Abstract: Provided are a human PD-1 knockdown siRNA, a recombinant expression CAR-T vector, a preparation method thereof, and an application of the same. A PD-1 knockdown siRNA expression cassette and an siRNA expression product thereof can be applied to a CAR-T therapy of multiple myeloma (MM) for eliminating or alleviating a tumor immune escape mechanism, and in the suppression of an immune escape mechanism in a CAR-T therapy of a tumor, such as pancreatic cancer, brain glioma, and myeloma.

Abstract: Aspects of the invention include constructing a knowledge graph by writing a plurality of data structures to connect correlated log messages in a system log. Detecting an anomalous log message based on the knowledge graph, wherein the anomalous log message is connected to a plurality of candidate root cause error log messages. Determining respective sequences from each of the plurality of candidate root cause error log messages to the anomalous log message. Calculating a deviation score for each respective sequence based on a deviation of an expected sequence for each candidate root cause error log message and the determined sequence. Determining a root cause log error message based on the calculated deviation scores.

Abstract: A piping assembly and a refrigeration system. The piping assembly includes: an inlet portion extending along an inlet axis; an outlet portion extending along an outlet axis, wherein a predetermined angle is formed between the inlet axis and the outlet axis; a transition portion being attached between the inlet portion and the outlet portion and defining a transition axis; a cavity extending from the inlet portion to the outlet portion through the transition portion; and a first straightening portion including a plurality of deflector plates attached to an inner wall of the cavity, wherein the first straightening portion includes at least a first deflector plate and a second deflector plate connected at an angle, and the first deflector plate and the second deflector plate are configured to extend in parallel with a part of the outlet axis and a part of the transition axis.

Abstract: A client computer may split a process into sub-processes, send each sub-processes to a different group of peers in a blockchain network, wherein each group has at least one peer from each essential organization in the blockchain network, receive processed sub-transactions from the peers in the blockchain network, validate each sub-transaction, and validate the transaction based on the validation of all sub-transactions, wherein all sub-transaction must be valid for the transaction to be valid.

Abstract: Methods of treating disease include measuring a CCR2 profile of a patent, selecting a CCR2 antagonist based on the CCR2 profile of the patient, and administering the CCR2 antagonist to the patient. Methods for stratifying one or more patients for pain medication based on a CCR2 profile include measuring a CCR2 profile of one or more patients and partitioning the one or more patients into predetermined groups or subgroups based on the CCR2 profile of the one or more patients. Kits for performing the methods are also described.

Abstract: The present disclosure provides a semiconductor device comprising a substrate; a first III-V compound layer over the substrate; a second III-V compound layer on the first III-V compound layer; a third III-V compound layer on the second III-V compound layer; a source region on the third III-V compound layer; a drain region on the third III-V compound layer; a first dielectric layer arranged on the second III-V compound layer through the third III-V compound layer; and a gate region on the first dielectric layer, wherein a bottom of the gate region is higher than a top surface of the first dielectric layer; the second lateral distance is larger than the first lateral distance.

Abstract: The present invention provides methods, devices and systems for sequencing and/or analyzing a polymer and/or polymer unit. The polymer may include but not limited to DNA, RNA, a polysaccharide, or a protein. The device includes a nano-pen, which is a bifunctional nanopore/nanoelectrode, and a second electrode. The nano-pen electrode and the second electrode form a tunnel gap. Polymers passing through the nano-pen nanopore will be directed to the tunnel gap between electrodes. The electrodes are functionalized with a recognition reagent, and the reagent can transiently bind each polymer unit during its passage. When the transient bond forms, distinctive current signals are detected and recorded. The signals are utilized to analyze and identify the polymer and/or polymer unit.

Abstract: In accordance with an embodiment of the invention, a method is provided for performing data pre-processing operations during data preparation of a machine learning lifecycle. The method includes defining one or more data pre-processing functions for applying to data stored in a dataset, executing one or more learn functions for learning the data, and executing one or more transform functions for transforming the data. Each of the one or more learn functions generates a first Structured Query Language (SQL) statement representing a definition of corresponding learn function for corresponding defined data pre-processing function. Each of the one or more transform functions generates a second SQL statement representing a definition of corresponding transform function for corresponding defined data pre-processing function. The dataset is stored in a database.

Abstract: Techniques for refinement of data pipelines are provided. An original file of serialized objects is received, and an original pipeline comprising a plurality of transformations is identified based on the original file. A first computing cost is determined for a first transformation of the plurality of transformations. The first transformation is modified using a predefined optimization, and a second cost of the modified first transformation is determined. Upon determining that the second cost is lower than the first cost, the first transformation is replaced, in the original pipeline, with the optimized first transformation.

