Abstract: This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the nanoparticle and wherein a catalytic domain of a protease is linked to the nanoparticle. In certain embodiments, the targeting molecule and the catalytic domain are within a single polypeptide sequence. In certain embodiments, the targeting molecule binds a molecule more highly expressed on cancer cells then non-cancerous cells, and the nanoparticles disclosed herein are used for the treatment of cancer by further attaching an anti-cancer agent to the nanoparticle or incorporating an anticancer agent within the nanoparticle.

Abstract: The present invention relates to the field of petroleum industry phase oilfield chemistry, and specifically relates to a bionic and dual-phobic drilling fluid. The drilling fluid contains a bionic wall-fixing agent, a bionic lubricant, a super dual-phobic agent, a scrap-carrying agent and a bionic shale inhibitor. The present invention uses the theory of bionics and the theory of a downhole rock surface being double phobic as a basis. By means of using the bionic wall-fixing agent, the bionic lubricant, the super dual-phobic agent, the scrap-carrying agent and the bionic shale inhibitor, which have special properties of imitating animals and plants in nature, and using a series of bionic treatment agents, a set of bionic and dual-phobic drilling fluid systems, which corresponds to an unconventional, complex oil and gas well, is formed.

Abstract: This disclosure relates to nanoparticles coated with fusion proteins comprising a domain that binds a cancer marker and a domain comprising a toxic polypeptide. In certain embodiments, the targeted cancer marker is urokinase plasminogen activator receptor (uPAR) insulin-like growth factor 1 receptor (IGF1R), EGFR, HER2, and/or other member of the ErbB family of receptors. In certain embodiments, the molecule that binds a cancer marker is an amino terminal fragment of uPA or variant capable of binding uPAR and/or IGF1 or variant capable of binding IGF1R. In certain embodiments, the toxic polypeptide is a bacterial exotoxin.

Abstract: This disclosure relates to palladium hyaluronic acid particles such as dibenzylideneacetone palladium hyaluronic acid particles. In certain embodiments, this disclosure relates to methods of managing cancer or angiogenic conditions using particles disclosed herein and pharmaceutical compositions comprising the same. In certain embodiments, an objective of this disclosure is hyaluronic acid targeting of CD44, a tumor stem cell marker. In certain embodiments, this disclosure relates to treatment with hyaluronic acid palladium particles disclosed herein for depleting CD44 cells.

Abstract: An apparatus and system to mitigate non-genuine handovers are described. The handovers include handovers based on fake measurements and handovers to malicious cells. To mitigate these, a mitigation procedure is initiated when excessive handovers are detected. Location information obtained from the UE, estimation of PHY layer properties by the serving and/or target cell, or AI modeling of the best serving cell at the UE location is used to determine whether the handover is valid. If not, the handover is canceled and the UE is stopped from initiating new handovers for a specified time, the UE may be instructed to perform re-authentication with the network, and/or the serving cell recommends to the network authentication entity to revoke the UE authentication. To ensure that the target cell is legitimate, an AI model is used to classify the target cell as known/unknown and the result sent to the network in NAS signaling.

Abstract: A computing node includes interface circuitry and processing circuitry. To implement a spectrum harvesting entity in a wireless network configured for crowdsource-based unlicensed spectrum harvesting, the processing circuitry is configured to select a set of crowdsourcing nodes from a plurality of crowdsourcing nodes available in the wireless network. A plurality of spectrum occupancy reports (SORs) is received from the set of crowdsourcing. Each of the plurality of SORs indicates a channel occupancy status of a communication channel in the unlicensed spectrum sensed by a corresponding crowdsourcing node of the set and geolocation associated with the corresponding crowdsourcing node. A spectrum occupancy map of the unlicensed spectrum is generated based on the channel occupancy status and the geolocation provided in the plurality of SORs by each crowdsourcing node of the set of crowdsourcing nodes.

Abstract: The invention relates to the technical field of oil and gas drilling, and discloses an amphiphilic block polymer ultralow-permeability agent and an intelligent temporary plugging type water-based drilling fluid. The ultralow-permeability agent contains a structural unit provided by styryl hydrophobic monomer, maleic anhydride and acrylamide; the drilling fluid contains two or more of water, sodium bentonite, Pac-Lv, the ultralow-permeability agent, calcium carbonate, one-way plugging agent, white asphalt and barite which are stored in a mixed manner or independently stored.

Abstract: The invention relates to the technical field of oilfield exploration, and discloses a 4D quantitative and intelligent diagnosis method and system for spatio-temporal evolution of oil-gas reservoir damage types and extent. The method includes: determining a characteristic parameter characterizing reservoir damage by each of a plurality of factors based on a spatio-temporal evolution simulation equation of reservoir damage by each of the plurality of factors; and determining an effective characteristic parameter characterizing the damage extent of the reservoir based on the characteristic parameter characterizing reservoir damage rby each of the plurality of factors. The invention can quantitatively simulate the characteristic parameters of reservoir damage caused by the various factors and a total characteristic parameter of the reservoir damage.

Abstract: System and techniques for an environmental control loop are described herein. A device for an environmental control loop can include a memory including instructions and processing circuitry that when in operation, can be configured by the instructions to receive environmental sensor data from a first component in a set of heterogeneous components installed in an environment with a controller. The environmental sensor data can indicate a service level value sensed by the first component. The controller can also measure a violation of a service level objective based on comparing the environmental sensor data to a threshold. The controller can also transmit an adjustment to an operating parameter of a second component of the set of heterogeneous components. The adjustment can be operative to attenuate the violation of the service level objective when implemented by the second component.

