Patents by Inventor Liang Zhu

Liang Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted quinazolines for inhibiting kinase activity
    Patent number: 10653701
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: May 19, 2020
    Assignee: NEUPHARMA, INC.
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • Certain chemical entities, compositions, and methods
    Patent number: 10590106
    Abstract: Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: March 17, 2020
    Assignee: NeuPharma, Inc.
    Inventors: Yong-Liang Zhu, Xiangping Qian
  • Adsorption Mechanism, Cleaning Device, Chemiluminescence Detector and Cleaning Method
    Publication number: 20200080998
    Abstract: The present disclosure relates to a magnetic microbeads adsorption mechanism, which is configured to adsorb a magnetic microbeads in a reaction cup and is provided with a cup inlet station and a cup outlet station; the magnetic microbeads adsorption mechanism includes a pedestal, a turntable and multiple magnetic adsorption components; the turntable is rotatably mounted on the pedestal; the turntable can drive the reaction cup to rotate around a central axis of the turntable; the multiple magnetic adsorption components are arranged on a mounting circumference of the pedestal at intervals; the mounting circumference and rotation track of the reaction cup are concentrically arranged; and during a process when the reaction cup rotates from the cup inlet station to the cup outlet station, the adsorption height of the magnetic microbeads relative to cup bottom of the reaction cup can be changed.
    Type: Application
    Filed: January 21, 2019
    Publication date: March 12, 2020
    Inventors: Liang ZHU, Li YIN, Yi HU, Dingping BAN, Wanguan YI, Shuai TONG
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
    Publication number: 20200055828
    Abstract: Chemical entities based on quinoxaline that are kinase inhibitors are described. Specifically, quinoxaline derivatives of Formula I, containing a diarylamide or diarylurea substructure that inhibit Braf mutant kinase activity, pharmaceutical compositions containing the inhibitor compounds and methods of treatment of cancer comprising administering an effective amount of the Braf inhibitor compound are described.
    Type: Application
    Filed: March 20, 2019
    Publication date: February 20, 2020
    Inventors: Xiangping QIAN, Yong-Liang ZHU
  • Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
    Patent number: 10561652
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: February 18, 2020
    Assignee: NEUPHARMA, INC.
    Inventors: Yong-Liang Zhu, Xiangping Qian
  • Precursors for lithium transition metal oxide cathode materials for rechargeable batteries
    Patent number: 10547056
    Abstract: A particulate precursor compound for manufacturing a lithium transition metal (M)-oxide powder for use as an active positive electrode material in lithium-ion batteries, wherein (M) is NixMnyCozAv, A being a dopant, wherein 0.33?x?0.60, 0.20?y?0.33, and 0.20?z?0.33, v?0.05, and x+y+z+v=1, the precursor comprising Ni, Mn and Co in a molar ratio x:y:z and having a specific surface area BET in m2/g and a sulfur content S expressed in wt %, wherein formula (I).
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: January 28, 2020
    Assignees: UMICORE, UMICORE KOREA, LTD.
    Inventors: Liang Zhu, Randy De Palma, Hyo Sun Ahn, Sung Jun Cho, Daniël Nelis, Kris Driesen
  • Certain chemical entities, compositions, and methods
    Patent number: 10544106
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: January 28, 2020
    Assignee: NEUPHARMA, INC.
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • PRECURSORS FOR CATHODE MATERIAL WITH IMPROVED SECONDARY BATTERY PERFORMANCE AND METHOD TO PREPARE THE PRECURSORS
    Publication number: 20200006769
    Abstract: A crystalline precursor compound for manufacturing a lithium transition metal based oxide powder usable as an active positive electrode material in lithium-ion batteries, the precursor having a general formula M(O)x(OH)2-x-y(CO3)y, with 0<x?1, 0<y<0.03 and M=NiaMnbCocAd. A being a dopant, with 0.30?a<0.90, 0.10?b<0.40, 0.10?c<0.40, d<0.05 and a+b+c+d=1, the precursor having a Na content less than 200 ppm, a S content less than 250 ppm, the precursor having a specific surface area with a BET value expressed in m2/g and a tap density TD expressed in g/cm3, with a ratio BET/TD>30.104 cm5/g2.
    Type: Application
    Filed: March 14, 2017
    Publication date: January 2, 2020
    Inventors: Jens PAULSEN, Daniël NELIS, Jin HU, Liang ZHU, Eric ROBERT
  • BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER
    Publication number: 20190365747
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
    Type: Application
    Filed: April 4, 2019
    Publication date: December 5, 2019
    Inventors: Yong-Liang Zhu, Xiangping Qian
  • Doped and coated lithium transition metal oxide cathode materials for batteries in automotive applications
    Patent number: 10490807
    Abstract: A lithium metal oxide powder for use as a cathode material in a rechargeable battery, consisting of Li metal oxide core particles having a general formula Li1+d(NixMnyCozZrkM?m)i?dO2±eAr; wherein Al2O3 is attached to the surface of the core particles; wherein 0?d?0.08, 0.2?x?0.9, 0<y?0.7, 0<z?0.4, 0?m?0.02, 0<k?0.05, e<0.02, 0?f?0.02 and x+y+z+k+m=1; M? consisting of either one or more elements from the group Al, Mg, Ti, Cr, V, Fe and Ga; A consisting of either one or more elements from the group F, P, C, CI, S, Si, Ba, Y, Ca, B, Sn, Sb, Na and Zn; and wherein the Al2O3 content in the powder is between 0.05 and 1 wt %.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 26, 2019
    Assignees: Umicore, Umicore Korea Ltd.
