Abstract: Described herein are ralinepag prodrugs, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound, such as but not limited to pulmonary hypertension (PH) diseases.

Abstract: A photovoltaic module, including a plurality of solar cells each including a semiconductor substrate and a passivation layer, the semiconductor substrate is provided with an electrode including busbars, fingers, and electrode pads, each of the solar cells includes 9 to 20 busbars, each of the solar cells includes 40 to 100 fingers, and each of the busbars is connected to 3 to 10 electrode pads; a plurality of solder strips configured to connect the plurality of solar cells to each other, each of the solder strips fits the busbars and includes at least one boss portion soldered with the electrode pads, and a gradient of an outer surface of the boss portion along an extension direction of the solder strip ranges from 0° to 10°.

Abstract: The present application discloses a bionic induction type biological grouting device for uniformly reinforcing foundation soil, comprising an operation table, a rotating shaft and a rotating disc, at least two grouting pipes are arranged in a wall of a spiral guide pipe, a plurality of grout outlet holes are formed in an inner wall of the spiral guide pipe, a plurality of sets of grout spraying holes are formed in an outer wall of the spiral guide pipe in a rotation direction of the spiral guide pipe, and a plurality of adjusting components for controlling opening and closing of each set of grout spraying holes are arranged in the spiral guide pipe, and the plurality of adjusting components are linked through a flexible shaft.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: The present application discloses a bionic induction type biological grouting device for uniformly reinforcing foundation soil, comprising an operation table, a rotating shaft and a rotating disc, at least two grouting pipes are arranged in a wall of a spiral guide pipe, a plurality of grout outlet holes are formed in an inner wall of the spiral guide pipe, a plurality of sets of grout spraying holes are formed in an outer wall of the spiral guide pipe in a rotation direction of the spiral guide pipe, and a plurality of adjusting components for controlling opening and closing of each set of grout spraying holes are arranged in the spiral guide pipe, and the plurality of adjusting components are linked through a flexible shaft.

Abstract: Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Abstract: The present invention relates to a recombinant strain for producing shikimic acid, in which a target gene that regulates the asymmetric cell division and target genes that regulate the shikimic acid production are expressed The target gene that regulates the asymmetric cell division includes cytoskeletal protein PopZ coding gene popZ, and the target genes that regulate the shikimic acid production include DAHP synthase coding gene aroG, 3-dehydroquinate synthase coding gene aroB, and transketolase coding gene tktA. The recombinant strain of the present invention realizes the de novo synthesis of shikimic acid using glucose as a substrate, with a low cost. After fermentation with the strain in a 7.5 L fermentor, the highest production of shikimic acid is 88.1 g/L, the yield is 0.33 g/g, and the production intensity of shikimic acid is 1.1 g/L/h.

Abstract: The disclosure relates to a light train control system applied to oversea freight railways. The system integrates automatic block, station turnout control and train operation overspeed protection control and comprises an on-board subsystem, an RBC subsystem and a satellite positioning differential base station management subsystem, wherein the on-board subsystem is respectively connected to the RBC subsystem and the satellite positioning differential base station management subsystem.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: The application discloses a reversible plugging-type device for preventing seepage from a side wall of an irregular sample (14), comprising a sleeve (15) with both ends open, a primary lantern ring (4), a secondary lantern ring (5), a tertiary lantern ring (26) and a rotation shaft (1) arranged in a barrel (2), a lower end surface of the barrel (2) is provided with an annular floating plate (17), the primary lantern ring (4), the secondary lantern ring (5), and the tertiary lantern ring (26) are hollow, first phase liquid pipe (7) is arranged on a lower end surface of the primary lantern ring (4), second phase liquid pipe (8) is arranged on a lower end surface of the secondary lantern ring (5), the first phase liquid pipe (7) and the second phase liquid pipe (8) extend downward toward a mixing pipe (10). The floating plate (17) has the mixing pipe (10), which runs through the floating plate (17) and has a discharging pipe (22) provided with a discharge port (23).

Abstract: A fan device includes a hub and a plurality of fan blades. Each of the fan blades includes a driving surface, and the driving surface includes a first tooth column and a second tooth column. The first tooth column includes a plurality of first skin-tooth units. Each of the first skin-tooth units includes a first body. A first middle ridge and two first side ridges protrude from a surface of the first body, and a groove is formed between two adjacent first skin-tooth units. The second tooth column includes a plurality of second skin-tooth units. Each of the second skin-tooth units includes a second body and an extension element. A second middle ridge and two second side ridges protrude from a surface of the second body, and the extension element is located in the groove and includes an extension rib.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.

Abstract: An herbal distillation device includes a herb chamber with perforated holes for holding herbs and a closed heated boiling chamber with openings at the side for a steam outlet. The herbal distillation device further includes an electric air-cooled condensation chamber which connects to the boiling chamber.

Abstract: A client device configured to store data in a database of a data storage server is provided. The data storage server stores security sensitive data in one or more encrypted data structures of the database. The client device is configured to determine whether data to be stored in the database comprises security sensitive data to be stored in an encrypted data structure of the database and to encrypt this security sensitive data with an encryption key. Furthermore, the client device is configured to provide the data, including the encrypted security sensitive data, and an identifier of the encryption key to the server for storing, based on the identifier of the encryption key, the security sensitive data in the encrypted data structure of the database. According to the present disclosure, the security sensitive data which is already encrypted at the client device improves a secure protection of the data.

Abstract: Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.

Abstract: A method for activating a cell-signaling pathway of interest in a cell, including applying a time-modulated localized alternating current electrical field to the cell, wherein the amplitude and frequency of the localized alternating current electrical field is selected to activate the cell signaling pathway of interest, thereby activating the cell signaling pathway.