Abstract: A method for preparing a migrasome by suppressing the cell volume-regulatory function and then produce a migrasome derived from the cell and a method for preparing a delivery system including a migrasome.

Abstract: The present disclosure provides a query method for a data table in a database, an apparatus, a computer device and a storage medium. The method includes: acquiring a data table query instruction, the data table query instruction is used to perform a Hash Join query operation on target join columns of a plurality of data tables in the database; constructing, in a build phase of the Hash Join, a hash data table according to tabular data corresponding to a target join column of a first data table among the plurality of data tables; determining, based on table statistical information of the hash data table, whether to construct a runtime filter for filtering a second data table in a probe phase of the Hash Join; and if so, determining a data query result with the constructed runtime filter based on the hash data table and the second data table.

Abstract: The present invention provides a negative reactance synthesizer comprising: a DC power source; a first converter configured for shaping an input current under an AC input voltage that has a given peak value and converting a variable DC voltage to a fixed DC voltage; a second converter configured for converting the fixed DC voltage to a stack-up DC voltage being greater than the peak value of the AC input voltage and stacked on the AC input voltage to form the variable DC voltage; a first control circuitry configured to generate a first gate driver signal and a first complementary gate drive signal for controlling the first converter; and a second control circuitry configured to generate a second gate driver signal and a second complementary gate drive signal for controlling the second converter. The present invention provides a simple and low-cost solution to emulate a standalone negative reactance.

Abstract: A plurality of different images of a same region of interest in an object are input into a set of neural networks, wherein each image of the region has been captured under a different value of a variable condition. A classification for each image is generated by the set of neural networks, wherein each classification includes a confidence score in a prediction of whether a feature is present in the region. The image classifications are ensembled to generate a final classification for the region. By applying a loss function, a loss is computed based on comparing the final classification to a ground truth of whether the feature is present in the region. The parameters of the set of neural networks are adjusted based on the computed loss.

Abstract: Example embodiments relate generally to data resynchronization methods and systems in continuous data protection (CDP) and more specifically to an input and output (I/O) filtering framework and log management system to seek a near-zero recovery point objective (RPO).

Abstract: A substrate includes a first base, a first trace, a first organic layer, a first inorganic layer, and a second trace. The first organic layer includes at least one first via hole, and a first via hole exposes a portion of the first trace. The first inorganic layer includes at least one second via hole. On the first base, an orthographic projection of an edge of an opening of a second via hole proximate to the first via hole is substantially coincident with an orthographic projection of an edge of an opening of the first via hole proximate to the second via hole. The first and second via holes are communicated to form a connecting hole to connect the first and second traces. A ratio of a depth of the connecting hole to a maximum radial dimension of the connecting hole ranges from 1:1 to 1:2, inclusive.

Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents such as siRNAs, able to Inhibin Subunit Beta E (INHBE) gene expression. Also disclosed are pharmaceutical compositions that include INHBE RNAi agents and methods of use thereof. The INHBE RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the INHBE RNAi agents in vivo provides for inhibition of INHBE gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by INHBE gene expression, such as obesity, diabetes, liver inflammation, dyslipidemia, or metabolic disease.

Abstract: Provided is a catenated VAR2CSA recombinant protein, a preparation therefor and a use thereof. The catenated VAR2CSA recombinant protein comprises a binding domain, SpyTag, a p53dim structural domain, and SpyCatcher, which are randomly arranged. The binding domain comprises a structural domain, in the VAR2CSA protein, binding to placenta-like chondroitin sulfate A. The catenated VAR2CSA recombinant protein has high stability and affinity to the tumor-specific antigen placenta-like chondroitin sulfate A, and can be effectively used in the field of tumor immunotherapy, such as immune cell therapy.

Abstract: Various embodiments of a method and apparatus for determining parametric timing yield and bottlenecks are disclosed which take into account correlation between electrical circuit paths through common timing arcs of an integrated circuit chip under design. Monte Carlo samples of timing arc delays are generated and used in computing timing yield and identify yield bottlenecks.

Abstract: An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.