Abstract: A first roadway system receives a communication from a second roadway system over a wireless channel, where the communication includes a description of a physical object within a driving environment. Characteristics of the physical object are determined based on sensors of the first roadway system. The communication is determined to contain an anomaly based on a comparison of the description of the physical object with the characteristics determined based on the sensors of the first roadway system. Misbehavior data is generated to describe the anomaly. A remedial action is initiated based on the anomaly.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed that provide an apparatus to analyze vehicle perspectives, the apparatus comprising a profile generator to generate a first profile of an environment based on a profile template and first data generated by a first vehicle; a data analyzer to: determine a difference between the first profile and a second profile obtained from a first one of one or more nodes in the environment; and in response to a trigger event, update the first profile based on the difference; and a vehicle control system to: in response to the trigger event, update a first perspective of the environment based on one or more of second data from the first one of the one or more nodes or the updated first profile; update a path plan for the first vehicle based on the updated first perspective; and execute the updated path plan.

Abstract: Disclosed herein are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof.

Abstract: The invention relates to a method for forming flip chip bumps using electroplating. The method allows the formation of flip chip bumps in a way that is compatible with already-formed sensitive electronic components, such as Josephson junctions, which may be used in quantum processing units. The invention also relates to a product and a flip chip package in which flip chip bumps are formed with the disclosed method.

Abstract: Superconducting through substrate vias (STSVs) are disclosed. The STSVs provide superconducting interconnections between opposite faces of a substrate. In an example, a method of forming STSVs includes etching openings that extend from a first side of a substrate partially through the substrate towards a second side of the substrate. The method also includes depositing a seed layer over the first side of the substrate and interior surfaces of the openings in the substrate. The method further includes forming a resist or hardmask on the first side of the substrate above the seed layer, such that the resist or hardmask comprises openings aligned with the etched openings in the substrate. The etched openings in the substrate are filled with a superconducting filler material. The substrate is thinned by removing material from the second side of the substrate until the deposited seed layer is exposed on the second side of the substrate.

Abstract: Systems and techniques for securing vehicle privacy in a driving infrastructure are described herein. A vehicle may contact a group identification (ID) issuer to register itself. A group ID may be received from the group ID issuer to indicate acceptance as a member. The vehicle may then contact the driving infrastructure to attach to the driving infrastructure using the group ID to identify the vehicle. In response, the vehicle receives an attachment ID from the driving infrastructure. Here, the attachment ID is used to secure communications between the vehicle and the driving infrastructure.

Abstract: The invention relates to the field of drilling fluid, in particular to a saturated salt water drilling fluid of salt response type intelligent polymer and preparation method thereof. The drilling fluid contains two or more of the following components stored in admixture or separately: bentonite, NaOH, KCl, calcium carbonate, barite, NaCl, supramolecular fluid loss additive, supramolecular shear-enhancing agent, plugging agent, coating agent and water. The drilling fluid provided by the invention has the characteristics of salt response and self-assembly, can keep rheological properties such as rapid recovery of the sheared structure, low extreme high shear rate viscosity, good shear dilution property and the like in a high-salt environment, has good fluid loss reduction performance, reservoir protection performance and debris dispersion inhibition performance, and has good temperature resistance and pollution resistance performance.

Abstract: The invention relates to the field of oilfield chemistry, and discloses a self-repairing plugging gel polymer for drilling fluid, a preparation method and application thereof, and the drilling fluid containing the gel polymer, wherein the polymer contains a structural unit A, a structural unit B, a structural unit C and a structural unit D, and the structural unit A is a structural unit with a structure shown in the formula (1); the structural unit B is a structural unit with a structure shown in the formula (2); the structural unit C is a structural unit with a structure shown in the formula (3); the structural unit D is a structural unit having a structure represented by the formula (4).

Abstract: As disclosed herein, we have discovered that creatine is a critical molecule buffering ATP levels in cancer-targeting CD8 T cells through maintaining a readily available high-energy phosphate reservoir. Building upon this discovery, we have designed a number of methods for modulating energy metabolism in a population of tumor-infiltrating CD8 T cells, methods that can be adapted for use in therapeutic regimens for the treatment of cancer. Illustrative embodiments of the invention include methods for enhancing tumor-infiltrating CD8 T cells ability to mount and sustain a response to tumor cells comprising increasing the concentrations of creatine available for tumor-infiltrating CD8 T cells energy metabolism, thereby enhancing the ability of the tumor-infiltrating CD8 T cells to mount and sustain a response to the tumor cells.

Abstract: A vehicle control system, including an in-vehicle bus and a plurality of electronic control units (ECUs) coupled to the in-vehicle bus, wherein at least one ECU of the plurality of ECUs is configured to: receive, at a respective at least one ECU of the plurality of ECUs, a message in a message stream on the in-vehicle bus; evaluate the message to determine at least one of a confidence value of the security classification, a significance value of the message, or a bounds check value of the message; and determine in real-time to allow or deny the message to the vehicle control system based on at least one of the significance value of the message, the bounds check value of the message, or the confidence value of the security classification of the message, to provide a sanitized message stream to the vehicle control system.

Abstract: Aspects of the present disclosure relate to methods and compositions related to the preparation of immune cells, including engineered immune cells. Certain embodiments of the disclosure include compositions, cells, and methods related to engineered invariant natural killer T (iNKT) cells for off-the-shelf use for clinical therapy. The iNKT cells may be produced from hematopoietic stem progenitor cells and may be suitable for allogeneic cellular therapy because they are HLA negative. In some aspects, the cells have imaging and suicide targeting capabilities.