Patents by Inventor Lily Yang

Lily Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210385239
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for anomaly detection and recovery. An apparatus to isolate a first controller in an autonomous vehicle includes a first controller to control a reference signal of the autonomous vehicle via a communication bus, a second controller to control the reference signal of the autonomous vehicle when the first controller is compromised, and a message neutralizer to neutralize messages transmitted by the first controller when the first controller is compromised, the neutralized messages to cause the first controller to become isolated from the communication bus.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 9, 2021
    Inventors: Marcio Juliato, Liuyang Lily Yang, Manoj Sastry, Christopher Gutierrez, Shabbir Ahmed, Vuk Lesi
  • Patent number: 11192964
    Abstract: A preparation method of an ionic liquid shale inhibitor for drilling fluid comprises the following step: subjecting the imidazole-based ionic liquid to a polymerization reaction in water environment under an inert atmosphere, and the produced polymer is used as an ionic liquid shale inhibitor for drilling fluid. The ionic liquid shale inhibitor for drilling fluid has the advantages of desirable inhibition effect, good compatibility, strong high-temperature resistance, simple preparation method and low cost.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: December 7, 2021
    Assignee: CHINA UNIVERSITY OF PETROLEUM (BEIJING)
    Inventors: Lili Yang, Guancheng Jiang, Xiao Yang, Tengda Wang, Yawei Shi
  • Publication number: 20210348046
    Abstract: The invention relates to the field of drilling fluid, in particular to a saturated salt water drilling fluid of salt response type intelligent polymer and preparation method thereof. The drilling fluid contains two or more of the following components stored in admixture or separately: bentonite, NaOH, KCl, calcium carbonate, barite, NaCl, supramolecular fluid loss additive, supramolecular shear-enhancing agent, plugging agent, coating agent and water. The drilling fluid provided by the invention has the characteristics of salt response and self-assembly, can keep rheological properties such as rapid recovery of the sheared structure, low extreme high shear rate viscosity, good shear dilution property and the like in a high-salt environment, has good fluid loss reduction performance, reservoir protection performance and debris dispersion inhibition performance, and has good temperature resistance and pollution resistance performance.
    Type: Application
    Filed: May 11, 2021
    Publication date: November 11, 2021
    Applicant: China University of Petroleum (Beijing)
    Inventors: Guancheng JIANG, Yinbo HE, Lili YANG, Tengfei DONG, Xiaohu QUAN, Kai WANG, Chunyao PENG, Xuwu LUO, Bin TAN, Jun CAI, Xing LIANG, Zhiliang YOU, Yong WANG
  • Publication number: 20210324035
    Abstract: Tumor-specific T cell receptor (TCR) gene transfer enables specific and potent immune targeting of tumor antigens. The canonical cancer-testis antigen, NY-ESO-1, is not expressed in normal tissues but is aberrantly expressed across a broad array of cancer types. It has also been targeted with A2-restricted TCR gene therapy without adverse events or notable side effects. To enable the targeting of NY-ESO-1 in a broader array of HLA haplotypes, we isolated TCRs specific for NY-ESO-1 epitopes presented by four MHC molecules: HLA-A2, -B07, -B18, and -C03. Using these TCRs, we have developed an approach to extend TCR gene therapies targeting NY-ESO-1 to patient populations beyond those expressing HLA-A2.
    Type: Application
    Filed: September 4, 2019
    Publication date: October 21, 2021
    Applicants: The Regents of the University of California, California Institute of Technology, The Olivia Newton-John Cancer Research Institute
    Inventors: Owen N. Witte, Jami McLaughlin Witte, Antoni Ribas, Lili Yang, Michael T. Bethune, Jonathan Cebon, Katherine Woods, Ashley J. Knights, David Baltimore
  • Patent number: 11136488
    Abstract: The present invention relates to the technical field of oil and gas drilling, and discloses a biodiesel-based constant rheological property drilling fluid containing intelligent temperature responsive polymer, which contains two or more of the following components which are stored in admixture or separately: base oil biodiesel, aqueous phase, emulsifier, organic soil, constant rheological property flow pattern modifier, hydrolysis inhibitor, filtrate reducer and weighting material; the constant rheological property flow pattern modifier is an intelligent temperature responsive polymer, and the polymer contains structural units provided by bis-hydroxyethyl bis-hydroxypropyl stearyl ammonium chloride, ethylene bis-stearamide and dimerized fatty acid.