Abstract: A computer-implemented method for providing a personalized user interface to a user may include obtaining customer data; obtaining customer article data; obtaining customer interface activity data of the at least one customer; training a prediction model; obtaining at least one of user data, user article data, or user interface activity data of a user of the apparel subscription application; determining a rank of one or more articles based on the prediction model; obtaining environmental data including values of one or more environmental factors associated with user article data; and providing, to the user, the personalized user interface associated with the apparel subscription application to the user based on the rank of the one or more articles and the environmental data.

Abstract: An electronic device is provided, including a display panel and a processor. The display panel is configured to display image data and includes a backlight module, and the processor is electrically connected to the display panel. The processor averages current values of the backlight module corresponding to the image data in a first time period, to generate an average current value, and compares the average current value with a current threshold. When the average current value is greater than the current threshold, the processor generates an adjusted maximum current value, and correspondingly reduces current values of the backlight module in a second time period according to the adjusted maximum current value, to reduce a temperature of the electronic device. A temperature adjustment method of an electronic device is also provided.

Abstract: An electronic device is provided in this disclosure. The electronic device includes a display panel and a processor. The processor is electrically connected to the display panel. The processor receives image data and calculates a display area occupied by the image data on the display panel according to the image data. Then, the processor adjusts a backlight current value of the display panel according to the display area and an area-current relationship, to adjust the brightness of the display panel. In this way, the brightness of the display panel is consistent when the display panel displays images of different areas. The disclosure also provides a brightness adjustment method of an electronic device.

Abstract: The present invention relates to technical field of communications and provides a method and a device for site selection for a monitoring station. The method comprises acquiring a site list comprising multiple relay stations and a connection relationship of optical cables among the relay stations; sequentially setting each relay station to be a starting site, and traversing the relay stations in the site list according to a preset coverage range from the starting site, and determining a set of uncovered relay stations corresponding to each starting site; according to a preset intersection base, traversing the set of relay stations that cannot be covered corresponding to each starting site to get an intersection, and determining one or more relay stations corresponding to a set of whose intersection result is empty as a target monitoring station. The method improves efficiency and accuracy of site selections and has wide applicability.

Abstract: An example operation may include one or more of generating a blockchain request which comprises data for a blockchain, creating a tag value which identifies whether the blockchain request is a noisy request that comprises fake data or a non-noisy request that comprises non-noisy data, storing the tag value within the blockchain request, and transmitting the blockchain request to one or more blockchain peers.

Abstract: A piston pump includes a housing, a driving assembly, a pump, and a nozzle assembly. The housing includes upper and lower brackets. The driving assembly is in the housing and includes a gear motor and a piston. The pump includes a pump body in the housing, a pressing plate with one end of the piston extending into the pump body, and a pressing membrane on the piston for sealing a space between the pump body and the piston; the pump body cooperates with the housing to position the pressing membrane; an intermediate portion of the pressing membrane reciprocates as the piston repeatedly moves back and forth; the pump further comprises a pushing member in the pump body for sealing the pump body; and one end of the pushing member extends into the piston. The nozzle assembly includes a nozzle and a nozzle seat disposed in the pump body.

Abstract: The invention provides a manufacturing method for flexible display panel, comprising providing an array substrate, the array substrate comprising a semiconductor layer, dividing the flexible display panel into a pixel area and a bending area, adjacent to each other, the pixel area comprising the semiconductor layer; disposing a second groove in the bending area, and the second groove forming a step structure in the array substrate, the step structure extending from inside of the array substrate towards direction opposite to inner wall of the second groove; filling the second groove with an organic material, and the organic material filling the second groove forming a concave tapered groove with flat surface of the array substrate; fabricating a source, a drain, and source/drain wiring on the array substrate, the source and the drain being connected to the semiconductor layer, the source/drain wiring covering the tapered groove.

Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

Abstract: An OCTS-based CAR-T vector for treating pancreatic cancer and malignant mesothelioma includes lentiviral skeleton plasmid, human EF1? promoter (SEQ ID NO: 14), OCTS chimeric receptor structural domain, and PDL1 single-chain antibody; the OCTS chimeric receptor structural domain consists of CD8 leader chimeric receptor signal peptide (SEQ ID NO: 15), PDL1 single-chain antibody light chain VL (SEQ ID NO: 16), PDL1 single-chain antibody heavy chain VH (SEQ ID NO: 17), mesothelin single-chain antibody light chain VL (SEQ ID NO: 18), mesothelin single-chain antibody heavy chain VH (SEQ ID NO: 19), antibody Inner-Linker (SEQ ID NO: 20), single-chain antibody Inter-Linker (SEQ ID NO: 21), CD8 Hinge chimeric receptor linker (SEQ ID NO: 22), CD8 Transmembrane chimeric receptor transmembrane domain (SEQ ID NO: 23), TCR chimeric receptor T cell activation domain (SEQ ID NO: 26) and chimeric receptor co-stimulator domain.