    Inventors: Liang Zhu, Jens Paulsen, Hyo Sun Ahn, HeonPyo Hong
  • CONTROL DEVICE FOR A GIMBAL AND METHOD OF CONTROLLING THE SAME
    Publication number: 20190331289
    Abstract: A gimbal for controlling an optical device includes a rocker and a controlling assembly. The rocker is configured to receive an action instruction and generate a control instruction based on the action instruction. The action instruction includes a long press when a rocker handle of the rocker is deviated from a middle position, and the control instruction includes a back-to-middle control instruction instructing the rocker handle to return to the middle position. The controlling assembly is configured to receive the control instruction from the rocker, and generate a performing instruction based on the control instruction for controlling the optical device.
    Type: Application
    Filed: July 11, 2019
    Publication date: October 31, 2019
    Inventors: Paul PAN, Ming Liang ZHU, Xi Feng ZHAO
  • Certain chemical entities, compositions, and methods
    Patent number: 10457641
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: October 29, 2019
    Assignee: NEUPHARMA, INC.
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • Motion sensor for occupancy detection and intrusion detection
    Patent number: 10445998
    Abstract: A motion sensor has an infrared detector with a first set of detector elements coupled to a first channel and a second set of detector elements coupled to a second channel. A first optical subsystem directs infrared radiation from a first number of monitored volumes to the infrared detector and a second optical subsystem directs infrared radiation from a second number of monitored volumes to the infrared detector. Intrusion detection circuitry is coupled to both channels of the infrared detector and selects a set of peaks in the first channel and the second channel. It then calculates an alternation score based on a number of alternating peaks in the set of peaks, and indicates an intrusion detection based, at least in part, on the alternation score. The circuitry also determines a peak-to-peak period for the first channel and calculates a slope-synchrony measurement to modify the alternation score.
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: October 15, 2019
    Inventors: Eric Scott Micko, Guang Liang Zhu
  • SUBSTITUTED QUINAZOLINES FOR INHIBITING KINASE ACTIVITY
    Publication number: 20190307767
    Abstract: Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Application
    Filed: November 13, 2018
    Publication date: October 10, 2019
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • ACRIDINE LABELLED CONJUGATES AND PREPARATION METHODS THEREFOR AND CHEMILUMINESCENT KITS
    Publication number: 20190309030
    Abstract: Disclosed are an acridine marker conjugate and a preparation method therefor and a chemiluminescent kit. The acridine marker conjugate comprises an acridine substitute, a carrier protein and a protein to be marked sequentially connected. The carrier protein is a protein containing carboxyl and amino, a modified protein, a polypeptide or a modified polypeptide; and the protein to be marked is a protein containing amino, a modified protein, a polypeptide or a modified polypeptide.
    Type: Application
    Filed: July 5, 2016
    Publication date: October 10, 2019
    Inventors: Fuzhen XIA, Taoxu LIU, Liang ZHU, Chengyong XIAO, Chungen QIAN
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 10426760
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Grant
    Filed: August 22, 2018
    Date of Patent: October 1, 2019
    Assignee: Plexxikon Inc.
    Inventors: Guoxian Wu, Jiazhong Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai
  • Rotary switch state detection device
    Patent number: 10401432
    Abstract: A rotary switch state detection device includes a magnetic field generating unit, a gravity sensing unit, a magnetic force sensing unit and a processing unit. The magnetic field generating unit generates a magnetic field. The magnetic force sensing unit and the gravity sensing unit are disposed at a rotary switch to detect a gravity value and a magnetic force value of the magnetic field and generate a gravity strength signal and magnetic field strength signal, respectively. The processing unit is connected to the gravity sensing unit and the magnetic force sensing unit to calculate a gravity value variation and a magnetic force value variation and thereby precisely locate a rotation head of the rotary switch upon completion of rotation thereof.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: September 3, 2019
    Assignee: NATIONAL CHUNG SHAN INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Yu-Shan Lin, Jun-Liang Zhu, Tung-Jung Hsu, Chao-Tse Hong
  • Flavonoid IL-17A inhibitors
    Patent number: 10385034
    Abstract: The present invention describes compounds according to formula I: and compounds according to formula II: and additional related flavonoid compounds, as well as the use of the compounds in methods for the prevention or treatment of IL-17A-mediated disease in a subject.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: August 20, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Xiaoxia Li, Caini Liu, Jun Qin, Liang Zhu, Koichi Fukuda
  • Control device for a gimbal and method of controlling the same
    Patent number: 10352495
    Abstract: A gimbal for controlling an optical device includes a rocker and a controlling assembly. The rocker is configured to receive an action instruction and generate a control instruction based at least in part on a duration of the action instruction. The controlling assembly is configured to (1) receive the control instruction from the rocker, and (2) generate, based on the control instruction, a performing instruction for controlling the optical device.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: July 16, 2019
    Assignee: SZ DJI OSMO TECHNOLOGY CO., LTD.
    Inventors: Paul Pan, Ming Liang Zhu, Xi Feng Zhao
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20190209536
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: August 8, 2018
    Publication date: July 11, 2019
    Inventors: Guoxian Wu, Jiazhon Zhang, Yong-Liang Zhu, Chao Zhang, Prabha N. Ibrahim, Songyuan Shi, Wayne Spevak, Dean R. Artis, James Tsai