    Type: Grant
    Filed: April 12, 2021
    Date of Patent: October 5, 2021
    Assignee: CHINA UNIVERSITY OF GEOSCIENCES (BEIJING)
    Inventors: Guancheng Jiang, He Shi, Kaixiao Cui, Yinbo He, Lili Yang, Tengfei Dong, Chunyao Peng, Xuwu Luo, Bin Tan, Jun Cai, Xing Liang, Zhiliang You, Yong Wang
  • Patent number: 11123033
    Abstract: Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: September 21, 2021
    Assignee: Harbin Medical University
    Inventors: Xilin Sun, Zhen Quan, Ruifeng Wang, Kai Wang, Lili Yang, Zunyu Xiao, Yang Liu, Zhaoguo Han, Xiang Liu, Mingxing Ke
  • Patent number: 11038909
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for anomaly detection and recovery. An apparatus to isolate a first controller in an autonomous vehicle includes a first controller to control a reference signal of the autonomous vehicle via a communication bus, a second controller to control the reference signal of the autonomous vehicle when the first controller is compromised, and a message neutralizer to neutralize messages transmitted by the first controller when the first controller is compromised, the neutralized messages to cause the first controller to become isolated from the communication bus.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: June 15, 2021
    Assignee: Intel Corporation
    Inventors: Marcio Juliato, Liuyang Lily Yang, Manoj Sastry, Christopher Gutierrez, Shabbir Ahmed, Vuk Lesi
  • Patent number: 11034876
    Abstract: The invention discloses a calcium-resistant zwitterionic polymer, a preparation method and an application thereof, and a water-based drilling fluid containing the polymer as a dispersing agent, wherein the polymer contains a structural unit A, a structural unit B and a structural unit C, and the structural unit A is at least one selected from the group consisting of structural units with a structure shown in a formula (11), a structure shown in a formula (12) and a structure shown in a formula (13); the structural unit B is a structural unit with a structure shown in a formula (2); the structural unit C is at least one selected from the group consisting of structural units having a structure represented by formula (31) and a structure represented by formula (32); the weight-average molecular weight of the polymer is 350,000 to 600,000.
    Type: Grant
    Filed: January 20, 2021
    Date of Patent: June 15, 2021
    Assignee: China University of Petroleum (Beijing)
    Inventors: Yinbo He, Guancheng Jiang, Tengfei Dong, Lili Yang, Wuquan Li, Haiyang Liu, Xiaoqing Li, Xuwu Luo, Li Zhao, Xianbin Huang, Jingping Liu, Jingen Deng
  • Patent number: 11012409
    Abstract: There is disclosed in one example a computing apparatus, including: a hardware platform; a network interface to communicatively couple to a bus lacking native support for authentication; and an anomaly detection engine to operate on the hardware platform and configured to: receive a first data stream across a first time; symbolize and approximate the first data stream, including computing a first window sum; receive a second data stream across a second time substantially equal in length to the first time, the second data stream including data across the plurality of dimensions from the first data stream; symbolize and approximate the second data stream, including computing a second window sum; compute a difference between the first window sum and the second window sum; determine that difference exceeds a threshold and that the correlation across the plurality of dimensions is broken; and flag a potential anomaly.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: May 18, 2021
    Assignee: Intel Corporation
    Inventors: Liuyang Lily Yang, Huaxin Li, Li Zhao, Marcio Juliato, Shabbir Ahmed, Manoj R. Sastry
  • Publication number: 20210122851
    Abstract: The present disclosure relates to the field of drilling fluid, and particularly relates to an ionic liquid shale inhibitor for drilling fluid, and a preparation method and an application thereof. The method comprises the following steps: subjecting the imidazole-based ionic liquid to a polymerization reaction in water environment under an inert atmosphere, the produced polymer is used as an ionic liquid shale inhibitor for drilling fluid. The ionic liquid shale inhibitor for drilling fluid has the advantages of desirable inhibition effect, good compatibility, strong high-temperature resistance, simple preparation method and low cost.
    Type: Application
    Filed: October 29, 2020
    Publication date: April 29, 2021
    Inventors: Lili YANG, Guancheng JIANG, Xiao YANG, Tengda WANG, Yawei SHI
  • Publication number: 20210124835
    Abstract: Systems and methods generate a first security node hash identifier by performing a first hash operation, such as a one-way hash, on a first data resource identifier associated with a first data resource, such as a data set, produced by a data resource platform. The systems and methods generate a dependent second security node hash identifier by performing a second hash operation on a second data resource identifier associated with a dependent second data resource produced by the data resource platform and on the first security node hash identifier, receive an access request for access to the dependent second data resource; and in response to the access request, grant permission to access the dependent second data resource to a user associated with the access request based on the dependent second security node hash identifier.
