Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

Abstract: A patrol and inspection vehicle includes a vehicle body, distance measuring devices installed on front and rear sides of the vehicle body for detecting distances of ambient objects, a LiDAR sensor installed on the vehicle body for constructing a three-dimensional spatial model for positioning and navigation, a panoramic camera installed on the vehicle body for recognizing images of ambient individuals, and a gas detector installed on the vehicle body for detecting leaked gases having a temperature different from room temperature. The patrol and inspection vehicle can automatically inspect whether there are gas leaks in pipelines and detect if individuals have accidentally entered restricted areas, thereby reducing the manpower required for patrols and enhancing factory safety.

Abstract: Provided are a silicon-based display assembly and a display device. The silicon-based display assembly is provided with a silicon-based panel, a flexible circuit board, and a logic control board. An end of the flexible circuit board is bonded to a first bonding region of the silicon-based panel. The logic control board is disposed on the flexible circuit board. The logic control board is integrated with a timing controller module, an algorithm processing module, a first input interface module, a first output interface module, and a power module. The logic control board is configured to at least perform high-speed data receiving and high-speed data processing.

Abstract: Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

Abstract: Provided are compositions comprising acid alpha glucosidase (GAA) having increased phosphorylation of High Mannose N-linked Oligosaccharides. Also provided herein are methods of treating Pompe disease comprising administering to a subject the compositions of the disclosure.

Abstract: Provided are compositions comprising vectors for the co-expression of a modified GlcNAc-1-Phosphotransferase gene and a lysosomal enzyme. The gene encoding the lysosomal enzyme is operably linked to a first promoter and the gene encoding the GlcNAc-1-Phosphotransferase is operably linked to a second promoter. Also provided herein are methods of treating a lysosomal storage disorder comprising administering to a subject the compositions of the disclosure.

Abstract: A flow guiding device in an immersion-cooled chassis of a server comprises at least one deflector located above a chip on a mainboard in the chassis, each deflector comprises a first end for mounting to the mainboard above the chip and a second end inclined away from the mainboard. The first end is immersed in coolant, the second end is higher than the first end; the deflector further comprises a hollow part including multiple through holes for interrupting upward movement vapor bubbles generated by the hot chip, which reduces probability of the vapor bubbles escaping from the coolant liquid and the chassis. A liquid-cooled chassis having the flow guiding device is also disclosed.

Abstract: This application discloses an application information display method and a related device. The method includes: An electronic device detects an update event of application information of a first application, and in response to the update event, the electronic device determines whether the first application is locked by an application lock, where the application information may be a widget or a notification message; and the electronic device displays a locking view over the application message after determining that the first application is locked by the application lock.

Abstract: A bridge device includes a first controller and a second controller. The first controller includes a first transmission interface. The second controller includes a second transmission interface. The first transmission interface and the second transmission interface are flash memory interfaces. In a program mode, the first transmission interface receives a first command from the second transmission interface and obtains first transfer data from a bus in response to the first command. A value of the first command is optionally set to a first value or a second value. The first value indicates a memory command transfer operation in a first direction and the second value indicates a memory data transfer operation in the first direction. The first transmission interface processes the first transfer data according to the value of the first command to obtain a memory command or written data.

Abstract: The disclosure provides a resin composition, a substrate, and a copper clad laminate, wherein the resin composition includes a naphthalene ring epoxy resin, a bismaleimide resin, a crosslinking agent, polysiloxane, an accelerator, and a filler.

Abstract: This invention generally relates to a novel induced cytoplasmic IVT (ICIVT) composition useful for inducing in-vitro transcription (IVT)-like RNA/mRNA amplification in the cells of interest after transfection in vitro, ex vivo and/or in vivo. The present invention is useful for designing and developing a variety of RNA/mRNA medicines as well as vaccines comprising a mixture of at least a promoter-linked RNA/mRNA-coding DNA (PLRcD) template and another DNA-dependent RNA polymerase (DdRP) mRNA sequence. Preferably, the DdRP mRNA may be selected from the mRNA of T7, T3 and/or SP6 RNA polymerase, or a combination thereof, while the PLRCD template may encode the transcripts of antisense RNA oligonucleotide (aRNA-ASO), small interferring RNA (siRNA), double-stranded RNA (dsRNA), short hairpin RNA (shRNA), microRNA (miRNA)/microRNA precursor (pre-miRNA), long noncoding RNA (lncRNA), messenger RNA (mRNA), and/or self-amplifying RNA/mRNA (saRNA/samRNA), or a combination thereof.

