Abstract: The present invention provides cell-targeting molecules which can deliver a CD8+ T-cell epitope cargo to the MHC class I presentation pathway of a target cell. The cell-targeting molecules of the invention can be used to deliver virtually any CD8+ T-cell epitope from an extracellular space to the MHC class I pathway of a target cell, which may be a malignant cell and/or non-immune cell. The target cell can then display on a cell-surface the delivered CD8+ T-cell epitope complexed with MHC I molecule. The cell-targeting molecules of the invention have uses which include the targeted labeling and/or killing of specific cell-types within a mixture of cell-types, including within a chordate, as well as the stimulation of beneficial immune responses. The cell-targeting molecules of the invention have uses, e.g., in the treatment of a variety of diseases, disorders, and conditions, including cancers, tumors, growth abnormalities, immune disorders, and microbial infections.

Abstract: A sporting field measurement system is disclosed wherein a user is prompted to select, on a mobile device, a field for marking from various sporting field types including, but not limited to football, baseball, softball, soccer, lacrosse, track, tennis, basketball, cricket, polo, rugby, Australian football, volleyball, and badminton. The Global National Satellite System (GNSS) or at least the global positioning system (GPS) is used to locate a user's device. An application displays, on a display, of the mobile device, the dimensions of the specified sporting field as an overlay on a map, generated by the positioning system and it will communicate with the GNSS or GPS of the device to allow the user to track his or her movement along a specified path of a proposed field. This will allow the user to place the appropriate markers and/or paint the field. Deviations from the path may be indicated on the display of the mobile device or by an audio indication generated by the mobile device.

Abstract: A method and processing system for assessing of the health of a network of retail locations in a defined geographic area, by a process including the development of a greenfield benchmark score for a network of ideally sited locations, followed by the development of a brownfield score of current locations, for comparison to the greenfield score. The invention is further applicable to decisions to open a new location, relocate an existing location or close an existing location. In these cases, the effect of opening a new location, or relocating or closing an underperforming location is evaluated by recalculating the brownfield score after the addition of each of several potential new locations, and/or after relocating or closing each of several poorly performing locations.

Abstract: An ultrasound probe includes an ultrasound probe housing (36) and one or more ultrasound transducers (32) disposed in the ultrasound probe housing. A dosimeter (40) or ionizing radiation detector is disposed in or attached to the ultrasound probe housing. An alarm device (24, 52, 54, 56) receives radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector. The alarm device includes an electronic processor (24, 56) programmed to detect excessive radiation dose or radiation exposure received by the ultrasound probe based on the radiation dose or radiation exposure data acquired by the dosimeter or ionizing radiation detector, and output an alarm warning of the detection of excessive radiation dose or radiation exposure received by the ultrasound probe. In some embodiments, the dosimeter is a one-time use dosimeter that is not resettable.

Abstract: A heating device for a rear wall of a tumble dryer is disclosed, wherein the heating device includes an electric heating arrangement which may be formed of heating coils. A bypass airflow which is not directly heated by the heating arrangement flows in addition in the housing so that the heat loss through the housing is reduced.

Abstract: The present invention relates to an ultrasound imaging system comprising an ultrasound probe having a transducer array configured to provide an ultrasound receive signal. The system further comprises a B-mode volume processing unit configured to generate a B-mode volume based on the ultrasound receive signal, and a B-mode image processing unit configured to provide a current B-mode image based on the B-mode volume. The system further comprises a memory configured to store a previously acquired 3D-vessel map. Also, the system comprises a registration unit configured to register the previously acquired 3D-vessel map to the B-mode volume and to select a portion of the 3D-vessel map corresponding to the current B-mode image. Further, the system comprises a display configured to display an ultrasound image based on the current B-mode image and the selected portion of the 3D-vessel map.

Abstract: A sporting field measurement system is disclosed wherein a user is prompted to select, on a mobile device, a field for marking from various sporting field types including, but not limited to football, baseball, softball, soccer, lacrosse, track, tennis, basketball, cricket, polo, rugby, Australian football, volleyball, and badminton. The Global National Satellite System (GNSS) or at least the global positioning system (GPS) is used to locate a user's device. An application displays, on a display, of the mobile device, the dimensions of the specified sporting field as an overlay on a map, generated by the positioning system and it will communicate with the GNSS or GPS of the device to allow the user to track his or her movement along a specified path of a proposed field. This will allow the user to place the appropriate markers and/or paint the field. Deviations from the path may be indicated on the display of the mobile device or by an audio indication generated by the mobile device.

Abstract: A matrix array probe including a transducer array and integrated circuitry coupled to the transducer elements dissipates heat generated by the array and integrated circuitry through the cover of the transducer probe. A pump in the probe connector pumps fluid through a closed loop system including inbound an outbound fluid conduits in the cable. The fluid conduits in the cable are separated by the cable electrical conductors for the probe. The heat transfer in the probe is done by a heat exchanger in the transducer backing block. Additional cooling may be provided by metal to metal contact with a chiller in the ultrasound system.