    Type: Application
    Filed: January 3, 2020
    Publication date: April 29, 2021
    Inventors: Lam Tran, James Baker, Lili Yang
  • Publication number: 20210123022
    Abstract: Embodiments of the disclosure include compositions and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. In particular embodiments, the iNKT cells are produced from hematopoietic stem progenitor cells and also are suitable for allogeneic cellular therapy because they are HLA negative. In specific embodiments, the cells are cultured in a particular in vitro three-dimensional artificial thymic organoid system and the cells have imaging and suicide targeting capabilities.
    Type: Application
    Filed: June 12, 2019
    Publication date: April 29, 2021
    Applicant: The Regents of the University of California
    Inventors: Lili Yang, Yanni Zhu, Christopher Seet, Amelie Montel Hagen, Gay Crooks
  • Publication number: 20210112065
    Abstract: A system and method for authenticating users of a data processing platform stores a mapping of a unique user platform identifier to multiple user identity provider identifiers associated with multiple realms for a same user. In some examples, the method includes receiving a request from a client device to establish an access session to perform one or more actions on data of the data processing platform and receiving, from at least one of the first external identity provider of the first realm or the second external identity provider of the second realm, a user identity provider identifier associated with the request. In certain examples, the method includes granting permission to perform the one or more actions on the data of the data processing platform based at least in part on the received user identity provider identifier.
    Type: Application
    Filed: October 24, 2019
    Publication date: April 15, 2021
    Inventors: Lili Yang, Mark Elliot, Lam Tran, Robert Kruszewski, Divyanshu Arora
  • Publication number: 20210077637
    Abstract: The present disclosure provides a pH and oxygen dual-sensitive magnetic resonance imaging contrast agent and a preparation method thereof, which is a dual-modal nanoparticle contrast agent with 19F signal and CEST dual signal (19F-CEST), a CEST contrast agent that is dual-sensitive to pH and oxygen. The preparation method comprises: mixing a variety of phospholipid surfactants and cholesterol well to obtain a blend of phospholipid surfactants, which is dissolved in chloroform or a mixed solvent of chloroform and methanol, evaporated to dryness with a rotary evaporator and dried overnight in a vacuum oven at 40° C. after adding rhodamine, finally, it is dispersed in water containing glycerin by mechanical dispersion or ultrasonic vibration to obtain a lipid modifier; mixing perfluorocarbon, the lipid modifier obtained in step (1), glycerin, and water and ultrasonically mixing well with a probe, and extruding with an extruder to prepare a perfluorocarbon nanoemulsion.
    Type: Application
    Filed: September 30, 2020
    Publication date: March 18, 2021
    Inventors: Xinlin Sun, Lina Wu, Rong A, OLAGBAJU OLUWATOSIN ATINUKE, Kai Wang, Lili Yang, Lixin Cheng, Wenju Qiao, Xiaohong Sun
  • Patent number: 10927160
    Abstract: Disclosed are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof. Specifically, the engineered cells iNKT are genetically modified to contain at least one exogenous invariant natural killer T cell receptor (iNKT TCR) nucleic acid molecule. Further disclosed are iNKT TCR nucleotide sequences and codon optimized sequences for expression.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: February 23, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Lili Yang, Drake J. Smith
  • Publication number: 20210015439
    Abstract: Disclosed is a molecular imaging method for evaluating liver regeneration ability after ALPPS. The method includes steps of: 1) preparing a VX2 rabbit liver cancer model; 2) performing ALPPS for the VX2 rabbit liver cancer model; 3) synthesizing 18F-Fluoromethylcholine (18F-Methylcholine, 18F-FCH); 4) PET/CT imaging and data processing for 18F-FCH. The disclosure is the first to propose the use of 18F-FCH PET/CT to monitor the proliferative capacity of residual liver, and further indirectly reflect the increased ability of cell membrane synthesis on the basis that 18F-FCH has higher choline metabolism in residual liver tissue, so that the liver regeneration ability after ALPPS is evaluated by the molecular imaging method, thereby providing important new ideas for the clinical selection of ALPPS to choose the best time for second-stage surgery.
