Abstract: Disclosed are a crystal form of an estrogen receptor inhibitor and a preparation method therefor, in particular disclosed are a crystal form A of a compound of formula (I) and a preparation method therefor, and the use of the crystal form in the preparation of a drug for treating breast cancer.

Abstract: Disclosed is a class of new aryl-phosphorus-oxygen compounds as shown in formula (I) as EGFR kinase inhibitors, and pharmaceutically acceptable salts thereof.

Abstract: Disclosed is a novel quinazoline compound. Specifically, disclosed are a compound represented by the formula (I) and a pharmacologically acceptable salt.

Abstract: Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.

Abstract: A shower control system has a controller and a control panel. The control panel includes a knob. The top surface of the knob has an inner ring and an outer ring; the outer ring has outlet buttons corresponding to a first outlet and a second outlet; when the outlet button is touched, the circuit of the controller sends a signal to the electromagnetic valve to open the first outlet or the second outlet; the inner ring is disposed with a display screen with a temperature displaying area, a volume displaying area, a temperature adjusting mode icon, a volume adjusting mode icon and a lock mode icon; when the knob is long pressed, the control panel is open, the inner ring lights up; the temperature displaying area, the volume displaying area of the displayer screen respectively displays the temperature and volume last used, and the lock mode icon is selected.

Abstract: Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.

Abstract: The invention provides a waterway switch switching valve, which comprises: valve body, main control valve core and waterway control valve core; the valve body comprises a water inlet channel, a first water outlet and a second water outlet, the number of waterway control valve core corresponds to the number of water outlets one by one, and is divided into the first and second waterway control valve core; the first waterway control valve core and the second waterway control valve core are respectively installed in the valve body; The valve body also comprises a first waterway arranged between the water inlet channel and the first waterway control valve core; and a second waterway between the first waterway control valve core and the second waterway control valve core; when the first waterway control valve core is opened, the first waterway control valve core connects the first waterway with the first water outlet; when the first waterway control valve core is closed, the first waterway control valve core connec

Abstract: Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.

Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed in the present invention is a type of indole substituted piperidine compounds as an estrogen receptor degrading agent. Specifically disclosed are a compound as shown in formula (I), a pharmaceutically acceptable salt, hydrate or prodrug thereof, a preparation method therefor, a pharmaceutical composition thereof, and a use thereof as an estrogen receptor degrading agent in the treatment of estrogen receptor positive breast cancers.

Abstract: Disclosed is a series of compounds acting as CDK4/6 inhibitors. Specifically disclosed are compounds as represented by formula (I), pharmaceutically acceptable salts or isomers thereof, pharmaceutical compositions containing same, and the use thereof in the preparation of drugs for treating cancers.

Abstract: Disclosed in the present invention is a type of pyridone compounds as c-met inhibitors, and specifically disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: An automatically resettable press-type switching valve includes a valve housing, an operating portion, a driven rod, a water blocking member, and a resetting member. The valve housing is formed therein with an inlet and outlet passages. A water blocking seat is provided between the inlet and outlet passages. The operating portion drives the driven rod to move axially so as to form a forward pressure difference or reverse pressure difference between two opposing sides of the water blocking member, by which the water blocking member is pushed to move axially with the driven rod. The resetting member is drivingly connected with the water blocking member, when there is no water pressure at a side of the inlet passage, the resetting member drives the water blocking member to separate from the water blocking seat, and the inlet passage is communicated with the outlet passage.

Abstract: Provided is a dihydropyrazole azepine compound serving as an Akt inhibitor; specifically disclosed is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A crystal form and a salt type of a substituted 2-hydro-pyrazole derivative, preparation method therefor, and use of the crystal form and the salt type in preparation of a medicament for treating cancers such as breast cancer, lung cancer and the like.

Abstract: Disclosed is a new indole compound, in particular, the compound as shown in formula (I), and a preparation method, pharmaceutical composition and use thereof as an estrogen receptor down-regulator in preparing drugs for treating estrogen receptor-positive breast cancer.

Abstract: The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, m, R1, R2, R3, R3, R3, R4, R5 and R9 are as defined herein. The present invention also relates to compositions comprising at least one Fused Tricyclic Heterocycle Derivative, and methods of using the Fused Tricyclic Heterocycle Derivatives for treating or preventing HIV infection in a subject.

Abstract: The present invention relates to Spirocyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, X, Y, R1, R2 and R4 are as defined herein. The present invention also relates to compositions comprising at least one Spirocyclic Heterocycle Compound, and methods of using the Spirocyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Abstract: A rationed water outlet device with a variable water flow volume includes a process control module including an outlet valve, a flow meter, a control chip, and an encoder that includes an unlimited outlet gear and a plurality of rationed outlet gears which are switchably connected to the outlet valve to provide respectively, when engaged, an unlimited water flow volume or a selected rationed water flow volume from among a plurality of rationed water flow volumes, and that is electrically connected to the control chip to provide gear selection information; a volume option switch that is rotatably linked to the encoder for engaging the unlimited outlet gear or one rationed outlet gear; and an outlet control switch that is independent of the volume option switch and that is engaged after the volume option switch is engaged.