Abstract: Example embodiments relate generally to data resynchronization methods and systems in continuous data protection (CDP) and more specifically to an input and output (I/O) filtering framework and log management system to seek a near-zero recovery point objective (RPO).

Abstract: A substrate includes a first base, a first trace, a first organic layer, a first inorganic layer, and a second trace. The first organic layer includes at least one first via hole, and a first via hole exposes a portion of the first trace. The first inorganic layer includes at least one second via hole. On the first base, an orthographic projection of an edge of an opening of a second via hole proximate to the first via hole is substantially coincident with an orthographic projection of an edge of an opening of the first via hole proximate to the second via hole. The first and second via holes are communicated to form a connecting hole to connect the first and second traces. A ratio of a depth of the connecting hole to a maximum radial dimension of the connecting hole ranges from 1:1 to 1:2, inclusive.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents such as siRNAs, able to Inhibin Subunit Beta E (INHBE) gene expression. Also disclosed are pharmaceutical compositions that include INHBE RNAi agents and methods of use thereof. The INHBE RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the INHBE RNAi agents in vivo provides for inhibition of INHBE gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by INHBE gene expression, such as obesity, diabetes, liver inflammation, dyslipidemia, or metabolic disease.

Abstract: Provided is a catenated VAR2CSA recombinant protein, a preparation therefor and a use thereof. The catenated VAR2CSA recombinant protein comprises a binding domain, SpyTag, a p53dim structural domain, and SpyCatcher, which are randomly arranged. The binding domain comprises a structural domain, in the VAR2CSA protein, binding to placenta-like chondroitin sulfate A. The catenated VAR2CSA recombinant protein has high stability and affinity to the tumor-specific antigen placenta-like chondroitin sulfate A, and can be effectively used in the field of tumor immunotherapy, such as immune cell therapy.

Abstract: Various embodiments of a method and apparatus for determining parametric timing yield and bottlenecks are disclosed which take into account correlation between electrical circuit paths through common timing arcs of an integrated circuit chip under design. Monte Carlo samples of timing arc delays are generated and used in computing timing yield and identify yield bottlenecks.

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract: A rail train is provided in the embodiment of the present disclosure, comprising: a semi-enclosed air duct, the semi-enclosed air duct comprises an air duct top and an air duct side; the air duct top is fixed with an inner top of a rail train body, the air duct side is connected on both sides of the air duct top and extends downward; a large side top, and the the large side top is fixed to the rail train body as a part of a rail train roof, and the large side top is top-sealed at a bottom of the air duct side to form an air passage with the air duct. The rail train solves the technical problem that the roof and the air duct of the rail train are not conducive to overall weight reduction of the rail train.

Abstract: Provided is a hypochlorous acid disinfection water machine. The hypochlorous acid disinfection water machine includes a water inlet pipeline; a primary electrolyte cell, which is internally provided with a cation exchange membrane, and the outlet end of the water inlet pipeline communicates with the primary electrolyte cell; and a secondary electrolyte cell, which is a non-membrane electrolytic cell, a primary hypochlorous acid solution in an anode chamber of the primary electrolyte cell communicates with the secondary electrolyte cell, the primary hypochlorous acid solution in the anode chamber of the primary electrolyte cell is electrolyzed again in the secondary electrolyte cell to obtain a secondary hypochlorous acid solution. The hypochlorous acid disinfection water machine provided by the disclosure may solve the problem of poor concentration stability of a hypochlorous acid disinfection water machine in the relevant art.

Abstract: A storage cluster may dynamically select a data transport mode for supporting a backup or export job. The storage cluster may receive a trigger indication to create, a backup of data of a source virtual machine. The storage cluster may select a data transport mode to use for reading the data from the source virtual machine to create the backup at the storage cluster. The selection may be from a set of data transport modes that includes a proxy virtual machine mode and a direct-to-host mode. The storage cluster may transmit, to a host for the source virtual machine, a request to activate the selected data transport mode, and receive the data from the source virtual machine via the selected data transport mode. The storage cluster may use the data to create the backup.

Abstract: The present invention relates to the field of biomedicine, and in particular to an engineered migrasome, a method for preparing the engineered migrasome, a delivery system comprising the engineered migrasome, and a method for preparing the delivery system.