    Type: Application
    Filed: September 30, 2020
    Publication date: January 21, 2021
    Inventors: xinlin Sun, zhen Quan, Ruifeng Wang, kai Wang, lili Yang, zunyu Xiao, yang Liu, zhaoguo Han, xiang Liu, mingxing Ke
  • Patent number: 10889742
    Abstract: The present disclosure relates to the technical field of water-based drilling fluid, in particular to a modified polyhistidine suitable for being used as a supramolecular shale inhibitor, a method of preparing the same, and its application in water-based drilling fluids. The modified polyhistidine has a histidine polymerization main chain comprising a structural unit, which is represented by Formula (1) and attached with a modifying group, and the histidine polymerization main chain has a histidine polymerization degree of 6-9. The modified polyhistidine provided by the present disclosure is a degradable biological material and has the advantage of environmental friendliness; when the modified polyhistidine is used as a shale inhibitor, it can take advantage of its supermolecular property to effectively inhibit the hydration expansion of montmorillonite which is the most important expansion mineral in shale, and exhibits excellent inhibition effect and desirable temperature resistance.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: January 12, 2021
    Assignees: CHINA UNIVERSITY OF PETROLEUM (BEIJING), BEIJING SHIDA BOCHENG TECHNOLOGY CO., LTD
    Inventors: Guancheng Jiang, Yinbo He, Lili Yang, Kai Wang, Tengfei Dong, Xiaohu Quan, Kaixiao Cui, He Shi
  • Patent number: 10876034
    Abstract: The present disclosure relates to the technical field of oil and gas drilling, and particularly relates to a modified silicon dioxide material of a fluorocarbon active agent type super-amphiphobic cutting-carrying agent suitable for a water-based drilling fluid, and a preparation method thereof. The preparation method of the modified silicon dioxide material comprises the following steps: subjecting silicon dioxide and a silane coupling agent represented by Formula (1) to a first contact reaction in a mixed solvent containing alcohol and water; subjecting the product of the first contact reaction, the compound represented by Formula (2) and the compound represented by Formula (3) to a second contact reaction; subjecting the product of the second contact reaction and the compound represented by Formula (4) to a third contact reaction. The modified silicon dioxide material can be used as a cutting-carrying agent in a water-based drilling fluid and produce an excellent cutting-carrying effect.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: December 29, 2020
    Assignee: CHINA UNIVERSITY OF PETROLEUM (BEIJING)
    Inventors: Guancheng Jiang, Xiaoxiao Ni, Yinbo He, Lili Yang, Tengfei Dong, Kun Zhang, Xuwu Luo, Li Zhao, Yang Bai, Kaihe Lv, Xianbin Huang, Jingping Liu, Chunyao Peng
  • Publication number: 20200261604
    Abstract: The present invention provides a 19F-MR/fluorescence multi-mode molecular imaging and drug loading diagnosis-treatment integrated nanoprobe, and a preparation method and an application. The nano-probe is a nanoparticle formed by coating a mixture of a surfactant containing a molecular targeting treatment drug and a fluorescent dye with a Perfluorocarbon (PFC) carrier; and by uniformly dispersing a mixed solution into water and glycerol, processing ultrasonically, removing a component which is not effectively coated, and purifying, the drug-loading nanoparticle capable of being used for 19 F-MR imaging may be prepared.
    Type: Application
    Filed: April 23, 2020
    Publication date: August 20, 2020
    Inventors: Xilin SUN, Lina WU, Jie YANG, Kai WANG, Lili YANG, Haoxiang LI, Yingbo LI, Xiaona LI, Shuang LIU
  • Publication number: 20200253883
    Abstract: This disclosure relates to nanoparticles coated with fusion proteins comprising a domain that binds a cancer marker and a domain comprising a toxic polypeptide. In certain embodiments, the targeted cancer marker is urokinase plasminogen activator receptor (uPAR) insulin-like growth factor 1 receptor (IGF1R), EGFR, HER2, and/or other member of the ErbB family of receptors. In certain embodiments, the molecule that binds a cancer marker is an amino terminal fragment of uPA or variant capable of binding uPAR and/or IGF1 or variant capable of binding IGF1R. In certain embodiments, the toxic polypeptide is a bacterial exotoxin.
    Type: Application
    Filed: September 27, 2018
    Publication date: August 13, 2020
    Inventors: Lily Yang, Xiangxue Guo, Hui Mao, Wei Chen