Abstract: A rail train is provided in the embodiment of the present disclosure, comprising: a semi-enclosed air duct, the semi-enclosed air duct comprises an air duct top and an air duct side; the air duct top is fixed with an inner top of a rail train body, the air duct side is connected on both sides of the air duct top and extends downward; a large side top, and the the large side top is fixed to the rail train body as a part of a rail train roof, and the large side top is top-sealed at a bottom of the air duct side to form an air passage with the air duct. The rail train solves the technical problem that the roof and the air duct of the rail train are not conducive to overall weight reduction of the rail train.

Abstract: Provided is a hypochlorous acid disinfection water machine. The hypochlorous acid disinfection water machine includes a water inlet pipeline; a primary electrolyte cell, which is internally provided with a cation exchange membrane, and the outlet end of the water inlet pipeline communicates with the primary electrolyte cell; and a secondary electrolyte cell, which is a non-membrane electrolytic cell, a primary hypochlorous acid solution in an anode chamber of the primary electrolyte cell communicates with the secondary electrolyte cell, the primary hypochlorous acid solution in the anode chamber of the primary electrolyte cell is electrolyzed again in the secondary electrolyte cell to obtain a secondary hypochlorous acid solution. The hypochlorous acid disinfection water machine provided by the disclosure may solve the problem of poor concentration stability of a hypochlorous acid disinfection water machine in the relevant art.

Abstract: A storage cluster may dynamically select a data transport mode for supporting a backup or export job. The storage cluster may receive a trigger indication to create, a backup of data of a source virtual machine. The storage cluster may select a data transport mode to use for reading the data from the source virtual machine to create the backup at the storage cluster. The selection may be from a set of data transport modes that includes a proxy virtual machine mode and a direct-to-host mode. The storage cluster may transmit, to a host for the source virtual machine, a request to activate the selected data transport mode, and receive the data from the source virtual machine via the selected data transport mode. The storage cluster may use the data to create the backup.

Abstract: Provided is an indole compound. In particular, disclosed are a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof and a use of the same as an estrogen receptor antagonist in preparing a drug for treating estrogen receptor-positive breast cancer.

Abstract: The present invention relates to the field of biomedicine, and in particular to an engineered migrasome, a method for preparing the engineered migrasome, a delivery system comprising the engineered migrasome, and a method for preparing the delivery system.

Abstract: An inspection system and method, the inspection system includes: a carrying device, at least one ray source and a detector assembly. The ray source and the detector assembly are lifted or lowered along a central axis of the carrying device relative to the carrying device. When viewed along the central axis, the ray source is translatable between scanning positions relative to the carrying device. When the ray source is at one of the scanning positions the ray source and the detector assembly are lifted or lowered relative to the carrying device along the central axis, and the ray source emits X-rays; and when the ray source and the detector assembly are lifted or lowered a predetermined distance the ray source translates to another scanning position. The inspection system further reconstructs a three-dimensional scanning image of the object to be inspected based on detection data of the detector assembly.

Abstract: This disclosure provides a query task execution method, apparatus, computer device, storage medium. The method includes: receiving a query task for a target data table; determining at least one candidate degree of parallelism for executing the query task based on a first number of child tables obtained by pre-partitioning the target data table; selecting a target degree of parallelism within a preset range of degrees of parallelism from the at least one candidate degree of parallelism; and determining required computing units according to the target degree of parallelism, and evenly allocating the child tables to the computing units which concurrently execute the query task based on the allocated child tables.

Abstract: A data backup and recovery method and system using allocated data blocks include identifying a first snapshot associated with a virtual machine; accessing changed block tracking data associated with data changes occurred in the virtual machine, the data changes corresponding to a set of changed data blocks; accessing block allocation status data associated with the set of changed data blocks; identifying one or more allocated data blocks from the set of changed data blocks that are associated with allocated status based on the block allocation status data; and storing the one or more allocated data blocks to a storage device.

Abstract: A first communication apparatus obtains a first ciphertext data stream, and sends the first ciphertext data stream. The first ciphertext data stream includes a first alignment marker (AM) and an encrypted first data segment. At least one of some bits in a first AM lock information field in the first AM, some bits in a first lane identification information field in the first AM, or some or all bits in a first check information field in the first AM carry encryption parameter information of the first data segment.