Abstract: The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.

Abstract: An electronic intelligent touch control water faucet and an intelligent water supply central processor which includes a main body, an upper cover, an electromagnetic valve group, a temperature control and flow control member, a PCB control panel and an operation panel. The main body includes receiving troughs, two water inlet tubes and a water outlet tube communicated through pipes. The temperature control member includes a temperature control valve, a synchronous motor, and a temperature sensor. The temperature control valve communicates with the water inlet tubes and is driven and adjusted by the synchronous motor. PCB control panel controls the synchronous motor. The temperature sensor communicates the outlet water temperature to the PCB control panel. The flow control member includes a flow valve and a motor. The PCB control panel controls the motor driving the flow valve. The flow valve water outlet is connected to the water outlet tube.

Abstract: The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.

Abstract: The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.