Abstract: This disclosure relates to hyaluronic acid nanoparticles containing an anticancer agent such as a NADPH oxidase (NOX) inhibitor for targeted delivery to cancerous cells or tumors. In certain embodiments, the nanoparticles are made up of hyaluronic acid conjugated to hydrophobic moieties. In certain embodiments, the hydrophobic moieties are steroid based compounds, such as 5beta-cholanic acid.

Abstract: An apparatus and system to mitigate non-genuine handovers are described. The handovers include handovers based on fake measurements and handovers to malicious cells. To mitigate these, a mitigation procedure is initiated when excessive handovers are detected. Location information obtained from the UE, estimation of PHY layer properties by the serving and/or target cell, or AI modeling of the best serving cell at the UE location is used to determine whether the handover is valid. If not, the handover is canceled and the UE is stopped from initiating new handovers for a specified time, the UE may be instructed to perform re-authentication with the network, and/or the serving cell recommends to the network authentication entity to revoke the UE authentication. To ensure that the target cell is legitimate, an AI model is used to classify the target cell as known/unknown and the result sent to the network in NAS signaling.

Abstract: A computing node includes network interface circuitry and processing circuitry. The processing circuitry assigns available computing resources to a plurality of slice contexts. Each slice context of the plurality includes resource allocations of the available computing resources associated with multiple communication networks. A first portion of the resource allocations is designated as dedicated resources and a second, remaining portion is designated as shared resources. A FAFO event associated with a workload is detected. The workload executes on a network slice instance (NSI) associated with a slice context of a subset of slice contexts. The configuration of the NSI is restored to a pre-FAFO event state based on reconfiguring one or both of the dedicated resources or the shared resources of the slice context based on the resource allocations of at least a second slice context in the subset of slice contexts.

Abstract: A computing node to implement a management entity in a CP-based network. The node including processing circuitry configured to encode an inquiry message requesting information on CPS capabilities. Response messages are received from a set of sensing nodes of a plurality of sensing nodes in response to the inquiry message. The response messages include the information on the CPS capabilities of the set of sensing nodes. A notification message indicating selecting of a sensing node as a sensing coordinator is encoded for transmission. Sensed data received in a broadcast message from the sensing coordinator is decoded. The sensed data including data associated with one or more non-V2X capable sensing nodes.

Abstract: Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.

Abstract: A computing node includes interface circuitry and processing circuitry. To implement a spectrum harvesting entity in a wireless network configured for crowdsource-based unlicensed spectrum harvesting, the processing circuitry is configured to select a set of crowdsourcing nodes from a plurality of crowdsourcing nodes available in the wireless network. A plurality of spectrum occupancy reports (SORs) is received from the set of crowdsourcing. Each of the plurality of SORs indicates a channel occupancy status of a communication channel in the unlicensed spectrum sensed by a corresponding crowdsourcing node of the set and geolocation associated with the corresponding crowdsourcing node. A spectrum occupancy map of the unlicensed spectrum is generated based on the channel occupancy status and the geolocation provided in the plurality of SORs by each crowdsourcing node of the set of crowdsourcing nodes.

Abstract: An optimal pulse power measurement method for multinuclear simultaneous integrated magnetic resonance imaging includes the following steps: successively or simultaneously exciting multiple nuclides within a slice in a same repetition time (TR) of magnetic resonance imaging (MRI); applying, in a slice encoding gradient channel, a frequency encoding gradient in a direction opposite to a slice selection gradient, and acquiring free induction decay (FID) signals of all the nuclides; simultaneously changing shaped radiofrequency (RF) pulse power values of all the nuclides for multiple times, and acquiring multiple corresponding FID signals for each nuclide; and performing Fourier transform on the FID signals of each nuclide, selecting a spectral peak in an absolute spectrum, integrating the spectral peak for comparison, and taking a shaped RF pulse power value corresponding to a maximum signal intensity of each nuclide as an optimal shaped RF pulse power corresponding to a current TR.

Abstract: A phantom for multinuclear simultaneous integrated magnetic resonance imaging includes a plurality of sealed containers, where a partition I and a partition II are provided in the sealed container and intersect with each other; the partition I and the partition II divide the sealed container into a plurality of subspaces that are interconnected; a thickness of the partition I is equal to a resolution of a nuclide 1H, and a thickness of the partition II is ?H/?X times of the resolution of the nuclide 1H, where ?H is a gyromagnetic ratio of the nuclide 1H, and ?X is a gyromagnetic ratio of a pre-imaging nuclide X; the sealed container is filled with a mixture; and the mixture includes all pre-imaging nuclides. In the phantom, the partition I and the partition II are designed according to a ratio of gyromagnetic ratios of nuclides, and are combined with a mixture including all pre-imaging nuclides.

Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

Abstract: This disclosure relates to palladium hyaluronic acid particles such as dibenzylideneacetone palladium hyaluronic acid particles. In certain embodiments, this disclosure relates to methods of managing cancer or angiogenic conditions using particles disclosed herein and pharmaceutical compositions comprising the same. In certain embodiments, an objective of this disclosure is hyaluronic acid targeting of CD44, a tumor stem cell marker. In certain embodiments, this disclosure relates to treatment with hyaluronic acid palladium particles disclosed herein for depleting CD44 cells.

Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

Abstract: Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.

Abstract: This disclosure relates to peptides and nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.

Abstract: The invention relates to a method for forming flip chip bumps using electroplating. The method allows the formation of flip chip bumps in a way that is compatible with already-formed sensitive electronic components, such as Josephson junctions, which may be used in quantum processing units. The invention also relates to a product and a flip chip package in which flip chip bumps are formed with the disclosed method.

Abstract: A magnetic resonance imaging (MRI) system and method integrating multi-nuclide synchronous imaging and spectral imaging is provided. The MRI system includes a spectral imaging module, a multi-nuclide synchronous imaging module, and a spectral reconstruction and image fusion module, where the spectral imaging module is configured to acquire a spectrum of a nuclide Nuc; the multi-nuclide synchronous imaging module is configured to perform synchronous imaging of nuclides Nuc1 . . . Nucn, where when n=1, Nucl is 1H; and when n>1, Nucn is a non-1H nuclide; and the spectral reconstruction and image fusion module is configured to receive the spectrum of the nuclide Nuc and images of the nuclides Nuc1 . . . Nucn, and acquire spatial distribution information of compounds of the nuclide Nuc and spatial distribution information of the non-1H nuclide through fusion. The system and method can synchronously acquire MR signals of different nuclides, and reconstruct and fuse non-1H nuclide images.

Abstract: A system and method for authenticating users of a data processing platform stores a mapping of a unique user platform identifier to multiple user identity provider identifiers associated with multiple realms for a same user. In some examples, the method includes receiving a request from a client device to establish an access session to perform one or more actions on data of the data processing platform and receiving, from at least one of the first external identity provider of the first realm or the second external identity provider of the second realm, a user identity provider identifier associated with the request. In certain examples, the method includes granting permission to perform the one or more actions on the data of the data processing platform based at least in part on the received user identity provider identifier.

Abstract: This disclosure relates to peptides and nanoparticles comprising a surface molecule that binds or blocks PD-L1. In certain embodiments, the disclosure relates to methods of using peptides or nanoparticles disclosed herein for the treatment of cancer. In certain embodiments, the disclosure relates to methods of using nanoparticles disclosed herein for therapeutic and diagnostic applications.

Abstract: A magnetic resonance imaging (MRI) system and method integrating multi-nuclide synchronous imaging and spectral imaging is provided. The MRI system includes a spectral imaging module, a multi-nuclide synchronous imaging module, and a spectral reconstruction and image fusion module, where the spectral imaging module is configured to acquire a spectrum of a nuclide Nuc; the multi-nuclide synchronous imaging module is configured to perform synchronous imaging of nuclides Nuc1 . . . . Nucn, where when n=1, Nucl is 1H; and when n>1, Nucn is a non-1H nuclide; and the spectral reconstruction and image fusion module is configured to receive the spectrum of the nuclide Nuc and images of the nuclides Nuc1 . . . . Nucn, and acquire spatial distribution information of compounds of the nuclide Nuc and spatial distribution information of the non-1H nuclide through fusion. The system and method can synchronously acquire MR signals of different nuclides, and reconstruct and fuse non-1H nuclide images.

Abstract: The invention relates to the field of oilfield chemistry, and discloses a self-repairing plugging gel polymer for drilling fluid, a preparation method and application thereof, and the drilling fluid containing the gel polymer, wherein the polymer contains a structural unit A, a structural unit B, a structural unit C and a structural unit D, and the structural unit A is a structural unit with a structure shown in the formula (1); the structural unit B is a structural unit with a structure shown in the formula (2); the structural unit C is a structural unit with a structure shown in the formula (3); the structural unit D is a structural unit having a structure represented by the formula (4).

Abstract: A lifting device for building a steel structure hoistway and a method for building a steel structure hoistway. The lifting device includes a lifting mechanism and a crane mechanism. The lifting mechanism includes a bottom platform, a middle platform and a top platform. The crane mechanism is arranged on the top platform of the lifting mechanism, and includes a base and a crane on the base. The base is arranged on the top platform and is rotatable relative to the top platform along a vertical axis, and the hanger frame of the crane is movable between a vertical orientation and an inclined orientation. The lifting mechanism is configured to ascend and descend in the constructed steel structure hoistway, and the crane mechanism is configured to lift building materials, such as steel beams, steel columns, etc., for use in building the steel structure hoistway to their designed installation locations.