as a metadata repository of primary index files that store the primary indices containing hash values of network flows of the packets, as well as offsets and paths to those packets stored in the data files. The technique includes one or more secondary indices having a plurality of present bits arranged in a binary format (i.e., a bit array) to indicate the presence of the target value in one or more packets stored in the data files over the search time window. Notably, the present bits may be used to reduce (i.e., “prune”) a relatively large search space of the stored packets (e.g.

Abstract: Compounds of Formula I: and pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 have the meanings as indicated in the specification, are useful for treating diseases mediated by blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

Abstract: Techniques for generic data access are provided. A middle-tier server agent uses data providers that can communicate with backend resources. A request received in a first format is used to identify a specific data provider by the middle-tier server agent; the data provider uses the first format to communicate with a specific backend resource in a second format. Results from the specific backend resource are returned from the data provider in the first format and passed to a client that initially made the request.

Abstract: Examples of determining the position of a mobile device within a structure are disclosed. In one example implementation according to aspects of the present disclosure, a computing device may include a processor and a memory. The computing device may further include an extraction module stored in the memory and executing on the processor to extract from a location-based service data stream a signal measurement of the path loss between a mobile device and a plurality of radio nodes distributed throughout a structure. The computing device may also include a positioning determining module stored in the memory and executing on the processor to determine the position of the mobile device within the structure using a known location for each of the plurality of radio nodes distributed throughout the structure by performing a linear optimization using the extracted signal measurement of the path loss.

Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: The present invention concerns a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, where R1-R3 and Y are defined in the description, and its use in the treatment of disorders in which pi3 kinase is implicated.

Abstract: Techniques managing complex dependencies in a file-based team environment are provided. A software module is represented as an object. The object is defined via a file. The file includes relationships, and some of the relationships define dependencies to other objects. In some cases, attributes for the object are also included in the file and are defined via references to still other objects. The relationships and the attributes are carried with the object via the file.

Abstract: The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.

Abstract: A processing technique provides an improved indexing arrangement that enables storage, filtering and querying of metadata used to retrieve packets captured from a network and persistently stored in a data repository. A packet capture engine records the packets in packet capture (PCAP) formats from a network link at a substantially high packet transfer rate to persistent storage of the data repository in a sustained manner. Efficient filtering and querying of the metadata to retrieve the stored packets may be achieved, in part, by organizing the metadata as one or more metadata repositories. The processing technique uses the Berkeley Packet Filter (BPF) language as an interface of a BPF engine to search or index the stored packets in response to queries. The BPF engine processes BPF expressions used as precursors to the indexing arrangement to enable access to the repositories when searching and locating stored packets matching the expressions.

Abstract: An improved method for purifying albumin, a variant or fragment thereof, a fusion protein comprising albumin, a variant or fragment thereof, or a conjugate comprising albumin, a variant or fragment thereof is disclosed.

Abstract: An apparatus comprises an adjustable locking plier body. A split jaw top is joined to the plier body. The split jaw top comprises a left jaw and a right jaw. The left jaw and the right jaw are separated by a distance. A bottom jaw is joined to the plier body. The bottom jaw is generally centered on the distance, wherein the bottom jaw and the split top jaw are operative for clamping a work piece inserted between the bottom jaw and the split jaw top.

Abstract: Examples of determining the position of a mobile device within a structure are disclosed. In one example implementation according to aspects of the present disclosure, a computing device may include a processor and a memory. The computing device may further include an extraction module stored in the memory and executing on the processor to extract from a location-based service data stream a signal measurement of the path loss between a mobile device and a plurality of radio nodes distributed throughout a structure. The computing device may also include a positioning determining module stored in the memory and executing on the processor to determine the position of the mobile device within the structure using a known location for each of the plurality of radio nodes distributed throughout the structure by performing a linear optimization using the extracted signal measurement of the path loss.

Abstract: A combustor for use in a gas turbine engine has a combustor outer shell. A panel has an inner face which will face hot products of combustion, and a boss surrounding a feature, with the boss extending to an outer end. A spacing surface is spaced from the boss, and is at an outer position that is inward of the outer end of the boss. The spacing surface spaces the panel from the outer shell. A trough is intermediate the boss and the spacing surface. The trough extends to an outer end which is inward of the outer position of the spacing surface. A gas turbine engine is also disclosed.

Abstract: The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.

Abstract: A system for collaborating on a component includes a computing device having a memory and a processor, the computing device configured to execute a first multi-user CAx environment, a data module configured to access data corresponding to a component design having at least one feature corresponding to a group of feature types from at least one current state database in a memory storage device, and a time stamp tool included in the multi-user CAx environment and configured to cause at least one computing device executing the multi-user CAx environment to apply a timestamp to each revision of a part model and save each revision including the timestamp to a revision database.

Abstract: A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.