Patents by Inventor Li Niu

Li Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8748407
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: June 10, 2014
    Assignee: The Research Foundation for the State University of New York
    Inventors: Li Niu, Zhen Huang
  • Publication number: 20130289100
    Abstract: Inhibitors of AMPA-type glutamate ion channels are useful as biochemical probes for structure-function studies and as drug candidates for a number of neurological disorders and diseases. Disclosed herein is the identification of an RNA inhibitor or aptamer by an in vitro evolution approach and characterization of its mechanism of inhibition on the sites of interaction by equilibrium binding and on the receptor channel-opening rate by a laser-pulse photolysis technique. The aptamer of the invention is a noncompetitive inhibitor of AMPA-type glutamate ion channels, one that selectively inhibits the GluA2Qflip AMPA receptor subunit without any effect on other AMPA receptor subunits or on kainate or NMDA receptors. Furthermore, the aptamer preferentially inhibits the closed-channel state of GluA2Qflip with a KI=1.5 ?M or by ˜15-fold over the open-channel state. The potency and selectivity of this aptamer rival those of small molecule inhibitors.
    Type: Application
    Filed: July 15, 2011
    Publication date: October 31, 2013
    Applicant: The Research Foundation for the State University of New York
    Inventors: Li Niu, Zhen Huang, Jae Seon Park
  • Patent number: 8450468
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: May 28, 2013
    Assignees: The Research Foundation for the State University of New York, Cornell University
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Patent number: 8383794
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: February 26, 2013
    Inventors: Li Niu, Zhen Huang
  • Publication number: 20120225929
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: December 12, 2011
    Publication date: September 6, 2012
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG, Hua SHI, John T. LIS
  • Publication number: 20120088818
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG
  • Patent number: 8076467
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: December 13, 2011
    Assignees: The Research Foundation of State University of New York, Cornell University
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Publication number: 20100099749
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: October 13, 2009
    Publication date: April 22, 2010
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG, Hua SHI, John T. LIS
  • Patent number: 7601823
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: October 13, 2009
    Assignees: Cornell University, The Research Foundation of State University of New York
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Publication number: 20060148746
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: October 24, 2005
    Publication date: July 6, 2006
    Inventors: Li Niu, Zhen Huang, Hua Shi, John Lis