Abstract: Described herein are compounds and pharmaceutical compositions of phenyl-pyrimidinyl-urea derivatives, which inhibit the activity of Olig2. An example of a phenyl-pyrimidinyl-urea derivative has the following structure: Also described herein are methods using the Olig2 inhibitors for treating cancer and other diseases. The Olig2 inhibitors may be used to treat glioblastoma.

Abstract: The present disclosure provides microRNA-based therapies using a hydrogel delivery system that provides regenerative approach to myocardial infarction by targeting cardiomyocytes. The hydrogel provides for local and sustained cardiac delivery of microRNAs, such miR-302 mimics that can be used to promote cardiomyocyte proliferation. Also provided are compositions suitable for local and sustained release and methods for intramyocardial gel delivery of a miRNA oligonucleotide.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are urea compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Disclosed are methods of in situ genomic modification of cells (e.g., stem cells, tissue stem cells, muscle stem cells, Sca-V mesenchymal progenitor cells in skeletal muscle, CD140a+ dermal mesenchymal cells) using sequence-targeting nucleases delivered via a virus (e.g., an AAV).

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: Known lipid molecules of a matrix are grouped into lipid classes and the lipid classes are further grouped into a pass-through group and a mobility separation group based on isobaric interferences. A separation system separates known lipid molecules from a matrix sample and an ion source ionizes the matrix sample. Two injections are performed. For the first injection a DMS device is put into passive mode, and for the second injection the DMS device is used to resolve isobaric interferences. A tandem mass spectrometer performs MRM scans of the pass-through group for the first injection and MRM scans of the mobility separation group for the second injection. A processor quantitates each lipid molecule in the matrix sample by comparing the MRM intensity values obtained for the first and second injections to MRM intensity and concentration values for known standards of the known lipid molecules of the matrix.

Abstract: Disclosed are methods of modifying the genome of HSPCs in vivo by introducing an AAV into a subject transducing a sequence targeting nuclease. In some aspects, the method can be utilized to ascertain causal links between CHIP mutations and age-associated disease. In other aspects, the method can be utilized to treat Sickle cell disease (SCD) and ?-thalassemia.

Abstract: Systems and methods for collecting weather information for selected airspace regions are provided. In one embodiment, a method for collecting weather information for selected airspace regions comprises: receiving aircraft position information for a plurality of aircraft; forming an aircraft weather group based on flight path attributes derived from the aircraft position information; selecting at least a first representative aircraft from the weather group; and receiving at a weather information ground station, weather data from one or more representative aircraft of the aircraft weather group, wherein only the one or more representative aircraft transmit weather information to the weather information ground station from the aircraft weather group.

Abstract: Systems and methods for collecting weather information for selected airspace regions are provided. In one embodiment, a method for collecting weather information for selected airspace regions comprises: receiving aircraft position information for a plurality of aircraft; forming an aircraft weather group based on flight path attributes derived from the aircraft position information; selecting at least a first representative aircraft from the weather group; and receiving at a weather information ground station, weather data from one or more representative aircraft of the aircraft weather group, wherein only the one or more representative aircraft transmit weather information to the weather information ground station from the aircraft weather group.

Abstract: The present disclosure provides microRNA-based therapies using a hydrogel delivery system that provides regenerative approach to myocardial infarction by targeting cardiomyocytes. The hydrogel provides for local and sustained cardiac delivery of microRNAs, such miR-302 mimics that can be used to promote cardiomyocyte proliferation. Also provided are compositions suitable for local and sustained release and methods for intramyocardial gel delivery of a miRNA oligonucleotide.

Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.

Abstract: A self-contained breathing apparatus. The self-contained breathing apparatus comprises a back plate comprising a shoulder strap load portion and a waist belt load portion, wherein the waist belt load portion rotates about an extended axis defined by the junction of the waist belt load portion with the shoulder strap load portion, a shoulder strap coupled to the shoulder strap load portion of the back plate, a waist belt coupled to the waist belt load portion of the back plate, and a bottle of compressed breathable air secured to the shoulder strap load portion of the back plate.

Abstract: Systems and methods for collecting weather information for selected airspace regions are provided. In one embodiment, a method for collecting weather information for selected airspace regions comprises: receiving aircraft position information for a plurality of aircraft; forming an aircraft weather group based on flight path attributes derived from the aircraft position information; selecting at least a first representative aircraft from the weather group; and receiving at a weather information ground station, weather data from one or more representative aircraft of the aircraft weather group, wherein only the one or more representative aircraft transmit weather information to the weather information ground station from the aircraft weather group.

Abstract: Systems and methods for collecting weather information for selected airspace regions are provided. In one embodiment, a method for collecting weather information for selected airspace regions comprises: receiving aircraft position information for a plurality of aircraft; forming an aircraft weather group based on flight path attributes derived from the aircraft position information; selecting at least a first representative aircraft from the weather group; and receiving at a weather information ground station, weather data from one or more representative aircraft of the aircraft weather group, wherein only the one or more representative aircraft transmit weather information to the weather information ground station from the aircraft weather group.