Abstract: A method, apparatus, device, and computer readable storage medium for recognizing and decoding a voice based on a streaming attention model are provided. The method may include generating a plurality of acoustic paths for decoding the voice using the streaming attention model, and then merging acoustic paths with identical last syllables of the plurality of acoustic paths to obtain a plurality of merged acoustic paths. The method may further include selecting a preset number of acoustic paths from the plurality of merged acoustic paths as retained candidate acoustic paths. Embodiments of the present disclosure present a concept that acoustic score calculating of a current voice fragment is only affected by its last voice fragment and has nothing to do with earlier voice history, and merge acoustic paths with the identical last syllables of the plurality of candidate acoustic paths.

Abstract: The disclosure provides a method, an apparatus, a device, and a computer-readable storage medium for speech synthesis in parallel. The method includes: splitting a piece of text into a plurality of segments; based on the piece of text, obtaining a plurality of initial hidden states of the plurality of segments for a recurrent neural network. The method further includes: synthesizing the plurality of segments in parallel based on the plurality of initial hidden states and input features of the plurality of segments.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: Methods, apparatuses, devices and computer-readable storage media for real-time speech recognition are provided. The method includes: based on an input speech signal, obtaining truncating information for truncating a sequence of features of the speech signal; based on the truncating information, truncating the sequence of features into a plurality of subsequences; and for each subsequence in the plurality of subsequences, obtaining a real-time recognition result through attention mechanism.

Abstract: The present patent application discloses at least the compounds according to Formula I? shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, JB, n, JD, J, X, Z, Z1, RC1, RC2, Y, R9, o and W are as defined herein.

Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: Methods, apparatuses, devices and computer-readable storage media for real-time speech recognition are provided. The method includes: based on an input speech signal, obtaining truncating information for truncating a sequence of features of the speech signal; based on the truncating information, truncating the sequence of features into a plurality of subsequences; and for each subsequence in the plurality of subsequences, obtaining a real-time recognition result through attention mechanism.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).

Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable.

Abstract: Disclosed is a voiceprint login method based on artificial intelligence. The method includes: S1: receiving a login request from a user and acquiring user information of the user; S2: generating a login string and replacing at least one character of the login string according to character replacement reference information corresponding to the user information; S3: providing the login string after replacement to the user and receiving speech information of the user reading the login string; and S4: performing a login authentication on the user according to speech information of the user reading the login string. With the method, by using the voiceprint authentication method combining the voiceprint and the character replacement reference information set by the user, the safety of the voiceprint password is increased, and some characters are hidden according the user's preferences, which satisfies the user's psychological demand of not wishing the password to be displayed explicitly.

Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

Abstract: A silencing device, an air purifier, and a method for producing the same are provided. The method includes that: a sound wave spectrum when an air purifier to be silenced performs operations is acquired; a frequency value, which exceeds a sound wave frequency limit for the air purifier, of the sound wave spectrum is calculated; and a silencing device adapted to the air purifier to be silenced is produced according to the frequency value. At least one structural parameter of the silencing device is configured according to the frequency value. The silencing device is configured to reduce a sound with the frequency value exceeding the sound wave frequency limit.

Abstract: Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Abstract: A network device for implementing voice input comprises an input-obtaining module for obtaining voice input information, a sequence-determining module for determining an input character sequence corresponding to the voice input information based on a voice recognition model, an accuracy-determining module for determining appearance-probability information corresponding to word segments in the input character sequence so as to obtain accuracy information of the word segments, and a transmitting module for transmitting, to a user device, the input character sequence and the accuracy information of the word segments corresponding to the voice input information.

Abstract: Single chain antibody polypeptides with engineered peptide bond crossovers in the light chain and/or heavy chain variable domains, compositions comprising the same, and methods of making and using the same are provided. The antibody polypeptides can be intercalated (crossover) single chain variable fragments (scFvs) or any antibody frameworks which comprise such scFvs, such as diabodies, bispecific antibodies or bssFvs. The single chain antibody polypeptides may or may not contain a linker. The single chain antibody polypeptides are useful in applications where standard (conventional) scFvs are useful, such as in the development of scFv libraries for screening, as therapeutic antibodies, or in in vitro and in vivo targeting applications.