Abstract: The present invention relates to an ultrasound imaging system (10) comprising an ultrasound probe (20) having a transducer array (21) configured to provide an ultrasound receive signal. The system further comprises a B-mode volume processing unit (30) configured to generate a B-mode volume (31) based on the ultrasound receive signal, and a B-mode image processing unit (40) configured to provide a current B-mode image (41) based on the B-mode volume (31). The system further comprises a memory (50) configured to store a previously acquired 3D-vessel map (51). Also, the system comprises a registration unit (60) configured to register the previously acquired 3D-vessel map (51) to the B-mode volume (31) and to select a portion (61) of the 3D-vessel map corresponding to the current B-mode image (41). Further, the system comprises a display configured to display an ultrasound image (71) based on the current B-mode image (41) and the selected portion (61) of the 3D-vessel map (51).

Abstract: An ultrasound system includes a 3D imaging probe and a needle guide which attaches to the probe for guidance of the insertion of multiple needles into a volumetric region which can be scanned by the 3D imaging probe. The needle guide responds to the insertion of a needle through the guide by identifying a plane for scanning by the probe which is the insertion plane through which the needle will pass during insertion. The orientation of the insertion plane is communicated to the probe to cause the probe to scan the identified plane and produce images of the needle as it travels through the insertion plane.

Abstract: The present invention relates to a pre-collapsed capacitive micro-machined transducer cell (10) comprising a substrate (12) comprising a first electrode (16), a membrane (14) comprising a second electrode (18), wherein the cell has an outer region (22) where the membrane (14) is mounted to the substrate (12) and an inner region (20) inside or surrounded by the outer region (22), wherein the membrane (14) is collapsed to the substrate (12) in a first collapsed annular-shaped region (24) located within the inner region (20).

Abstract: The present invention relates to Shiga toxin A Subunit derived polypeptides and cell-targeting molecules comprising amino acid substitutions which equip the polypeptides with 1) de-immunization; 2) reduced, protease-cleavage sensitivity; and/or 3) a heterologous epitope cargo(s) while retaining Shiga toxin function(s), such as, e.g., potent cytotoxicity. Certain polypeptides of the invention exhibit reduced immunogenic potential in mammals and/or are capable of delivering an epitope to an MHC class molecule of a cell in which the polypeptide is present. Certain molecules comprising a polypeptide of the invention are well-tolerated by mammals while retaining one or more of the features mentioned above.

Abstract: A matrix array probe including a transducer array and integrated circuitry coupled to the transducer elements dissipates heat generated by the array and integrated circuitry through the cover of the transducer probe. A pump in the probe connector pumps fluid through a closed loop system including inbound an outbound fluid conduits in the cable. The fluid conduits in the cable are separated by the cable electrical conductors for the probe. The heat transfer in the probe is done by a heat exchanger in the transducer backing block. Additional cooling may be provided by metal to metal contact with a chiller in the ultrasound system.

Abstract: In an embodiment of the present invention, a production light is provided to be attached to the bottom of a camera, via a threaded aperture, typically used to mount a camera to a tripod. The production light is configured to emit light about a 360-degree angle via a light emitting diode (LED) array.

Abstract: A matrix array probe including a transducer array and integrated circuitry coupled to the transducer elements dissipates heat generated by the array and integrated circuitry through the cover of the transducer probe. A pump in the probe connector pumps fluid through a closed loop system including inbound an outbound fluid conduits in the cable. The fluid conduits in the cable are separated by the cable electrical conductors for the probe. The heat transfer in the probe is done by a heat exchanger in the transducer backing block. Additional cooling may be provided by metal to metal contact with a chiller in the ultrasound system.

Abstract: A matrix array probe including a transducer array and integrated circuitry coupled to the transducer elements dissipates heat generated by the array and integrated circuitry through the cover of the transducer probe. A pump in the probe connector pumps fluid through a closed loop system including inbound an outbound fluid conduits in the cable. The fluid conduits in the cable are separated by the cable electrical conductors for the probe. The heat transfer in the probe is done by a heat exchanger in the probe spaceframe or transducer stack backing block and may use a Peltier device. Additional cooling may be provided by metal to metal contact with a chiller in the ultrasound system.

Abstract: The present invention relates to a pre-collapsed capacitive micro-machined transducer cell (10) comprising a substrate (12) comprising a first electrode (16), a membrane (14) comprising a second electrode (18), wherein the cell has an outer region (22) where the membrane (14) is mounted to the substrate (12) and an inner region (20) inside or surrounded by the outer region (22), wherein the membrane (14) is collapsed to the substrate (12) in a first collapsed annular-shaped region (24) located within the inner region (20).

Abstract: The present invention relates to an ultrasound imaging system (10) comprising an ultrasound probe (20) having a transducer array (21) configured to provide an ultrasound receive signal. The system further comprises a B-mode volume processing unit (30) configured to generate a B-mode volume (31) based on the ultrasound receive signal, and a B-mode image processing unit (40) configured to provide a current B-mode image (41) based on the B-mode volume (31). The system further comprises a memory (50) configured to store a previously acquired 3D-vessel map (51). Also, the system comprises a registration unit (60) configured to register the previously acquired 3D-vessel map (51) to the B-mode volume (31) and to select a portion (61) of the 3D-vessel map corresponding to the current B-mode image (41). Further, the system comprises a display configured to display an ultrasound image (71) based on the current B-mode image (41) and the selected portion (61) of the 3D-vessel map (51).