Patents by Inventor Li Niu

Li Niu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid inhibitors of glutamate receptors
    Patent number: 8450468
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: May 28, 2013
    Assignees: The Research Foundation for the State University of New York, Cornell University
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Conformation-selective nucleic acid inhibitors of AMPA glutamate receptors
    Patent number: 8383794
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: February 26, 2013
    Inventors: Li Niu, Zhen Huang
  • Nucleic Acid Inhibitors Of Glutamate Receptors
    Publication number: 20120225929
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: December 12, 2011
    Publication date: September 6, 2012
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG, Hua SHI, John T. LIS
  • CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS
    Publication number: 20120088818
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG
  • Nucleic acid inhibitors of glutamate receptors
    Patent number: 8076467
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: December 13, 2011
    Assignees: The Research Foundation of State University of New York, Cornell University
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Nucleic Acid Inhibitors Of Glutamate Receptors
    Publication number: 20100099749
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: October 13, 2009
    Publication date: April 22, 2010
    Applicant: The Research Foundation of State University of New York
    Inventors: Li NIU, Zhen HUANG, Hua SHI, John T. LIS
  • Nucleic acid inhibitors of glutamate receptors
    Patent number: 7601823
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: October 13, 2009
    Assignees: Cornell University, The Research Foundation of State University of New York
    Inventors: Li Niu, Zhen Huang, Hua Shi, John T. Lis
  • Nucleic acid inhibitors of glutamate receptors
    Publication number: 20060148746
    Abstract: The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the ?-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors.
    Type: Application
    Filed: October 24, 2005
    Publication date: July 6, 2006
    Inventors: Li Niu, Zhen Huang, Hua Shi, John Lis