Abstract: A circuit includes a voltage divider circuit configured to generate a feedback voltage according to an output voltage, an operational amplifier configured to output a driving signal according to the feedback voltage and a reference voltage and a pass gate circuit including multiple current paths. The current paths are controlled by the driving signal and connected in parallel between the voltage divider circuit and a power reference node.

Abstract: An integrated circuit includes a first temperature-sensitive device having a first stacked gate device formed and a second stacked gate device, and a second temperature-sensitive device having a third stacked gate device. The first temperature-sensitive device is configured to generate a first voltage which monotonically increases with an absolute temperature. The second temperature-sensitive device is configured to generate a second voltage which monotonically decreases with the absolute temperature. The integrated circuit also includes an output terminal configured to generate a reference voltage which is based on the first voltage from the first temperature-sensitive device and the second voltage from the second temperature-sensitive device. Each of the first stacked gate device, the second stacked gate device, and the third stacked gate device is formed with a first group of field-effect transistors stacked together.

Abstract: The present disclosure provides an adapter bracket, which includes a first portion, a second portion and a third portion. The first portion includes a protruding portion extending from a first bottom surface of the first portion in a direction perpendicular to the first bottom surface. The second portion, has an elevation with respect to the first bottom surface of the first portion. The second portion comprising a first hole. The third portion extends between the first portion and the second portion.

Abstract: An electronic package and a manufacturing method thereof are provided, in which a first optoelectronic element having a first optical fiber connection portion is disposed on an electronic module, a second optoelectronic element having a second optical fiber connection portion is disposed on a first level layer of a lower carrying portion of a step-shaped carrier structure, and the electronic module is disposed on a second level layer of the step-shaped carrier structure and the second optoelectronic element having the second optical fiber connection portion, so that the electronic module is electrically connected to the second optoelectronic element having the second optical fiber connection portion. Thereby, two optoelectronic elements having optical fiber connection portions can be easily and vertically integrated, and the second optoelectronic element can be stably carried by the step-shaped carrier structure.

Abstract: An overlay mark includes a previous layer mark and a current layer mark. The previous layer mark includes a plurality of first work zones. Each first working zone includes a first sub-region and a second sub-region, wherein the first sub-region is closer to a center point of the previous layer mark than the second sub-region. The previous layer mark includes a first mark and an auxiliary mark respectively in the first sub-region and the second sub-region of each first working zone. The current layer mark includes a plurality of second working zones. Each second working zone includes a first sub-region and a second sub-region. The current layer mark includes a second mark disposed in the second sub-region of each second working zone. The overlay mark may be applied in the process of manufacturing a 3D NAND flash memory with high capacity and high performance.

Abstract: A system, device and method are provided for ingesting data onto cloud computing environments. The illustrative method includes providing an accelerator in a cloud computing environment for ingestion of data into the cloud computing environment. The method includes automatically, with the accelerator (1) verifying that one or more templates defining ingestion parameters are populated on the cloud computing environment, (2) verifying that resources in a target destination in the cloud computing environment have been provisioned, (3) populating, based on the one or more templates, and with a pipeline of tasks, one or more configuration reference destinations for transforming raw data into a format compatible with the provisioned target destination. The method includes ingesting a data file into the verified target destination in the cloud computing environment based on the verified one or more templates and populated configuration reference destinations.

Abstract: The present disclosure provides a resistive device. The resistive device includes a conductive structure, a row of first vias, and a row of second vias. The conductive structure has a first side and a second side opposite to the first side, and a first surface connected between the first side and the second side. The row of first vias extends through the conductive structure in a first direction substantially perpendicular to the first surface. The row of first vias is closer to the first side than the second side. The row of second vias extends through the conductive structure in the first direction. The row of second vias is disposed between the first side of the conductive structure and the row of first vias.

Abstract: A semiconductor device includes a bipolar junction transistor (BJT) structure including emitters in a first well having a first conductive type, collectors in respective second wells, the second wells having a second conductive type different from the first conductive type and being spaced apart from each other with the first well therebetween, and bases in the first well and between the emitters and the collectors. The BJT structure includes active regions having different widths that form the emitters, the collectors, and the bases.