Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: The disclosure provides a method, an apparatus, a device, and a computer-readable storage medium for speech synthesis in parallel. The method includes: splitting a piece of text into a plurality of segments; based on the piece of text, obtaining a plurality of initial hidden states of the plurality of segments for a recurrent neural network. The method further includes: synthesizing the plurality of segments in parallel based on the plurality of initial hidden states and input features of the plurality of segments.

Abstract: The present application discloses a voice processing system and method, an electronic device and a readable storage medium, which relates to the field of voice processing technologies. The voice processing system includes: a neural-network processing unit (NPU) and an RISC-V processor; wherein the RISC-V processor includes predefined NPU instructions, and the RISC-V processor is configured to send the NPU instructions to the NPU to cause the NPU to perform corresponding neural network computation; the NPU includes a memory unit and a computing unit, and the memory unit includes a plurality of storage groups; the computing unit is configured to execute one of main computation, special computation, auxiliary computation and complex instruction set computing (CISC) control according to the received NPU instructions.

Abstract: Compounds of formula (I): (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: A method of registering an attribute in a speech synthesis model, an apparatus of registering an attribute in a speech synthesis model, an electronic device, and a medium are provided, which relate to a field of an artificial intelligence technology such as a deep learning and intelligent speech technology. The method includes: acquiring a plurality of data associated with an attribute to be registered; and registering the attribute in the speech synthesis model by using the plurality of data associated with the attribute, wherein the speech synthesis model is trained in advance by using a training data in a training data set.

Abstract: The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: A method, apparatus, device, and storage medium for voice interaction. A specific embodiment of the method includes: extracting an acoustic feature from received voice data, the acoustic feature indicating a short-term amplitude spectrum characteristic of the voice data; applying the acoustic feature to a type recognition model to determine an intention type of the voice data, the intention type being one of an interaction intention type and a non-interaction intention type, and the type recognition model being constructed based on the acoustic feature of training voice data; and performing an interaction operation indicated by the voice data, based on determining that the intention type is the interaction intention type.

Abstract: The present disclosure provides a speech processing method, and a method for generating a speech processing model, related to a field of signal processing technologies. The speech processing method includes: obtaining M speech signals to be processed and N reference signals; performing sub-band decomposition on each of the M speech signals and each of the N reference signals to obtain frequency-band components in each speech signal and each reference signal; processing the frequency-band components in each speech signal and each reference signal by using an echo cancellation model, to obtain an ideal ratio mask corresponding to the N reference signals in each frequency band of each speech signal; and performing echo cancellation on each frequency-band component of each speech signal based on the ideal ratio mask corresponding to the N reference signals in each frequency band of each speech signal, to obtain M echo-cancelled speech signals.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable.

Abstract: The present disclosure provides a method and apparatus of synthesizing a speech, a method and apparatus of training a speech synthesis model, an electronic device, and a storage medium. The method of synthesizing a speech includes acquiring a style information of a speech to be synthesized, a tone information of the speech to be synthesized, and a content information of a text to be processed; generating an acoustic feature information of the text to be processed, by using a pre-trained speech synthesis model, based on the style information, the tone information, and the content information of the text to be processed; and synthesizing the speech for the text to be processed, based on the acoustic feature information of the text to be processed.

Abstract: The present invention relates to chemical compounds having a general formula (I), as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Abstract: The present disclosure discloses a control method and a control apparatus for speech interaction. The detailed implementation solution of the control method for the speech interaction includes: collecting an audio signal; detecting a wake-up word in the audio signal to obtain a wake-up word result; and playing a prompt tone and/or executing a speech instruction in the audio signal based on the wake-up word result.

Abstract: The present disclosure discloses a control method and a control apparatus for speech interaction. The detailed implementation solution of the control method for the speech interaction includes: collecting an audio signal; detecting a wake-up word in the audio signal to obtain a wake-up word result; and playing a prompt tone and/or executing a speech instruction in the audio signal based on the wake-up word result.

Abstract: Compounds of Formulae I? and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed.

Abstract: A silencing device, an air purifier, and a method for producing the same are provided. The method includes that: a sound wave spectrum when an air purifier to be silenced performs operations is acquired; a frequency value, which exceeds a sound wave frequency limit for the air purifier, of the sound wave spectrum is calculated; and a silencing device adapted to the air purifier to be silenced is produced according to the frequency value. At least one structural parameter of the silencing device is configured according to the frequency value. The silencing device is configured to reduce a sound with the frequency value exceeding the sound wave frequency limit.

Abstract: Embodiments of the present disclosure provide a thin film transistor assembly, an array substrate and a display panel. The thin film transistor assembly includes a first thin film transistor and a second thin film transistor disposed on a substrate. The first thin film transistor includes a first source electrode, a first drain electrode, and a first active layer. The second thin film transistor includes a second source electrode. The first source electrode is disposed on a side of the first active layer facing towards the substrate. The first drain electrode is disposed on a side of the first active layer facing away from the substrate. An orthogonal projection of the first source electrode on the substrate overlaps an orthogonal projection of the second source electrode on the substrate.

Abstract: The present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) and/or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP) might be desirable. Various compounds are disclosed, including those of Formula (I).

Abstract: Embodiments of the present disclosure provide a method and apparatus for voice identification, a device and a computer readable storage medium. The method may include: for an inputted voice signal, obtaining a first piece of decoded acoustic information by a first acoustic model and obtaining a second piece of decoded acoustic information by a second acoustic model, where the second acoustic model being generated by joint modeling of acoustic model and language model. The method may further include determining a first group of candidate identification results based on the first piece of decoded acoustic information, determining a second group of candidate identification results based on the second piece of decoded acoustic information, and then determining a final identification result for the voice signal based on the first group of candidate identification results and the second group of candidate identification results.

Abstract: A voice response method, apparatus and intelligent device are disclosed. The method includes: receiving voice information sent by a user; determining whether the voice information contains a wake-up word; and if so, outputting a response voice according to a preset response rule. Thus, if there is a wake-up word in voice information received by the intelligent device, the intelligent device outputs a response voice according to a preset response rule. That is, after the user sends a wake-up word, the intelligent device outputs a voice to respond to the wake-up word. Therefore, the user can directly determine that the device has been woken up and can have a better experience.

Abstract: Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.