Abstract: Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

Abstract: An inspection system and method, the inspection system includes: a carrying device, at least one ray source and a detector assembly. The ray source and the detector assembly are lifted or lowered along a central axis of the carrying device relative to the carrying device. When viewed along the central axis, the ray source is translatable between scanning positions relative to the carrying device. When the ray source is at one of the scanning positions the ray source and the detector assembly are lifted or lowered relative to the carrying device along the central axis, and the ray source emits X-rays; and when the ray source and the detector assembly are lifted or lowered a predetermined distance the ray source translates to another scanning position. The inspection system further reconstructs a three-dimensional scanning image of the object to be inspected based on detection data of the detector assembly.

Abstract: This disclosure provides a query task execution method, apparatus, computer device, storage medium. The method includes: receiving a query task for a target data table; determining at least one candidate degree of parallelism for executing the query task based on a first number of child tables obtained by pre-partitioning the target data table; selecting a target degree of parallelism within a preset range of degrees of parallelism from the at least one candidate degree of parallelism; and determining required computing units according to the target degree of parallelism, and evenly allocating the child tables to the computing units which concurrently execute the query task based on the allocated child tables.

Abstract: A data backup and recovery method and system using allocated data blocks include identifying a first snapshot associated with a virtual machine; accessing changed block tracking data associated with data changes occurred in the virtual machine, the data changes corresponding to a set of changed data blocks; accessing block allocation status data associated with the set of changed data blocks; identifying one or more allocated data blocks from the set of changed data blocks that are associated with allocated status based on the block allocation status data; and storing the one or more allocated data blocks to a storage device.

Abstract: A first communication apparatus obtains a first ciphertext data stream, and sends the first ciphertext data stream. The first ciphertext data stream includes a first alignment marker (AM) and an encrypted first data segment. At least one of some bits in a first AM lock information field in the first AM, some bits in a first lane identification information field in the first AM, or some or all bits in a first check information field in the first AM carry encryption parameter information of the first data segment.

Abstract: Example embodiments relate generally to data resynchronization methods and systems in continuous data protection (CDP) and more specifically to an input and output (I/O) filtering framework and log management system to seek a near-zero recovery point objective (RPO).

Abstract: A storage cluster may dynamically select a data transport mode for supporting a backup or export job. The storage cluster may receive a trigger indication to create, a backup of data of a source virtual machine. The storage cluster may select a data transport mode to use for reading the data from the source virtual machine to create the backup at the storage cluster. The selection may be from a set of data transport modes that includes a proxy virtual machine mode and a direct-to-host mode. The storage cluster may transmit, to a host for the source virtual machine, a request to activate the selected data transport mode, and receive the data from the source virtual machine via the selected data transport mode. The storage cluster may use the data to create the backup.

Abstract: A method of processing data determined from an image-charge/current signal representative of ions of a given charge state (Q) undergoing oscillatory motion of a respective oscillation frequency (f) within an ion analyser apparatus. A data set comprises a measured signal frequency (f0) common to a plurality of a measured image-charge/current signals and a plurality of estimated ion charge values corresponding to respective amplitudes of each one of the plurality of measured image-charge/current signals. An integer charge value ([Q]) is generated corresponding to a said estimated ion charge value rounded to the nearest integer value. Using the integer charge value ([Qi]) a plurality of different candidate image-charge/current signal frequency values (fCandi) are calculating according to said selected measured signal frequency (f0) and according to a corresponding one of one or more different candidate charge states of ion (e.g., protonation) and/or of ion isotope or isotopologue.

Abstract: The present disclosure provides a direct current (DC) transformer error detection apparatus for a pulsating harmonic signal, including a DC and pulsating harmonic current output module and an external detected input module, where the DC and pulsating harmonic current output module outputs a DC and a DC superimposed pulsating harmonic current to an internal sampling circuit and a self-calibrated standard resistor array; and the internal sampling circuit converts the input DC and the input DC superimposed pulsating harmonic current into a voltage signal, and sends the voltage signal to an analog-to-digital (AD) sampling and measurement component through a front-end conditioning circuit and a detected input channel. The DC transformer error detection apparatus can complete self-calibration for measurement of the DC and the pulsating harmonic signal on a test site.